Results 61 to 70 of about 77,174 (152)

In vitro therapy against glioblastoma cells by 3-Dezaneplanocin-A, panobinostat, and temozolomide

Glioma, 2018
Background: Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. Current treatment against this tumor consists of maximal surgical resection without threatening the patient's life, followed by a treatment with temozolomide, with or ...
Javier de la Rosa, Alejandro Urdiciain, Bárbara Meléndez, Juan A Rey, Miguel A Idoate, Javier S Castresana   +5 more
doaj   +1 more source

Long-term use of temozolomide : could you use temozolomide safely for life in gliomas?

, 2009
Long-term use of temozolomide : could you use temozolomide safely for life in ...
D Bell (8736168), H Wheeler (13311603), Mustafa Khasraw (13078896)   +2 more
core  

The Effect of Ascorbic Acid over the Etoposide- and Temozolomide-Mediated Cytotoxicity in Glioblastoma Cell Culture: A Molecular Study

, 2018
AIm: Glioblastoma (GBM) is one of the lethal central nervous system tumors. One of the widely used chemical agents for the treatment of glioblastoma is temozolomide. It is an orally administered, deoxyribonucleic acid (DNA) alkylating agent.
Seda Ceylan, Dilek Gokturk, Gokturk, Dilek, Yilmaz, Dervis Mansuri, Kelebek, Haşim, Ceylan, Seda, Dervis Mansuri Yılmaz, Hasim Kelebek   +7 more
core   +2 more sources

Salvage nivolumab plus temozolomide associated with improved survival and clinical benefit in refractory melanoma: a retrospective cohort study

Frontiers in Oncology
IntroductionPatients with metastatic melanoma who progress on standard of care therapy have limited treatment options. This study evaluates the efficacy of nivolumab combined with temozolomide compared to temozolomide alone in this refractory setting ...
Preethy E. Abraham, Kun Bai, Sheau-Chiann Chen, Douglas B. Johnson   +3 more
doaj   +1 more source

Advances in the management of glioblastoma: the role of temozolomide and MGMT testing

, 2012
Reena P Thomas, Lawrence Recht, Seema NagpalDepartment of Neurological Sciences, Stanford University Hospital, Stanford, CA, USAAbstract: Glioblastoma (GB) is one of the most lethal forms of cancer, with an invasive growth pattern that requires the use ...
Thomas RP, Recht L, Nagpal S
core  

Synergistic Effects of Temozolomide and Doxorubicin in the Treatment of Glioblastoma Multiforme: Enhancing Efficacy through Combination Therapy

Molecules
Glioblastoma multiforme (GBM), a grade IV (WHO classification) malignant brain tumor, poses significant challenges in treatment. The current standard treatment involves surgical tumor removal followed by radiation and chemotherapeutic interventions ...
Laxmi Dhungel, Mandy E. Rowsey, Cayla Harris, Drazen Raucher   +3 more
doaj   +1 more source

Temozolomide-loaded bacterial magnetosomes improve targeted therapy for brain tumors [PDF]

Novel active-targeting nano-therapeutic, Temozolomide-loaded magnetosomes conjugate has been developed to address the challenges of high metastatic rates and recurrence of tumors due to tumor circulating cells.
Ahmad, Laiba, Albekairi, Thamer H., Rauf, Shumaila, Rabbi, Fazle, Iriti, Marcello, Nisar, Amna, Albekairi, Norah A., Alshammari, Abdulrahman, Rauf, Abdur   +8 more
core   +1 more source

DNA methylation remodeling in temozolomide resistant recurrent glioblastoma: comparing epigenetic dynamics in vitro and in vivo

Journal of Translational Medicine
Background Glioblastoma is the most aggressive type of brain tumor and is associated with a poor prognosis. First-line treatment is surgical resection followed by radiotherapy and temozolomide-based chemotherapy.
Michela Buonaiuto, Mariella Cuomo, Davide Costabile, Federica Trio, Sara Ferraro, Ornella Affinito, Alberto De Bellis, Maria Laura Del Basso De Caro, Roberta Visconti, Lorenzo Chiariotti, Giuseppe Catapano, Rosa Della Monica   +11 more
doaj   +1 more source

Carbonic anhydrase XII inhibitors overcome P-glycoprotein–mediated resistance to temozolomide in glioblastoma

, 2018
The role of carbonic anhydrase XII (CAXII) in the chemoresistance of glioblastoma is unexplored. We found CAXII and P-glycoprotein (Pgp) coexpressed in neurospheres derived from 3 of 3 patients with different genetic backgrounds and low response to ...
Mujumdar, P, Annovazzi, L, Schiffer, D, Salaroglio, IC, Mellai, M, Poulsen, SA, Riganti, C, Kopecka, J   +7 more
core   +1 more source

hsa-miR-34a-5p enhances temozolomide anti-tumoral effects on glioblastoma

EXCLI Journal : Experimental and Clinical Sciences
Glioblastoma multiform (GBM) is a commonly diagnosed brain neoplasm with a poor prognosis. Accumulating evidence has highlighted the significance of microRNA (miR) dysregulation in tumor development and progression.
Mahdi Abdoli Shadbad, Amir Baghbanzadeh, Behzad Baradaran   +2 more
doaj   +1 more source