Results 31 to 40 of about 77,174 (152)

Hypofractionated Radiation Therapy with Temozolomide for Patients with Glioblastoma Multiforme Recursive Partitioning Analyzes Class V and VI

Southern Clinics of Istanbul Eurasia, 2019
INTRODUCTION[|]This study was performed to determine whether adjuvant temozolomide and 45 Gy/15 fr hypofractionated radiotherapy (RT) can be used to shorten the treatment duration in glioblastoma multiforme (GBM) patients with poor prognostic factors ...
Fuzuli Tuğrul, Gokhan Yaprak, Atilla Arslankaya, Naciye Işık   +3 more
doaj   +1 more source

The challenges of managing glioblastoma multiforme in developing countries: a trade-off between cost and quality of care

Hematology/Oncology and Stem Cell Therapy, 2011
BACKGROUND AND OBJECTIVES: The management of glioblastoma multiforme (GBM) in developing countries is hindered by the paucity of clear protocols due in part to growing economic constraints and the lack of availability of expensive chemotherapeutic agents.
Ahmed Salem, Sameh A. Hashem, Abdulla Al-Rashdan, Najeeb Ezam, Ala’a Nour, Amer Alsharbaji, Maher Sughayer, Issa Mohamad, Maher Elyan, Ala’a Addas, Maysa Al-Hussaini, Abdelatif Almousa   +11 more
doaj   +1 more source

Lymphoproliferative disorder during temozolomide therapy; a representative case of a formidable complication and management challenges

BMC Neurology, 2023
Background Lymphoproliferative disorder represents a heterogeneous clinicopathological spectrum characterized by uncontrolled proliferation of lymphocytes. Immunodeficiency is a major trigger of its development.
Daisuke Sato, Hirokazu Takami, Shunsaku Takayanagi, Kazuki Taoka, Mariko Tanaka, Reiko Matsuura, Shota Tanaka, Nobuhito Saito   +7 more
doaj   +1 more source

Efficacy of temozolomide in children with solid tumors

, 2020
Temozolomide, an alkylating drug first adopted to treat patients with malignant gliomas, is actually an antineoplastic drug used in various regimens against childhood tumors. Treatment with temozolomide is an effective therapy for different childhood
Ruggiero A., Mastrangelo S., Maurizi P.
core   +1 more source

Temozolomide-induced increase of tumorigenicity can be diminished by targeting of mitochondria in in vitro models of patient individual glioblastoma. [PDF]

PLoS ONE, 2018
Glioblastoma multiforme (GBM) is a highly heterogeneous and aggressive brain tumor with a dismal prognosis. Development of resistance towards cytostatic drugs like the GBM standard drug temozolomide is a severe problem in GBM treatment.
Doreen William, Madlin Walther, Björn Schneider, Michael Linnebacher, Carl Friedrich Classen   +4 more
doaj   +1 more source

Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres

Biomolecules, 2019
Temozolomide is the current first-line treatment for glioblastoma patients but, because many patients are resistant to it, there is an urgent need to develop antitumor agents to treat temozolomide-resistant glioblastoma.
Hee Yeon Kim, Byung Il Lee, Ji Hoon Jeon, Dong Keon Kim, Seok-Gu Kang, Jin-Kyoung Shim, Soo Youl Kim, Sang Won Kang, Hyonchol Jang   +8 more
doaj   +1 more source

Temozolomide alleviates breast carcinoma via the inhibition of EGFR/ERK/ MMP-1 pathway with induction of apoptotic events

Acta Cirúrgica Brasileira
Purpose: To evaluate the chemotherapeutic activity of temozolomide counter to mammary carcinoma. Methods: In-vitro anticancer activity has been conducted on MCF7 cells, and mammary carcinoma has been induced in Wistar rats by introduction of 7, 12 ...
Weijun Zhu, Fengjun Zhang, Maoyun Wang, Shuai Meng, Fang Ren   +4 more
doaj   +1 more source

Synergistic effect of perampanel with temozolomide on glioblastoma cells in vivo

Heliyon
The anti-epileptic drug perampanel, an α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor antagonist, exhibits anti-tumor effects against glioblastoma cells in vitro.
Takuma Nishide, Shun Yamamuro, Emiko Sano, Yumi Aida, Kaoru Nara, Genki Yazawa, Yoshinari Ozawa, Atsuo Yoshino   +7 more
doaj   +1 more source

Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2

Neoplasia: An International Journal for Oncology Research, 2018
The anticancer drug temozolomide is the only drug with proven activity against high-grade gliomas and has therefore become a part of the standard treatment of these tumors.
Mark C. de Gooijer, Nienke A. de Vries, Tessa Buckle, Levi C.M. Buil, Jos H. Beijnen, Willem Boogerd, Olaf van Tellingen   +6 more
doaj   +1 more source

Supplementary Data from MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide Resistance

, 2009
Supplementary Data from MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide ...
Jiangyong Miao (14899617), Ken Aldape (11929683), Catherine L. Nutt (14871065), David N. Louis (14871071), Daniel P. Cahill (5693057), A. John Iafrate (8756931), Stephen Yip (675979)   +6 more
core   +1 more source