Results 1 to 10 of about 80 (76)

The Role of Selenoproteins SELENOM and SELENOT in the Regulation of Apoptosis, ER Stress, and Calcium Homeostasis in the A-172 Human Glioblastoma Cell Line

Biology, 2022
It is known that seven mammalian selenoproteins are localized in the endoplasmic reticulum: SELENOM, SELENOT, SELENOF, SELENOK, SELENOS, SELENON, and DIO2.
Elena G. Varlamova, Michael V. Goltyaev, Egor A. Turovsky   +2 more
doaj   +3 more sources

Evaluation of the Cytotoxic Effects of Ciprofloxacin on Human Glioblastoma A-172 Cell Line

Middle East Journal of Cancer, 2017
Background: Glioblastoma multiforme, the most common, aggressive malignant brain tumor which affects patients of all ages, is principally resistant to treatment. Ciprofloxacin is an antibiotic that belongs to the fluoroquinolones.
Ashkan Zandi, Taraneh Moini Zanjani, Seyed Ali Ziai, Yalda Khazaei Poul, Mostafa Haji Molla Hoseini   +4 more
doaj   +1 more source

The Synergistic Effects of the Combination of Ciprofloxacin and Temozolomide on Human Glioblastoma A-172 Cell Line

Middle East Journal of Cancer, 2017
Background: Combination therapy has generated remarkable motivation in the clinical setting since it boosts the therapeutic potential of anticancer drugs.
Ashkan Zandi, Taraneh Moini Zanjani, Seyed Ali Ziai, Yalda Khazaei Poul, Mostafa Haji Molla Hoseini   +4 more
doaj   +1 more source

The Toxicity of Synthetic and Biogenic Selenium Nanoparticles on Human Brain Glioblastoma Cell Line: An in vitro Comparison [PDF]

International Journal of Medical Toxicology and Forensic Medicine, 2020
Background: Brain tumors can be serious and life-threatening when they are treated effectively. Many therapeutic approaches, such as chemotherapy, radiotherapy, and surgery have been used to treat brain tumors.
Shideh Khangholi, Mehdi Mahdavi, Mohammad Hossein Yazdi, Ahmad Reza Shahverdi   +3 more
doaj   +1 more source

Bis-Bibenzyls from the Liverwort Pellia endiviifolia and Their Biological Activity

Plants, 2021
Based on previous investigations where bis-bibenzyls isolated from liverworts showed various biological activities (cytotoxic, antimicrobial, and antiviral), we investigated their cytotoxic activity in several human cancer cell lines.
Ivana Ivković, Miroslav Novaković, Milan Veljić, Marija Mojsin, Milena Stevanović, Petar D. Marin, Danka Bukvički   +6 more
doaj   +1 more source

Mechanism of Ca²⁺-Dependent Pro-Apoptotic Action of Selenium Nanoparticles, Mediated by Activation of Cx43 Hemichannels

Biology, 2021
To date, there are practically no data on the mechanisms of the selenium nanoparticles action on calcium homeostasis, intracellular signaling in cancer cells, and on the relationship of signaling pathways activated by an increase in Ca2+ in the cytosol ...
Egor A. Turovsky, Elena G. Varlamova
doaj   +1 more source

Synthesis of silver nanoparticles using Salvia officinalis extract: Structural characterization, cytotoxicity, antileishmanial and antimicrobial activity [PDF]

Nanomedicine Research Journal, 2020
Objective: This study aimed to investigate the cytotoxicity, antileishmanial and antibacterial potential of silver nanoparticles (AgNPs) synthesized by (Salvia officinalis L. (Sage)) extract.
Fatemeh Sharifi, Fariba Sharififar, Sara Soltanian, Mohsen Doostmohammadi, Neda Mohamadi   +4 more
doaj   +1 more source

Lichen Secondary Metabolites Inhibit the Wnt/β-Catenin Pathway in Glioblastoma Cells and Improve the Anticancer Effects of Temozolomide

Cells, 2022
Lichens are a source of secondary metabolites with significant pharmacological potential. Data regarding their possible application in glioblastoma (GBM) treatment are, however, scarce.
Aleksandra Majchrzak-Celińska, Robert Kleszcz, Elżbieta Studzińska-Sroka, Agnieszka Łukaszyk, Anna Szoszkiewicz, Ewelina Stelcer, Karol Jopek, Marcin Rucinski, Judyta Cielecka-Piontek, Violetta Krajka-Kuźniak   +9 more
doaj   +1 more source

Comparative Study of the Anticancer Effects of Selenium Nanoparticles and Selenium Nanorods: Regulation of Ca²⁺ Signaling, ER Stress and Apoptosis

Applied Sciences, 2023
The anti-cancer effects of selenium sources are well known. Among other things, selenium has been shown to have a pleiotropic effect, causing cancer cell death without affecting the healthy cell’s viability, or, in the case of brain cells, has a ...
Elena G. Varlamova, Ilya V. Baimler, Sergey V. Gudkov, Egor A. Turovsky   +3 more
doaj   +1 more source

Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG

Oncology Reports, 2007
The apoptotic effects of 2-amino-4,4alpha-dihydro-4alpha, 7-dimethyl-3H-phenoxazine-3-one (Phx-1) and 2-aminophenoxazine-3-one (Phx-3) on human glioblastoma cell lines, A-172 and U-251 MG were studied. These phenoxazines extensively decreased the viability of A-172 and U-251 MG cells (IC50 of Phx-1: 60 microM, in both lines; IC50 of Phx-3: 10 and 3 ...
Ken, Shirato, Kazuhiko, Imaizumi, Akihisa, Abe, Akio, Tomoda   +3 more
openaire   +3 more sources