Results 11 to 20 of about 38,235 (163)

Conditional survival in glioblastoma: The evolution of prognostic factors over time. [PDF]

Int J Cancer
What's New? Neurooncologists rely on glioblastoma risk stratification systems for incorporating known disease‐ and patient‐specific factors at diagnosis. Although useful for general comparison and disease monitoring, these estimates are less informative for patients who survive beyond various time intervals post‐diagnosis.
Mueller T, Vasella F, Velz J, Voglis S, Akeret K, Padevit L, Schubert M, Weller J, Brüningk S, Rushing E, Sarnthein J, Gramatzki D, Häni L, Raabe A, Zeitlberger AM, Bozinov O, Le Rhun E, Weller M, Regli L, Neidert MC.   +19 more
europepmc   +2 more sources

A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes [PDF]

, 2013
Yeast cells can be killed upon expression of pro-apoptotic mammalian proteins. We have established a functional yeast survival screen that was used to isolate novel human anti-apoptotic genes overexpressed in treatment-resistant tumors.
Agaimy, Abbas, Baumgarten, Peter, Böhm, Stefanie, Diederichs, Sven, Eißmann, Moritz, Gutschner, Tony, Herpel, Esther, Kögel, Donat, Köhl, Ulrike, Melzer, Inga Maria, Mittelbronn, Michel Guy André, Moser, Julia, Rakel, Stefanie, Rieker, Ralf Joachim, Schwamb, Bettina, Siele, Dagmar, Wachter, David Lukas, Zörnig, Martin   +17 more
core   +8 more sources

Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]

, 2014
The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher, Munje, Chinmay, Shervington, Amal A, Shervington, Leroy Alexander   +3 more
core   +3 more sources

Isocitrate Dehydrogenase-Mutant Astrocytomas: Risk Stratification and Therapeutic Advance. [PDF]

MedComm (2020)
This graphical abstract synthesizes the core logic of our revised review by linking integrated diagnosis, risk stratification, and trajectory‐based management in IDH‐mutant astrocytomas across CNS WHO Grades 2–4. It highlights lineage‐defining molecular classification (IDH mutation with core co‐alterations), integrated histomolecular grading, and key ...
Wei S, Xu X, Bao J, Pan Z.
europepmc   +2 more sources

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses [PDF]

, 2020
The signalling pathways initiated by members of the transforming growth factor-β (TGFβ) family of cytokines control many metazoan cellular processes, including proliferation and differentiation, epithelial-mesenchymal transition (EMT) and apoptosis. TGFβ
A Rojas-Fernandez, A Woods, AR Ramjaun, AY Hsing, B Bierie, B Ozdamar, B-C Kim, BR Binder, C Allan, CJ David, CS Hill, DB Shackelford, EC Connolly, FA Ran, G Avery-Cooper, G Rena, G Rosti, GD Cuny, GJ Inman, GJ Inman, GM Keating, H Ikushima, J Massagué, J Massagué, J Massaous, J Ozanne, J Song, J Vogt, J Xu, JF Callahan, JL Wrana, JM Lizcano, Joan Massagué, JY Altarejos, K Clark, KA Brown, KJ Livak, LC Spender, LC Spender, M Abe, M Kowanetz, M Tojo, MO Li, MR Keeton, NJ Bright, P Lönn, PH Lin, PK Datta, PM Siegel, RJ Akhurst, RJ Akhurst, S DaCosta Byfield, S Dennler, S Edlund, S Strickson, SA Hawley, T Sonntag, TB Sundberg, Y Drabsch, Y Liu, Y Shi, Y Yang, Y Zhang, Y Zhang   +63 more
core   +2 more sources

Mir-34a-5p Mediates Cross-Talk between M2 Muscarinic Receptors and Notch-1/EGFR Pathways in U87MG Glioblastoma Cells: Implication in Cell Proliferation [PDF]

, 2018
Glioblastoma (GBM) is the most aggressive human brain tumor. The high growth potential and decreased susceptibility to apoptosis of the glioma cells is mainly dependent on genetic amplifications or mutations of oncogenic or pro-apoptotic genes ...
Bevilacqua, Valeria, Caffarelli, Elisa, De Jaco, Antonella, Di Bari, Maria, Laneve, Pietro, Piovesana, Roberta, Talora, Claudio, Tata, Ada Maria, Trobiani, Laura   +8 more
core   +2 more sources

Lactoferrin's anti-cancer properties. Safety, selectivity, and wide range of action [PDF]

, 2020
Despite recent advances in cancer therapy, current treatments, including radiotherapy, chemotherapy, and immunotherapy, although beneficial, present attendant side effects and long-term sequelae, usually more or less affecting quality of life of the ...
Bonaccorsi di Patti, M. C., Cutone, A., Ianiro, G., Lepanto, M. S., Musci, G., Rosa, L., Valenti, P.   +6 more
core   +1 more source

The role of the Bmi1-GSK3β pathway in glioblastoma [PDF]

, 2010
Malignant gliomas remain one of the deadliest of all cancers despite maximal therapy. They present unique challenges to therapy with a median survival of 12 months.
Korur, Serdar
core   +1 more source

Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG

Oncology Reports, 2007
The apoptotic effects of 2-amino-4,4alpha-dihydro-4alpha, 7-dimethyl-3H-phenoxazine-3-one (Phx-1) and 2-aminophenoxazine-3-one (Phx-3) on human glioblastoma cell lines, A-172 and U-251 MG were studied. These phenoxazines extensively decreased the viability of A-172 and U-251 MG cells (IC50 of Phx-1: 60 microM, in both lines; IC50 of Phx-3: 10 and 3 ...
Ken, Shirato, Kazuhiko, Imaizumi, Akihisa, Abe, Akio, Tomoda   +3 more
openaire   +3 more sources

Comparison Between Folic Acid and gH625 Peptide-Based Functionalization of Fe3O4 Magnetic Nanoparticles for Enhanced Cell Internalization

Nanoscale Research Letters, 2018
A versatile synthetic route based on magnetic Fe3O4 nanoparticle (MNP) prefunctionalization with a phosphonic acid monolayer has been used to covalently bind the gH625 peptide on the nanoparticle surface.
C. Tudisco, M. T. Cambria, A. E. Giuffrida, F. Sinatra, C. D. Anfuso, G. Lupo, N. Caporarello, A. Falanga, S. Galdiero, V. Oliveri, C. Satriano, G. G. Condorelli   +11 more
doaj   +1 more source