Metabolomic Signatures in Doxorubicin-Induced Metabolites Characterization, Metabolic Inhibition, and Signaling Pathway Mechanisms in Colon Cancer HCT116 Cells [PDF]
Metabolites, 2022 Doxorubicin (DOX) is a chemotherapeutic agent is used for various cancer cells. To characterize the chemical structural components and metabolic inhibition, we applied a DOX to HCT116 colon cancer cells using an independent metabolites profiling approach.
Raja Ganesan +2 more
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Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor [PDF]
FEBS Open BioPoly(ADP‐ribose) glycohydrolase (PARG) is a key enzyme involved in poly(ADP‐ribose) (PAR) degradation and is considered a potential anticancer target. We previously investigated resistance mechanisms to the PARG inhibitor PDD00017273 in human colorectal ...
Kaede Tsuda, Yoko Ogino, Akira Sato
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Frontiers in Oncology, 2021 Scaphium affine ethanol extracts (SAE) is a species that has been shown to contain various physiological effects; however, its anticancer effects have yet to be revealed.
Hye Won Kawk +4 more
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Inhibition of Mitochondrial Dynamics by Mitochondrial Division Inhibitor-1 Suppresses Cell Migration and Metastatic Markers in Colorectal Cancer HCT116 Cells [PDF]
Journal of Experimental PharmacologyTahir Mehmood,1,2 Qandeel Nasir,2 Iqra Younis,2 Chatchai Muanprasat1 1Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangpla, Bangplee, Samut Prakarn, Thailand; 2Department of Biological Sciences ...
Mehmood T +3 more
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Terfenadine, a histamine H1 receptor antagonist, induces apoptosis by suppressing STAT3 signaling in human colorectal cancer HCT116 cells [PDF]
Frontiers in PharmacologyIntroductionColorectal cancer is a highly aggressive and metastatic cancer with inadequate clinical outcomes. Given the crucial role of histamine and histamine receptors in colorectal carcinogenesis, this study aimed at exploring the anticancer effects ...
Manoj Kumar Baniya +2 more
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Role of stearoyl CoA desaturase 1 in resistance of colon cancer cells to 5-fluorouracil
Di-san junyi daxue xuebao, 2021 Objective To construct a 5-fluorouracil (5-FU)-resistant colon cancer cell line, and to investigate the role of stearoyl CoA desaturase 1 (SCD1) in the resistance of colon cancer cells to 5-FU.
ZHOU Hongxu, DONG Yan, LI Jianjun
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Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway [PDF]
Frontiers in Pharmacology, 2021 Lingfei Li, Yang Tian, Jun Sheng
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Lactobacillus casei UT1 Isolated from Northwest of Iran Traditional Curd Exerts Anti-proliferative and Apoptosis Inducing Effects in Human Colorectal Tumor HCT 116 Cells [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: The present study was mainly designed to assess anti-cancer effects of lactobacilli isolated from traditional dairy products, on HCT116 colorectal cancer cell lines.
Mitra Rabiei +2 more
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Activating mutations in β-catenin in colon cancer cells alter their interaction with macrophages; the role of snail. [PDF]
PLoS ONE, 2012 Tumor cells become addicted to both activated oncogenes and to proliferative and pro-survival signals provided by the abnormal tumor microenvironment. Although numerous soluble factors have been identified that shape the crosstalk between tumor cells and
Pawan Kaler +2 more
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Cancer Biology & Therapy, 2023 The possible anticancer activity of combination (M + E + F) of metformin (M), efavirenz (E), and fluoxetine (F) was investigated in normal HDF cells and HCT116 human colon cancer cells.
Beom-Goo Kang +13 more
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