Results 41 to 50 of about 4,460,555 (293)
Integrative Cancer Therapies, 2021 Doxorubicin (Dox) induces senescence in numerous cancer cell types, but these senescent cancer cells relapse again if they are not eliminated. On this principle, we investigated the apoptotic effect of thymoquinone (TQ), the active ingredient of Nigella ...
Ali H El-Far PhD +6 more
doaj +1 more source
Cellular Uptake of Decitabine by Equilibrative Nucleoside Transporters in HCT116 Cells
Biological & Pharmaceutical Bulletin, 2015 DNA hypermethylation, an epigenetic change that silences gene expression without altering nucleotide sequences, plays a critical role in the formation and progression of colorectal cancers as well as in the acquisition of drug resistance. Decitabine (DAC), a DNA methyltransferase 1 inhibitor of nucleoside analogues, has been shown to restore gene ...
Ueda, Kumiko +2 more
openaire +3 more sources
Role of the transient receptor potential melastatin 4 in inhibition effect of arsenic trioxide on the tumor biological features of colorectal cancer cell [PDF]
PeerJBackground To investigate the effects of arsenic trioxide (ATO) on human colorectal cancer cells (HCT116) growth and the role of transient receptor potential melastatin 4 (TRPM4) channel in this process. Methods The viability of HCT116 cells was assessed
Zhan Gao +9 more
doaj +2 more sources
Lentivirus-mediated NIBP knockdown in HCT116 cells.
, 2017 Control un-transfected HCT116 cells had higher NIBP protein expression compared to NIBP-knockdown HCT116 cells. Cells transfected with an empty vector (NC) had high NIBP expression, similar to the control un-transfected HCT116 cells, as determined by ...
Mengbin Qin (3710482) +6 more
core +1 more source
Disease Models & Mechanisms, 2020 Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured.
Joshua R. Huot +3 more
doaj +1 more source
CD133 Affects the Invasive Ability of HCT116 Cells by Regulating TIMP-2 [PDF]
The American Journal of Pathology, 2013 CD133 is widely expressed in colorectal cancer (CRC) tissues and cell lines. This protein has been used as a marker of CRC cancer stem cells, although the function and mechanism of CD133 in CRC invasion and metastasis remain unclear. In our study, we examined the role of CD133 in CRC invasion in vitro and investigated the mechanism involved in CD133 ...
Min, Zhang +8 more
openaire +2 more sources
, 2013 A, B, Analysis of pH2AX and pChk2 expression and PARP cleavage in HCT116, HCT116+3, and HCT116+3+5 cells treated with 5-FU, SN-38 or oxaliplatin for 48 h and compared to untreated control cells. C, Analysis of caspase-3/7 activity in HCT116, HCT116+3 and
Jae Myung Park (415691) +3 more
core +1 more source
Frontiers in Medicine, 2021 Objective: Surgery is the first line treatment of colorectal cancer (CRC). Anesthetic isoflurane may improve outcomes of cancer surgery. Herein, we investigated the effects of isoflurane on malignant behaviors of CRC cells and its underlying therapeutic ...
Zhe Cai, Liangyuan Suo, Zeqing Huang
doaj +1 more source
Molecules, 2021 Colorectal cancer (CRC) is a malignancy of the colon or rectum. It is ranked as the third most common cancer in both men and women worldwide. Early resection permitted by early detection is the best treatment, and chemotherapy is another main treatment ...
Yong-Hwi Kang +5 more
doaj +1 more source
Cross-regulation of NANOG and OCT4 in HCT116 cancer cells.
, 2013 (A) HCT116 p53+/+ and p53−/− cells were infected with OCT4-GFP-lentivirus. Strong induction of endogenous NANOG expression was found in OCT4-expressing HCT116 p53−/− cells.
Wu Zhang (220174) +11 more
core +1 more source