Results 61 to 70 of about 61,558 (234)

Prognostic significance of concomitant radiotherapy in newly diagnosed glioblastoma multiforme: a multivariate analysis of 116 patients

Annals of Saudi Medicine, 2012
BACKGROUND AND OBJECTIVES: Currently, radiotherapy with concomitant and adjuvant temozolomide has become the standard treatment for glioblastoma. The purpose of this study was to report our experience with radiation plus concomitant temozolomide in 116 ...
Nilgun Ozbek Okumus, Bilge Gursel, Deniz Meydan, Ozge Ozdemir, Eylem Odabası, Guzin Gonullu   +5 more
doaj   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta

iScience
Summary: Resistance to chemotherapies such as temozolomide is a major hurdle to effectively treat therapy-resistant glioblastoma. This challenge arises from the activation of phosphatidylinositol 3-kinase (PI3K), which makes it an appealing therapeutic ...
Kevin J. Pridham, Kasen R. Hutchings, Patrick Beck, Min Liu, Eileen Xu, Erin Saechin, Vincent Bui, Chinkal Patel, Jamie Solis, Leah Huang, Allison Tegge, Deborah F. Kelly, Zhi Sheng   +12 more
doaj   +1 more source

In vitro therapy against glioblastoma cells by 3-Dezaneplanocin-A, panobinostat, and temozolomide

Glioma, 2018
Background: Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. Current treatment against this tumor consists of maximal surgical resection without threatening the patient's life, followed by a treatment with temozolomide, with or ...
Javier de la Rosa, Alejandro Urdiciain, Bárbara Meléndez, Juan A Rey, Miguel A Idoate, Javier S Castresana   +5 more
doaj   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Progress of temozolomide in the treatment of recurrent high-grade gliomas

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
High-grade gliomas are central nervous system malignancies which are difficult to treat. Surgery, temozolomide combined with radiotherapy postoperatively and adjuvant chemotherapy with temozolomide have been established as the standard treatment options ...
Jin-duo LI, Rong JIANG, Jin-huan WANG, Bin WANG, Chun-hua MA, Li-wei SUN, Yuan LÜ, Guo-fang HOU   +7 more
doaj  

Non-Hodgkin Lymphoma after Treatment with Extended Dosing Temozolomide and Radiotherapy for a Glioblastoma: A Case Report

Case Reports in Oncology, 2013
Temozolomide (TMZ) is an alkylating agent, used for the treatment of high-grade gliomas. This case report describes the development of a non-Hodgkin lymphoma in a patient treated with extended-dose temozolomide and radiotherapy.
Laura Van Ginderachter, Tony Cox, Ria Drijkoningen, Ruth Achten, Eric Joosens, Annelies Maes, Koen Theunissen, Jeroen Mebis   +7 more
doaj   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Lomitapide enhances cytotoxic effects of temozolomide in chemotherapy-resistant glioblastoma

JCI Insight
More than a third of patients with glioblastoma experience tumor progression during adjuvant therapy. In this study, we performed a high-throughput drug repurposing screen of FDA-approved agents capable of crossing the blood-brain barrier in order to ...
Alyona Ivanova, Taylor M. Wilson, Kimia Ghannad-Zadeh, Esmond Tse, Robert Flick, Megan Wu, Sunit Das   +6 more
doaj   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source