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Temozolomide in aggressive pituitary adenomas and carcinomas
Clinics, 2012 Temozolomide is an alkylating agent used in the treatment of gliomas and, more recently, aggressive pituitary adenomas and carcinomas. Temozolomide methylates DNA and, thereby, has antitumor effects.
Leon D. Ortiz +7 more
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Neoplasia: An International Journal for Oncology Research, 2008 Purpose: The aims of the present work were to investigate the in vitro and in vivo antiangiogenic effects of chronic temozolomide treatment on various glioma models and to demonstrate whether bevacizumab (Avastin) increased the therapeutic benefits ...
Véronique Mathieu +7 more
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Should CD4 Levels be Monitored in a Patient on Temozolomide? [PDF]
European Journal of Case Reports in Internal Medicine, 2021 Introduction: Temozolomide is an alkylating agent, indicated in the treatment of refractory anaplastic astrocytoma and newly diagnosed glioblastoma. We describe a case of Salmonella typhimurium bacteraemia associated with septic arthritis in the setting ...
Sriram Gonakoti, Luis Parra-Rodriguez
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An Unusual Case of Aplastic Anemia Caused by Temozolomide [PDF]
Case Reports in Medicine, 2010 Radiotherapy and concomitant/adjuvant therapy with temozolomide are a common treatment regimen for children and adults with high-grade glioma. Although temozolomide is generally safe, it can rarely cause life-threatening complications.
Gazi Comez +5 more
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Antidepressant-like effects of cannabidiol when combined with temozolomide in adult rats [PDF]
Frontiers in PharmacologyThere is a need for characterizing more efficacious therapeutic strategies for glioblastoma multiforme to overcome treatment resistance to the standardized use of temozolomide as well as to better treat its debilitating comorbidities like depression.
Laura Gálvez-Melero +8 more
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Identification and verification of the temozolomide resistance feature gene DACH1 in gliomas
Frontiers in Oncology, 2023 IntroductionThe most important chemotherapy treatment for glioma patients is temozolomide. However, the development of drug resistance severely restricts the use of temozolomide.
Qiang Gu +7 more
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Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the inhibitory effect and mechanism of temozolomide on migration and invasion of U251 human glioma cells enhanced by plumbagin.
CAI Wei +5 more
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Thermodynamic properties of temozolomide in crystalline and gaseous aggregate states
Журнал Белорусского государственного университета: Химия, 2022 Temozolomide (4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4,3,0]nona-2,7,9-triene-9-carboxamide) is an active component of antitumor immunosuppressive alkylating drugs, and it used largely for the treatment of various types of malignant tumors, including ...
Yana N. Yurkshtovich, Andrey V. Blokhin
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Application progress of temozolomide in clinical tumor chemotherapy
Chinese Journal of Contemporary Neurology and Neurosurgery, 2013 Temozolomide is an imidazotetrazine derivative of the alkylating agent, which is used to treat central nervous system tumors, especially malignant brain gliomas. It is a milestone in brain giloma chemotherapy. Recently, some researchers used temozolomide
Cheng ZHONG, Bin WANG, Sheng-qing LV
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BMC Chemistry, 2023 In this article for the first time the quantum calculations of 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide (Temozolomide) in HCM-Cellulose Substrate are evaluated using the B3LYP/6-31G level of theory.
Masoumeh Shahi, Fatemeh Azarakhshi
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