Results 1 to 10 of about 33,845 (238)

Effects of NDRG2 Overexpression on Metastatic Behaviors of HCT116 Colorectal Cancer Cell Line [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: N-myc downstream-regulated gene 2 (NDRG2) is frequently down-regulated in cancer, and plays an important role in the control of tumor growth and metastasis. Its manipulation has been suggested as a therapy in cancer.
Ali Golestan, Abbas Ghaderi, Zahra Mojtahedi   +2 more
doaj   +5 more sources

Terfenadine, a histamine H1 receptor antagonist, induces apoptosis by suppressing STAT3 signaling in human colorectal cancer HCT116 cells [PDF]

Frontiers in Pharmacology
IntroductionColorectal cancer is a highly aggressive and metastatic cancer with inadequate clinical outcomes. Given the crucial role of histamine and histamine receptors in colorectal carcinogenesis, this study aimed at exploring the anticancer effects ...
Manoj Kumar Baniya, Eun-Hee Kim, Kyung-Soo Chun   +2 more
doaj   +4 more sources

Inhibition of Mitochondrial Dynamics by Mitochondrial Division Inhibitor-1 Suppresses Cell Migration and Metastatic Markers in Colorectal Cancer HCT116 Cells [PDF]

Journal of Experimental Pharmacology
Tahir Mehmood,1,2 Qandeel Nasir,2 Iqra Younis,2 Chatchai Muanprasat1 1Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangpla, Bangplee, Samut Prakarn, Thailand; 2Department of Biological Sciences ...
Mehmood T, Nasir Q, Younis I, Muanprasat C   +3 more
doaj   +4 more sources

B7-H1 Expression Is Associated with Poor Prognosis in Colorectal Carcinoma and Regulates the Proliferation and Invasion of HCT116 Colorectal Cancer Cells

PLoS ONE, 2013
The investigation concerning the B7-H1 expression in colorectal cancer cells is at an early stage. It is unclear whether B7-H1 expression may have diagnostic or prognostic value in colorectal carcinoma. Additionally, how B7-H1 is associated with the clinical features of colorectal carcinoma is not known. In order to investigate the relationship between
Yan-Ling Meng, An-Gang Yang, Wei-Hong Wen   +2 more
exaly   +6 more sources

Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells. [PDF]

Oncol Lett, 2020
Histone deacetylase (HDAC) inhibitors and DNA alkylators are effective components of combination chemotherapy. The aim of the present study was to investigate the possible mechanism of their synergism by detecting the effect of HDAC inhibitors on the expression levels of drug transporters that export DNA alkylators.
Shi B, Xu FF, Xiang CP, Jia R, Yan CH, Ma SQ, Wang N, Wang AJ, Fan P.   +8 more
europepmc   +4 more sources

Deactivation of CK1α enhances the anti-cancer effects of salinomycin in colorectal cancer HCT116 cells. [PDF]

Biochem Biophys Rep
Salinomycin (Sal), an ion-carrier antibiotic, effectively suppresses cancer growth and metastasis through autophagy or ferroptosis induction, thereby overcoming drug resistance. D4476, a selective inhibitor of casein kinase 1 alpha (CK1α), also inhibits the growth of tumors.
Khakshournia S, Siri M, Zamani M, Bozorg-Ghalati F, Mojtahedi Z, Igder S, Azarpira N, Mokarram P.   +7 more
europepmc   +3 more sources

Scaphium affine Ethanol Extract Induces Anoikis by Regulating the EGFR/Akt Pathway in HCT116 Colorectal Cancer Cells

Frontiers in Oncology, 2021
Scaphium affine ethanol extracts (SAE) is a species that has been shown to contain various physiological effects; however, its anticancer effects have yet to be revealed.
Hye Won Kawk, Gun-He Nam, Myeong Jin Kim, Sang-Yong Kim, Young-Min Kim   +4 more
doaj   +3 more sources

Faecalibacterium prausnitzii Ameliorates Colorectal Tumorigenesis and Suppresses Proliferation of HCT116 Colorectal Cancer Cells

Biomedicines, 2022
Faecalibacterium prausnitzii is one of the most abundant commensals of gut microbiota that is not commonly administered as a probiotic supplement. Being one of the gut’s major butyrate-producing bacteria, its clinical significance and uses are on the rise and it has been shown to have anti-inflammatory and gut microbiota-modulating properties in the ...
Ifeoma Julieth Dikeocha, Abdelkodose Mohammed Al-Kabsi, Hsien-Tai Chiu, Mohammed Abdullah Alshawsh   +3 more
openaire   +5 more sources

Licochalcone C Inhibits the Growth of Human Colorectal Cancer HCT116 Cells Resistant to Oxaliplatin. [PDF]

Biomol Ther (Seoul)
Licochalcone C (LCC; PubChem CID:9840805), a chalcone compound originating from the root of Glycyrrhiza inflata, has shown anticancer activity against skin cancer, esophageal squamous cell carcinoma, and oral squamous cell carcinoma. However, the therapeutic potential of LCC in treating colorectal cancer (CRC) and its underlying molecular mechanisms ...
Lee SO, Joo SH, Lee JY, Kwak AW, Kim KT, Cho SS, Yoon G, Choi YH, Park JW, Shim JH.   +9 more
europepmc   +3 more sources

Investigation of the Cytotoxic and Antiproliferative Effects of Liposomal Daunorubicin on Human Colorectal Cancer (HCT116) Cell Line. [PDF]

Iran J Pharm Res
Background: The incidence of colorectal cancer is increasing globally. Daunorubicin (DNR), an anthracycline antibiotic, is effective against various cancers. The PI3K/AKT/mTOR signaling pathway is crucial in regulating cell growth and cancer growth.
Alaa Hadi-Al-Ward N, Ebrahimi M, Zare Karizi S.   +2 more
europepmc   +3 more sources