Results 21 to 30 of about 70,369 (254)

Phase I, open-label, multicentre study of buparlisib in combination with temozolomide or with concomitant radiation therapy and temozolomide in patients with newly diagnosed glioblastoma

ESMO Open, 2020
Background Most glioblastoma tumours exhibit intrinsic phosphatidylinositol 3-kinase (PI3K) pathway activation. Preclinical in vitro and in vivo models suggest that buparlisib (an oral pan-PI3K inhibitor) can have an effect on glioblastoma directly and ...
David Mills, Patrick Yung Wen, Jordi A Rodon, Warren Mason, Joseph T Beck, John DeGroot, Valerie Donnet, Mona El-Hashimy, Mark Rosenthal   +8 more
doaj   +1 more source

Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway

Frontiers in Cell and Developmental Biology, 2022
Introduction: Glioblastoma (GBM) is invariably resistant to temozolomide (TMZ) chemotherapy. Inhibiting the proteasomal pathway is an emerging strategy to accumulate damaged proteins and inhibit their lysosomal degradation.
Mohummad Aminur Rahman, Mohummad Aminur Rahman, Agnete S. T. Engelsen, Agnete S. T. Engelsen, Shahin Sarowar, Christian Bindesbøll, Even Birkeland, Dorota Goplen, Maria L. Lotsberg, Maria L. Lotsberg, Stian Knappskog, Stian Knappskog, Anne Simonsen, Anne Simonsen, Anne Simonsen, Martha Chekenya   +15 more
doaj   +1 more source

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells [PDF]

, 2013
Background: The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence.
Mittelbronn, Michel Guy André, Janina Seznec, Michel Mittelbronn, Jürgen Schlegel, Surowiak, Pawel, Ulrike Naumann, Klaus Mantwill, Naumann, Ulrike, Vroni Girbinger, Per Holm, Dagmar Beier, Girbinger, Vroni, Lage, Hermann, Holm, Per Sonne, Pawel Surowiak, Hermann Lage, Schlegel, Jürgen, Beier, Dagmar, Seznec, Janina, Mantwill, Klaus   +19 more
core   +1 more source

Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report

Journal of Medical Case Reports, 2010
Introduction We report the development of acute lymphoblastic leukemia in a patient in whom temozolomide was used for the treatment of a brain tumor. Unlike that of other alkylating agents, the leukemogenic potential of temozolomide is considered to be ...
Shaikh Asim, Masood Nehal
doaj   +1 more source

Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.

PLoS ONE, 2019
Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka, Tsutomu Nakazawa, Mitsutoshi Nakamura, Fumihiko Nishimura, Ryosuke Matsuda, Koji Omoto, Yoichi Shida, Toshiharu Murakami, Ichiro Nakagawa, Yasushi Motoyama, Hiromichi Morita, Takahiro Tsujimura, Hiroyuki Nakase   +12 more
doaj   +1 more source

A Strategy for Imidazotetrazine Prodrugs with Anti-cancer Activity Independent of MGMT and MMR

, 2012
The imidazotetrazine ring is an acid-stable precursor and prodrug of highly-reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The
Hartley, J.A., Wheelhouse, Richard T., Li, Li, Garelnabi, EAE, Li, L, Elrashied A. E. Garelnabi, Kiakos, K, Wheelhouse, RT, Garelnabi, Elrashied A.E., Richard T. Wheelhouse, Roger M. Phillips, Hartley, JA, Phillips, Roger M., Nazira Karodia, Pletsas, D, Karodia, N, Dimitrios Pletsas, Kiakos, K., Karodia, Nazira, Phillips, Roger, Pletsas, Dimitrios, Li Li, Konstantinos Kiakos, John A. Hartley   +23 more
core   +1 more source

A novel 3D in vitro model of glioblastoma reveals resistance to temozolomide which was potentiated by hypoxia [PDF]

, 2019
PurposeGlioblastoma (GBM) is the most common invasive malignant brain tumour in adults. It is traditionally investigated in vitro by culturing cells as a monolayer (2D culture) or as neurospheres (clusters enriched in cancer stem cells) but neither ...
Musah-Eroje, Ahmed, Watson, Sue
core   +1 more source

GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide

Frontiers in Oncology, 2022
Glioblastoma is a highly lethal grade of astrocytoma with very low median survival. Despite extensive efforts, there is still a lack of alternatives that might improve these prospects. We uncovered that the chemotherapeutic agent temozolomide impinges on
Sweta Parik, Sweta Parik, Sweta Parik, Sweta Parik, Juan Fernández-García, Juan Fernández-García, Francesca Lodi, Francesca Lodi, Karen De Vlaminck, Karen De Vlaminck, Marleen Derweduwe, Steven De Vleeschouwer, Raf Sciot, Wietse Geens, Linqian Weng, Francesca Maria Bosisio, Francesca Maria Bosisio, Gabriele Bergers, Gabriele Bergers, Johnny Duerinck, Frederick De Smet, Diether Lambrechts, Diether Lambrechts, Jo A. Van Ginderachter, Jo A. Van Ginderachter, Sarah-Maria Fendt, Sarah-Maria Fendt   +26 more
doaj   +1 more source

Hypofractionated Radiation Therapy with Temozolomide for Patients with Glioblastoma Multiforme Recursive Partitioning Analyzes Class V and VI

Southern Clinics of Istanbul Eurasia, 2019
INTRODUCTION[|]This study was performed to determine whether adjuvant temozolomide and 45 Gy/15 fr hypofractionated radiotherapy (RT) can be used to shorten the treatment duration in glioblastoma multiforme (GBM) patients with poor prognostic factors ...
Fuzuli Tuğrul, Gokhan Yaprak, Atilla Arslankaya, Naciye Işık   +3 more
doaj   +1 more source

Novel therapeutic venues for glioblastoma: novel rising preclinical treatment opportunities [PDF]

, 2011
High grade gliomas, including anaplastic glioma WHO grade III and glioblastoma WHO IV (GBM), carry a dismal prognosis. Taking all nowadays-available therapeutics options, including radiation, chemotherapy and surgery, for GBM into consideration the ...
Siegelin, Yasemin, Siegelin Yasemi, Siegelin, Markus David, Siegelin Markus David, Siegelin Yasemin, Siegelin Markus   +5 more
core   +1 more source