Results 51 to 60 of about 77,174 (152)

DNA Triplex-Formation by a Covalent Conjugate of the Anticancer Drug Temozolomide

DNA
Background/Objectives: Temozolomide is an important drug used for the treatment of glioblastoma multiforme. Covalent conjugation of temozolomide to triplex-forming oligonucleotides could facilitate better sequence discrimination when targeted to DNA to ...
Andrew J. Walsh, William Fraser
doaj   +1 more source

Non-Hodgkin Lymphoma after Treatment with Extended Dosing Temozolomide and Radiotherapy for a Glioblastoma: A Case Report

Case Reports in Oncology, 2013
Temozolomide (TMZ) is an alkylating agent, used for the treatment of high-grade gliomas. This case report describes the development of a non-Hodgkin lymphoma in a patient treated with extended-dose temozolomide and radiotherapy.
Laura Van Ginderachter, Tony Cox, Ria Drijkoningen, Ruth Achten, Eric Joosens, Annelies Maes, Koen Theunissen, Jeroen Mebis   +7 more
doaj   +1 more source

Combining VELIPARIB (ABT-888) with temozolomide shows strong synergy when treating temozolomide-resistant and recurrent GBM cell lines

, 2014
Combining VELIPARIB (ABT-888) with temozolomide shows strong synergy when treating temozolomide-resistant and recurrent GBM cell ...
K McDonald (9898670), K Nozue-Okada (13683709), M Khasraw (12897953)   +2 more
core  

Outcome of Combined Temozolomide/CCNU versus Temozolomide (Standard or Extended) For Patients with Methylated MGMT Glioblastoma

Glioblastoma treatment is a real challenge despite better understanding of molecular characterization of gliomas. More effective treatment protocols are urgently required.
Fatma Gharib, Ahmed El hamouly, Nehal K.H. Kamel, Asma M. Elkady   +3 more
core   +1 more source

Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta

iScience
Summary: Resistance to chemotherapies such as temozolomide is a major hurdle to effectively treat therapy-resistant glioblastoma. This challenge arises from the activation of phosphatidylinositol 3-kinase (PI3K), which makes it an appealing therapeutic ...
Kevin J. Pridham, Kasen R. Hutchings, Patrick Beck, Min Liu, Eileen Xu, Erin Saechin, Vincent Bui, Chinkal Patel, Jamie Solis, Leah Huang, Allison Tegge, Deborah F. Kelly, Zhi Sheng   +12 more
doaj   +1 more source

Temozolomide in the management of dopamine agonist-resistant prolactinomas

, 2012
Background  The majority of prolactinomas respond to dopamine agonist therapy, but a proportion are resistant, requiring other treatments including surgery and/or radiotherapy.
King, A. P., Dworakowska, D., Thomas, N. W., Lipscomb, D., Buchanan, C. R., Barazi, S., Hampton, T., Gilbert, J. A., Aylwin , S. J. B., Riordan-Eva, P., Landau, D. B., Whitelaw, B. C.   +11 more
core   +1 more source

Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms. [PDF]

, 2006
PURPOSE: In this study, we investigated the mechanisms by which temozolomide enhances radiation response in glioblastoma cells. EXPERIMENTAL DESIGN: Using a panel of four primary human glioblastoma cell lines with heterogeneous O(6)-methylguanine-DNA ...
Gilbert, M.R., Mehta, M., Chakravarti, A., Erkkinen, M.G., Stupp, R., Loeffler, J.S., Nestler, U., Aldape, K., Black, P.M.   +8 more
core   +1 more source

Lomitapide enhances cytotoxic effects of temozolomide in chemotherapy-resistant glioblastoma

JCI Insight
More than a third of patients with glioblastoma experience tumor progression during adjuvant therapy. In this study, we performed a high-throughput drug repurposing screen of FDA-approved agents capable of crossing the blood-brain barrier in order to ...
Alyona Ivanova, Taylor M. Wilson, Kimia Ghannad-Zadeh, Esmond Tse, Robert Flick, Megan Wu, Sunit Das   +6 more
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Prognostic significance of concomitant radiotherapy in newly diagnosed glioblastoma multiforme: a multivariate analysis of 116 patients

Annals of Saudi Medicine, 2012
BACKGROUND AND OBJECTIVES: Currently, radiotherapy with concomitant and adjuvant temozolomide has become the standard treatment for glioblastoma. The purpose of this study was to report our experience with radiation plus concomitant temozolomide in 116 ...
Nilgun Ozbek Okumus, Bilge Gursel, Deniz Meydan, Ozge Ozdemir, Eylem Odabası, Guzin Gonullu   +5 more
doaj   +1 more source

Progress of temozolomide in the treatment of recurrent high-grade gliomas

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
High-grade gliomas are central nervous system malignancies which are difficult to treat. Surgery, temozolomide combined with radiotherapy postoperatively and adjuvant chemotherapy with temozolomide have been established as the standard treatment options ...
Jin-duo LI, Rong JIANG, Jin-huan WANG, Bin WANG, Chun-hua MA, Li-wei SUN, Yuan LÜ, Guo-fang HOU   +7 more
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