Results 61 to 70 of about 4,460,555 (293)
Advanced Science, EarlyView.Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li +8 more
wiley +1 more source
Design and synthesis of novel oridonin analogues as potent anticancer agents
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 To identify anticancer agents with higher potency and lower toxicity, a series of oridonin derivatives with substituted benzene moieties at the C17 position were designed, synthesised, and evaluated for their antiproliferative properties.
Qing-Kun Shen +6 more
doaj +1 more source
PKR regulation by 5-FU treatment in HCT116 p53+/+ and HCT116 p53−/− cells.
, 2013 (A) HCT116 p53+/+, HCT116 p53−/− cells were mock-treated, treated with 500 IU/ml of human IFNα during 16 hours, or treated with 10 µM of 5-FU during 4, 8, 16 and 24 hours.
Jose Carlos Prados (345573) +10 more
core +1 more source
Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer
Advanced Science, EarlyView.The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu +13 more
wiley +1 more source
Journal of Ginseng Research, 2016 Background: Ginsenoside Rh2 (GRh2) is the main bioactive component in American ginseng, a commonly used herb, and its antitumor activity had been studied in previous studies.
Jianjun Yang +7 more
doaj +1 more source
TNFα treatment triggers EMT in HCT116 cells.
, 2013 (A) HCT116 cells were treated with or without TNFα (20 ng/ml) for 4 days. Cell morphological changes associated with EMT are shown in the phase contrast image.
Shao-Hui Cai (335225) +9 more
core +1 more source
Advanced Science, EarlyView.Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang +10 more
wiley +1 more source
ATR inhibition enhances radiosensitivity in p53-deficient colorectal cancer cells
Discover OncologyRadiosensitizers that improve tumor-cell responses to radiation without increasing normal-tissue toxicity are needed in colorectal cancer (CRC).
Na Shen, Rui Zong, Jie Li, Xuemei Liu
doaj +1 more source
Characterization of Troenan-induced calcium signals in HCT116 cells.
, 2017 (A) Representative image of HCT116 cells stimulated with Troenan (300 μM) in calcium imaging analysis. (B) Number of cells responding to Troenan in different concentrations.
Stephan Hahn (534868) +8 more
core +1 more source
CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer
Advanced Science, EarlyView.Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano +10 more
wiley +1 more source