Results 41 to 50 of about 47,486 (225)

The ganglioside GM3 is associated with cisplatin-induced apoptosis in human colon cancer cells. [PDF]

PLoS ONE, 2014
Cisplatin (cis-diamminedichloroplatinum, CDDP) is a well-known chemotherapeutic agent for the treatment of several cancers. However, the precise mechanism underlying apoptosis of cancer cells induced by CDDP remains unclear.
Tae-Wook Chung, Hee-Jung Choi, Seok-Jo Kim, Choong-Hwan Kwak, Kwon-Ho Song, Un-Ho Jin, Young-Chae Chang, Hyeun Wook Chang, Young-Choon Lee, Ki-Tae Ha, Cheorl-Ho Kim   +10 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Mechanistic study on Tricellulin regulation of colorectal cancer cell invasion, metastasis and epithelial-mesenchymal transition

结直肠肛门外科
[Objectives] To investigate the related molecular mechanisms by which Tricellulin regulates the invasion, migration and metastasis and epithelial-mesenchymal transition (EMT) progression in colorectal cancer. [Methods] Tissue specimens from 40 colorectal
Yang Wenfang, Liao Cun, Zhang Jinxiu, Cheng Ruoxi, Pan Xiaoping, Chen Qiuling, Tan Yanlin, Feng Kaoyan, Qin Mengbin, Huang Jie’an   +9 more
doaj   +1 more source

Coptidis Rhizoma Extract Reverses 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells via Modulation of Thymidylate Synthase

Molecules, 2021
Colorectal cancer (CRC) is a malignancy of the colon or rectum. It is ranked as the third most common cancer in both men and women worldwide. Early resection permitted by early detection is the best treatment, and chemotherapy is another main treatment ...
Yong-Hwi Kang, Jin-Seok Lee, Nam-Hun Lee, Seung-Hyung Kim, Chang-Seob Seo, Chang-Gue Son   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase

Journal of Ginseng Research, 2016
Background: Ginsenoside Rh2 (GRh2) is the main bioactive component in American ginseng, a commonly used herb, and its antitumor activity had been studied in previous studies.
Jianjun Yang, Donghong Yuan, Tongchao Xing, Hongli Su, Shengjun Zhang, Jiansheng Wen, Qiqiang Bai, Dongmei Dang   +7 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Design and synthesis of novel oridonin analogues as potent anticancer agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
To identify anticancer agents with higher potency and lower toxicity, a series of oridonin derivatives with substituted benzene moieties at the C17 position were designed, synthesised, and evaluated for their antiproliferative properties.
Qing-Kun Shen, Zheng-Ai Chen, Hong-Jian Zhang, Jia-Li Li, Chuan-Feng Liu, Guo-Hua Gong, Zhe-Shan Quan   +6 more
doaj   +1 more source

Aberrant ROS Mediate Cell Cycle and Motility in Colorectal Cancer Cells Through an Oncogenic CXCL14 Signaling Pathway

Frontiers in Pharmacology, 2021
Background: Reactive oxygen species (ROS) act as signal mediators to induce tumorigenesis.Objective: This study aims to explore whether chemokine CXCL14 is involved in the proliferation and migration of ROS-induced colorectal cancer (CRC) cells.Methods ...
Jun Zeng, Mei Li, Jun-Yu Xu, Heng Xiao, Xian Yang, Jiao-Xiu Fan, Kang Wu, Kang Wu, Shuang Chen   +8 more
doaj   +1 more source

Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice

Apoptosis, 2007
Labd-14-ene-8, 13-diol (sclareol) is a labdane-type diterpene, which has demonstrated significant cytotoxic activity against human leukemic cell lines, but its effect on solid tumor-derived cells is uknown. Here, we demonstrate that addition of sclareol to cultures of human colon cancer HCT116 cells results in inhibition of DNA synthesis, arrest of ...
Dimas, K., Hatziantoniou, S., Tseleni, S., Khan, H., Georgopoulos, A., Alevizopoulos, K., Wyche, J.H., Pantazis, P., Demetzos, C.   +8 more
openaire   +3 more sources