Development of a Clinically Relevant Temozolomide-Resistant Human Glioblastoma A-172 Cell Line
Background: Glioblastoma is the most aggressive and deadly form of brain cancer, with a median survival of approximately 14 months. A major factor contributing to an unfavorable prognosis is the development of resistance to temozolomide (TMZ), the current first-line chemotherapeutic drug for glioblastoma. Thus, developing reliable preclinical models of
Pajović, Milica +7 more
core +7 more sources
Development and validation of a machine learning-based survival prediction model for Asian glioblastoma patients using the SEER database and Chinese data [PDF]
Scientific ReportsGlioblastoma is an aggressive, malignant primary brain tumour and the most prevalent histological type of glioma. Our study attempted to investigate the independent predictors of overall survival (OS) and cancer-specific survival (CSS) in Asian patients ...
Denglin Li +8 more
doaj +2 more sources
Novel Treatment Strategies for Glioblastoma [PDF]
, 2021 This book is a compilation of articles that brings together current knowledge from an international team of contributors who are dedicated investigators exploring novel strategies for the treatment of glioblastoma.
core +2 more sources
Cancer Neuroscience: From Local Neuro–Immune Microenvironments to Systemic Brain–Body Circuitry [PDF]
MedComm, Volume 7, Issue 9, September 2026.This review outlines the cancer neuroscience paradigm, spanning systemic brain–body circuitry and local neuro–immune–tumor microenvironments. We discuss how tumors promote axonogenesis and pseudo‐synapse formation, and how sensory neuropeptides, such as CGRP, contribute to CD8+ T‐cell exhaustion.
Mingxuan Xie +7 more
wiley +2 more sources
Non-operable glioblastoma: Proposition of patient-specific forecasting by image-informed poromechanical model [PDF]
, 2023 Work funding with a grant fromLuxembourg National Research Fund (FNR) grant number INTER/ANR/21/16399490 and from Réseau Santé des Arts et Métiers.We propose a novel image-informed glioblastoma mathematical model within a reactive multiphase ...
ROHAN, Pierre-Yves +14 more
core +1 more source
Journal of Functional Biomaterials, 2020 The extracellular cell surface-associated and soluble heat shock protein 90 (Hsp90) is known to participate in the migration and invasion of tumor cells.
Anastasiya V. Snigireva +8 more
doaj +1 more source
Targeted intracellular delivery of resveratrol to glioblastoma cells using apolipoprotein E-containing reconstituted HDL as a nanovehicle. [PDF]
PLoS ONE, 2015 The objective of this study is to transport and deliver resveratrol to intracellular sites using apolipoprotein E3 (apoE3). Reconstituted high-density lipoprotein (rHDL) bearing resveratrol (rHDL/res) was prepared using phospholipids and the low-density ...
Sea H Kim +5 more
doaj +1 more source
CK2 Inhibition and Antitumor Activity of 4,7-Dihydro-6-nitroazolo[1,5-a]pyrimidines
Molecules, 2022 Today, cancer is one of the most widespread and dangerous human diseases with a high mortality rate. Nevertheless, the search and application of new low-toxic and effective drugs, combined with the timely diagnosis of diseases, makes it possible to cure ...
Daniil N. Lyapustin +11 more
doaj +1 more source
Synthesis of silver nanoparticles using Salvia officinalis extract: Structural characterization, cytotoxicity, antileishmanial and antimicrobial activity [PDF]
Nanomedicine Research Journal, 2020 Objective: This study aimed to investigate the cytotoxicity, antileishmanial and antibacterial potential of silver nanoparticles (AgNPs) synthesized by (Salvia officinalis L. (Sage)) extract.
Fatemeh Sharifi +4 more
doaj +1 more source
Cells, 2022 Lichens are a source of secondary metabolites with significant pharmacological potential. Data regarding their possible application in glioblastoma (GBM) treatment are, however, scarce.
Aleksandra Majchrzak-Celińska +9 more
doaj +1 more source