Results 71 to 80 of about 77,174 (152)

Temozolomide in pediatric low-grade glioma

, 2007
Temozolomide in pediatric low-grade ...
LT Coleman (15875966), PA Downie (15875279), SL Khaw (15875963), JA Heath (15875225), DM Ashley (14452374)   +4 more
core  

Circadian rhythms in pediatric high-grade gliomas may contribute to treatment efficacy

Scientific Reports
Pediatric high-grade gliomas (pHGG) are highly invasive with poor survival outcomes. Timing of Temozolomide administration has been shown to affect survival of adult patients with glioblastoma.
Ella A. Nettnin, Cesar A. Garcia, Fudhial F. Sayed, Ethan Schonfeld, Thien Nguyen, Maria Isabel Barros Guinle, Claudia K. Petritsch, Erin M. Gibson, Laura M. Prolo   +8 more
doaj   +1 more source

Preclinical NCI-MPACT: prospective modeling of the mutation-based NCI-MPACT clinical trial therapeutic strategy in patient-derived xenograft models

Frontiers in Oncology
PurposeThe National Cancer Institute’s Molecular Profiling-Based Assignment of Cancer Therapy (NCI-MPACT) randomized phase 2 clinical trial assessed the utility of applying tumor DNA sequencing to treatment selection.
Yvonne A. Evrard, Sergio Y. Alcoser, Michael Mullendore, Li Chen, Chih-Jian Lih, Vishnuprabha Rahul Kannan, Vivekananda Datta, Lindsay Dutko, Shahanawaz Jiwani, Lawrence V. Rubinstein, Yingdong Zhao, P. Mickey Williams, Alida Palmisano, Alida Palmisano, Laura Kuhlmann, Mel Simpson, Shivaani Kummar, Biswajit Das, Chris Karlovich, Eric Polley, Ming-Chung Li, Alice P. Chen, Melinda G. Hollingshead, James H. Doroshow, James H. Doroshow   +24 more
doaj   +1 more source

Severe cholestatic hepatitis due to temozolomide: an adverse drug effect to keep in mind. Case report and review of literature

, 2015
Temozolomide is the current standard of therapy for postoperative patients with glioblastoma starting adjuvant radiotherapy. Hematologic adverse events are the most frequent side effects of temozolomide, while liver toxicity has been reported only in the
Grieco, Antonio, Vecchio, FM, Miele, L, Miele, L., Biolato, M   +4 more
core   +1 more source

Temozolomide for the Treatment of Metastatic Melanoma

, 2007
Questions: What is the role of single-agent temozolomide in the treatment of patients with metastatic melanoma? In comparison with single-agent temozolomide, does the addition of interferon-α to temozolomide improve disease-free survival, overall ...
I. Quirbt, T. Petrella, S. Verma, M. Charette, K. Bak   +4 more
core   +1 more source

Mammalian target of rapamycin inhibition protects glioma cells from temozolomide-induced cell death

Cell Death Discovery
Glioblastoma is an incurable brain tumor with a median survival below two years. Trials investigating targeted therapy with inhibitors of the kinase mTOR have produced ambiguous results.
Benedikt Sauer, Nadja I. Lorenz, Iris Divé, Kevin Klann, Anna-Luisa Luger, Hans Urban, Jan-Hendrik Schröder, Joachim P. Steinbach, Christian Münch, Michael W. Ronellenfitsch   +9 more
doaj   +1 more source

Hyperoxia resensitizes chemoresistant glioblastoma cells to temozolomide through unfolded protein response

, 2014
Background: Intratumoural hypoxia is associated with chemoresistance in glioblastoma multiforme (GBM), a highly malignant brain tumour. Adaptive response to endoplasmic reticulum stress induced by temozolomide is a major obstacle in recurrent GBM.
Sun, Stella, Ho, Amy S.W., Zhang, Xiao Qin, Xu, Fei Fan, Lee, Derek, Kiang, Karrie M.Y., Leung, Gilberto K.K.   +6 more
core  

Temozolomide for high grade glioma [PDF]

, 2013
BACKGROUND: High grade glioma (HGG) is an aggressive form of brain cancer. Treatment of HGG usually entails biopsy, or resection if safe, followed by radiotherapy.
G Rogers (3098445), R Grant (7320581), R Garside (15857750), Ken Stein (467679), MG Hart (19742755)   +4 more
core  

The effect of temozolomide as consolidation chemotherapy on treatment results of glioblastoma multiforme patients treated with concomittant radiotherapy and temozolomide

, 2008
This retrospective study was performed to determine the efficacy of adjuvant temozolomide after radiotherapy with concomitant temozolomide in patients with newly diagnosed glioblastome ...
Soyuer, Serdar, Kaplan, Buenyamin, EROĞLU, Celalettin, ÖZKAN, Metin, YILDIZ, Oguz G., Menku, Ahmet, Orhan, Okan   +6 more
core   +1 more source

Chlorpromazine overcomes temozolomide resistance in glioblastoma by inhibiting Cx43 and essential DNA repair pathways

Journal of Translational Medicine
Background In the fight against GBM, drug repurposing emerges as a viable and time-saving approach to explore new treatment options. Chlorpromazine, an old antipsychotic medication, has recently arisen as a promising candidate for repositioning in GBM ...
Paola Matarrese, Michele Signore, Barbara Ascione, Giulia Fanelli, Marco G. Paggi, Claudia Abbruzzese   +5 more
doaj   +1 more source