Results 11 to 20 of about 4,460,555 (293)
Results in Chemistry, 2022 The Sorafenib tosylate (ST) emulsified drug delivery system (ST-SEDDS) was designed and characterized in response to the poor solubility and bioavailability of ST.
Sankha Bhattacharya +2 more
doaj +1 more source
Induction of DR5-Dependent Apoptosis by PGA2 through ATF4-CHOP Pathway
Molecules, 2022 Prostaglandin (PG) A2, a cyclopentenone PG, induced apoptosis in both HCT116 and HCT116 p53 −/− cells. Although PGA2-induced apoptosis in HCT116 cells was dependent on the p53-DR5 pathway, the mechanism underlying PGA2-induced apoptosis in HCT116 p53 −/−
Kyeong-Min Park +4 more
doaj +1 more source
Procaine Induces Epigenetic Changes in HCT116 Colon Cancer Cells [PDF]
Genetics Research International, 2016 Colon cancer is the third most commonly diagnosed cancer in the world, and it is the major cause of morbidity and mortality throughout the world. The present study aimed at treating colon cancer cell line (HCT116) with different chemotherapeutic drug/drug combinations (procaine, vorinostat “SAHA,” sodium phenylbutyrate, erlotinib, and carboplatin). Two
Hussein Sabit +3 more
openaire +2 more sources
Characterizing oxaliplatin-resistant HCT116 cells.
, 2023 A) Dose-response curves of cell viability in the parental HCT116 cells, HCT116/OX-R4.3, and HCT116/OX-R10 cells treated with various concentrations of oxaliplatin. B) The survival fraction of cells treated with 0.1–60 μM oxaliplatin.
Zarrin Minuchehr (482407) +2 more
core +1 more source
Frontiers in Oncology, 2021 Scaphium affine ethanol extracts (SAE) is a species that has been shown to contain various physiological effects; however, its anticancer effects have yet to be revealed.
Hye Won Kawk +4 more
doaj +1 more source
YM155, specific survivin inhibitor, can enhance artesunate-induced cytotoxicity in HCT116 colon cancer cells [PDF]
Korean Journal of Clinical Oncology, 2020 Purpose A water-soluble variant of the artemisinin called artesunate, approved as an antimalarial agent, can induce cell death on various cancer cell types. We studied the mechanism of cell death of artesunate on HCT116 colorectal cancer cells.
Eui Tae Kim, Dong-Guk Park
doaj +1 more source
NOD2 Expression is Regulated by microRNAs in Colonic Epithelial HCT116 Cells [PDF]
Inflammatory Bowel Diseases, 2014 Crohn's disease (CD) is associated with defective sensing of pathogens in genetically susceptible individuals. Nucleotide-binding oligomerization domain containing 2 (NOD2) mutations in coding regions are strongly linked to CD pathogenesis. Our laboratory has reported that microRNAs (miRNAs) are differentially expressed in CD. However, miRNA regulation
Alice Y, Chuang +4 more
openaire +2 more sources
Regulation of p53 Stability and Function in HCT116 Colon Cancer Cells [PDF]
Journal of Biological Chemistry, 2004 We have used a lentiviral vector to stably express p53 at a physiological level in p53 knockout HCT116 cells. Cells transduced with wild type p53 responded to genotoxic stress by stabilizing p53 and expressing p53 target genes. The reconstituted cells underwent G(1) arrest or apoptosis appropriately depending on the type of stress, albeit less ...
Matthias D, Kaeser +2 more
openaire +2 more sources
Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures [PDF]
, 2014 Objective Treatment of colorectal cancer (CRC) remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU)-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50–60%.
Patricia Kraehe +17 more
core +1 more source
Frontiers in Pharmacology, 2022 Thymopentin (TP5) is an immunomodulatory pentapeptide that has been widely used in malignancy patients with immunodeficiency due to radiotherapy and chemotherapy.
Peng-Cheng Yu +15 more
doaj +1 more source