Results 11 to 20 of about 47,486 (225)
Results in Chemistry, 2022 The Sorafenib tosylate (ST) emulsified drug delivery system (ST-SEDDS) was designed and characterized in response to the poor solubility and bioavailability of ST.
Sankha Bhattacharya +2 more
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Transcriptional regulation of the legumain gene by p53 in HCT116 cells [PDF]
Biochemical and Biophysical Research Communications, 2013 Legumain (EC 3.4.22.34) is an asparaginyl endopeptidase. Strong legumain activity was observed in the mouse kidney, and legumain was found to be highly expressed in tumors. We previously reported that bovine kidney annexin A2 was co-purified with legumain and that legumain cleaved the N-terminal region of annexin A2 at an Asn residue in vitro and in ...
Yamane, Takuya +9 more
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Induction of DR5-Dependent Apoptosis by PGA2 through ATF4-CHOP Pathway
Molecules, 2022 Prostaglandin (PG) A2, a cyclopentenone PG, induced apoptosis in both HCT116 and HCT116 p53 −/− cells. Although PGA2-induced apoptosis in HCT116 cells was dependent on the p53-DR5 pathway, the mechanism underlying PGA2-induced apoptosis in HCT116 p53 −/−
Kyeong-Min Park +4 more
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Procaine Induces Epigenetic Changes in HCT116 Colon Cancer Cells [PDF]
Genetics Research International, 2016 Colon cancer is the third most commonly diagnosed cancer in the world, and it is the major cause of morbidity and mortality throughout the world. The present study aimed at treating colon cancer cell line (HCT116) with different chemotherapeutic drug/drug combinations (procaine, vorinostat “SAHA,” sodium phenylbutyrate, erlotinib, and carboplatin). Two
Hussein Sabit +3 more
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YM155, specific survivin inhibitor, can enhance artesunate-induced cytotoxicity in HCT116 colon cancer cells [PDF]
Korean Journal of Clinical Oncology, 2020 Purpose A water-soluble variant of the artemisinin called artesunate, approved as an antimalarial agent, can induce cell death on various cancer cell types. We studied the mechanism of cell death of artesunate on HCT116 colorectal cancer cells.
Eui Tae Kim, Dong-Guk Park
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Regulation of p53 Stability and Function in HCT116 Colon Cancer Cells [PDF]
Journal of Biological Chemistry, 2004 We have used a lentiviral vector to stably express p53 at a physiological level in p53 knockout HCT116 cells. Cells transduced with wild type p53 responded to genotoxic stress by stabilizing p53 and expressing p53 target genes. The reconstituted cells underwent G(1) arrest or apoptosis appropriately depending on the type of stress, albeit less ...
Matthias D, Kaeser +2 more
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NOD2 Expression is Regulated by microRNAs in Colonic Epithelial HCT116 Cells [PDF]
Inflammatory Bowel Diseases, 2014 Crohn's disease (CD) is associated with defective sensing of pathogens in genetically susceptible individuals. Nucleotide-binding oligomerization domain containing 2 (NOD2) mutations in coding regions are strongly linked to CD pathogenesis. Our laboratory has reported that microRNAs (miRNAs) are differentially expressed in CD. However, miRNA regulation
Alice Y, Chuang +4 more
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Frontiers in Pharmacology, 2022 Thymopentin (TP5) is an immunomodulatory pentapeptide that has been widely used in malignancy patients with immunodeficiency due to radiotherapy and chemotherapy.
Peng-Cheng Yu +15 more
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Induction of p53-Dependent Apoptosis by Prostaglandin A2
Biomolecules, 2020 Prostaglandin (PG) A2, one of cyclopentenone PGs, is known to induce activation of apoptosis in various cancer cells. Although PGA2 has been reported to cause activation of apoptosis by altering the expression of apoptosis-related genes, the role of p53,
Su-Been Lee +4 more
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Antioxidants, 2019 Indirubin-3′-monoxime (I3M) exhibits anti-proliferative activity in various cancer cells; however, its anti-cancer mechanism remains incompletely elucidated.
Matharage Gayani Dilshara +7 more
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