Results 21 to 30 of about 47,486 (225)
FEBS Open Bio, 2023 5‐Fluorouracil (5‐FU) is widely used for colorectal cancer (CRC) treatment; however, continuous treatment of CRC cells with 5‐FU can result in acquired resistance, and the underlying mechanism of 5‐FU resistance remains unclear. We previously established
Chinatsu Kurasaka +4 more
doaj +1 more source
Investigation of fusion gene expression in HCT116 cells
Oncology Letters, 2017 Colon cancer is the most common type of gastrointestinal cancer. A number of specific and sensitive biomarkers facilitate the diagnosis and monitoring of patients with colon cancer. Fusion genes are typically identified in cancer and a majority of the newly identified fusion genes are oncogenic in nature.
Yanmei, Zhang +3 more
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Entrainment of superoxide rhythm by menadione in HCT116 colon cancer cells [PDF]
Scientific Reports, 2019 AbstractReactive oxygen species (ROS) are primary effectors of cytotoxicity induced by many anti-cancer drugs. Rhythms in the pseudo-steady-state (PSS) levels of particular intracellular ROS in cancer cells and their relevance to drug effectiveness are unknown thus far.
Uma Kizhuveetil +5 more
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Marine Drugs, 2023 Human colorectal cancer (CRC) is a recurrent, deadly malignant tumour with a high incidence. The incidence of CRC is of increasing alarm in highly developed countries, as well as in middle to low-income countries, posing a significant global health ...
Blessing Mabate +3 more
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Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells
International Journal of Molecular Medicine, 2011 Naringenin has been shown to display various biological effects such as antioxidant, anticancer, anti-inflammatory, and antiviral activities. Taxifolin inhibits the production of lipopolysaccharide-induced prostaglandin E, and fustin suppresses the activity of acetylcholinesterase. They all belong to flavanone
Yoonkyung, Woo +5 more
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The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): The study aimed to investigate the effects of resveratrol on colorectal cancer HCT116 cells, including cell viability, apoptosis, and migration, and the partial mechanisms focused on hedgehog/gli-1 signaling pathways. Materials and Methods:
Zhou Du +7 more
doaj +1 more source
The impact of p53 on the early stage replication of retrovirus
Virology Journal, 2017 Background The function of p53 in cancer biology has been studied extensively, but its role in anti-retrovirus infection has been elusive for many years. The restriction of retrovirus early stage replication by p53 was investigated in this study.
Michaela Kinnetz +4 more
doaj +1 more source
Integrative Cancer Therapies, 2023 6-Shogaol from ginger has anti-inflammatory, anti-oxidation and anti-cancer effects. Aim of the Study: To study the effects and possible mechanisms of 6-Shogaol on inhibiting the migration of colon cancer cells Caco2 and HCT116 and prove the effects on ...
Min Chen PhD +6 more
doaj +1 more source
Cells, 2021 Novel target therapy is on the spotlight for effective cancer therapy. Hence, in the present study, the underlying apoptotic mechanism of Morusin was explored in association with miR193a-5p mediated ZNF746/c-Myc signaling axis in colorectal cancer cells (
Woon-Yi Park +7 more
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hTERT-targeted RNA interference inhibits tumorigenicity and motility of HCT116 cells [PDF]
Cancer Biology & Therapy, 2008 Telomerase is proposed as an anticancer target. Increasing evidence suggests that telomerase is involved in functions independent of telomere-extension activity. In this study, we designed a small interfering RNA (siRNA) targeting human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase.
Ying, Shen +4 more
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