Results 41 to 50 of about 115,602,437 (109)

EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice [PDF]

, 2005
Background: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer. With the available treatments, survival does not exceed 12–14 mo from the time of diagnosis.
Levitzki, Alexander, Alexander Levitzki (32255), Shir Alexei, Levitzki Alexander, Manfred Ogris, Ernst Wagner (60760), Wagner, Ernst, Ernst Wagner, Ogris Manfred, Alexander Levitzki, Ogris, Manfred, Manfred Ogris (60759), Alexei Shir (60758), Shir, Alexei, Wagner Ernst, Alexei Shir   +15 more
core   +2 more sources

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells [PDF]

, 2013
Background: The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence.
Mittelbronn, Michel Guy André, Janina Seznec, Michel Mittelbronn, Jürgen Schlegel, Surowiak, Pawel, Ulrike Naumann, Klaus Mantwill, Naumann, Ulrike, Vroni Girbinger, Per Holm, Dagmar Beier, Girbinger, Vroni, Lage, Hermann, Holm, Per Sonne, Pawel Surowiak, Hermann Lage, Schlegel, Jürgen, Beier, Dagmar, Seznec, Janina, Mantwill, Klaus   +19 more
core   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant‐derived active ingredients

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat, Yasin Turanlı, Nihat Kurt, Sefa Gözcü, Emre Tunçel, Hilal Bacanak, Eren Aytekin, Sedat Ünal   +7 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Current Trends and Future Prospects of Integrating Electrospinning With 3D Printing Techniques for Mimicking Bone Extracellular Matrix Scaffolds

Journal of Polymer Science, Volume 63, Issue 6, Page 1481-1504, 15 March 2025.
ABSTRACT This article presents a review of the recent findings on the combination of electrospun nanofibers and three‐dimensional (3D)‐printed structures for extracellular matrix (ECM) scaffolds for bone tissue engineering. We explore the synergy between electrospinning (ES), which produces highly porous, fibrous structures from materials like collagen
Kardo Khalid Abdullah, Kolos Molnár
wiley   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

Small‐Scale Magnetic Soft Robots for Medical Applications: From Laboratory to Clinical Use

SmartBot, EarlyView.
Small‐scale magnetic soft robots are emerging as promising platforms for minimally invasive diagnosis and therapy in complex in vivo environments. This review compares untethered and tethered medical magnetic robots in parallel across five translational stages, from basic performance testing to clinical evaluation.
Xingxing Ke, Shizhi Li, Tianrui Zhang, Yue Zhong, Songyang Li, Shuo Zhang, Zhiping Chai, Menghao Pu, Zisheng Zong, Haochen Yong, Xingxing Dong, Lanting Huang, Zhen Deng, Shuaizheng Yan, Yue Zhang, Zhaoju Zhu, Mingzhu Zhu, Linze Li, Ruiquan Chen, Shu Zhang, Chong Wu, Di Wu, Lei Yang, Rui Chen, Tongzhi Niu, Hongling Qin, Han Ding, Bingwei He, Siqi Wu, Zhigang Wu   +29 more
wiley   +1 more source