Results 41 to 50 of about 70,369 (254)

Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres

Biomolecules, 2019
Temozolomide is the current first-line treatment for glioblastoma patients but, because many patients are resistant to it, there is an urgent need to develop antitumor agents to treat temozolomide-resistant glioblastoma.
Hee Yeon Kim, Byung Il Lee, Ji Hoon Jeon, Dong Keon Kim, Seok-Gu Kang, Jin-Kyoung Shim, Soo Youl Kim, Sang Won Kang, Hyonchol Jang   +8 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma [PDF]

, 2017
IMPORTANCE Tumor-treating fields (TTFields) is an antimitotic treatment modality that interferes with glioblastoma cell division and organelle assembly by delivering low-intensity alternating electric fields to the tumor.
Kim, C.Y., Ahluwalia, M.S., Hegi, Monika E., Tran, David D, Gitit Lavy-Shahaf, Di Meco, Francesco, Stragliotto, Giuseppe, Hegi, M.E., Tran, D.D., William Read, Zhu, Jay-Jiguang, Steinberg, David, Kim, Chae-Yong, Idbaih, Ahmed, Hegi, Monika E, Nicholas, Garth, Kanner, A., Tran, David, Toms, Steven, Monika E. Hegi, Fink, Karen, Taillibert, S., Hirte, Hal, Fink, K., Palti, Y., Di Meco, F., Andreas F. Hottinger, David M. Steinberg, Weinberg, U., Steinberg, David M, Hirte, H., Andrew Kanner, Idbaih, A., Lhermitte, Benoit, Burna, Jordi, Kirson, Eilon, Steven Brem, Weller, M., Uri Weinberg, Sophie Taillibert, Lieberman, Frank, Yoram Palti, Francesco Di Meco, Weller, Michael, Stupp, R., Stupp, Roger, David D. Tran, Lavy-Shahaf, Gitit, Taillibert, Sophie, Lavy-Shahaf, G., Stragliotto, G., Manmeet S. Ahluwalia, Ahluwalia, Manmeet, Lieberman, F., Benoit Lhermitte, Ram, Zvi, Hottinger, A.F., Jordi Bruna, Ahluwalia, Manmeet S., Karen Fink, Sun-Ha Paek, Weinberg, Uri, Frank Lieberman, Lhermitte, B., Kanner, Andrew, Toms, S., Michael Weller, Hegi, Monika, Kirson, Eilon D, Hal Hirte, Eilon D. Kirson, Paek, Sun-Ha, Brem, S., Palti, Yoram, Hottinger, Andreas, Chae-Yong Kim, Steven Toms, Ahluwalia, Manmeet S, Zvi Ram, Jay-Jiguang Zhu, Kirson, E.D., Brem, Steven, Nicholas, G., Zhu, J.J., Burna, J., Ram, Z., Bruna, Jordi, Read, William, Hottinger, Andreas F, Roger Stupp, Giuseppe Stragliotto, Read, W., Ahmed Idbaih, Steinberg, D.M., Garth Nicholas, Kirson, Eilon D., Paek, S.H.   +96 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Temozolomide alleviates breast carcinoma via the inhibition of EGFR/ERK/ MMP-1 pathway with induction of apoptotic events

Acta Cirúrgica Brasileira
Purpose: To evaluate the chemotherapeutic activity of temozolomide counter to mammary carcinoma. Methods: In-vitro anticancer activity has been conducted on MCF7 cells, and mammary carcinoma has been induced in Wistar rats by introduction of 7, 12 ...
Weijun Zhu, Fengjun Zhang, Maoyun Wang, Shuai Meng, Fang Ren   +4 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Temozolomid und pegyliertes liposomales Doxorubicin in Kombination mit Strahlentherapie in der Ersttherapie von Patienten mit Glioblastom WHO Grad IV – eine Phase I/II – Studie (RNOP – 09)

, 2011
Hintergrund: Die EORTC26981/NCIC-CE.3-Studie hatte 2005 zur Etablierung eines neuen Standard-Therapieregimes für das Glioblastom geführt. Obwohl sich Temozolomid hierbei als wirksames Agens gezeigt hatte, bleibt die Prognose für diese Entität sehr ...
Schmid, Christina
core   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source