Results 51 to 60 of about 4,460,555 (293)
Advanced Functional Materials, EarlyView.A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam +8 more
wiley +1 more source
MSH3 protein expression in HCT116-derived clones and SW480 cells.
, 2013 A, Western blot analysis of MSH3, MLH1, and tubulin in HCT116, HCT116+3, and HCT116+3+5 cells. B, MSH3 expression is controlled by a Tet-on shRNA system in HCT116+3+5 cells cultured in medium with and without 1 µg/ml doxycycline.
Jae Myung Park (415691) +3 more
core +1 more source
Advanced Materials, EarlyView.Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song +14 more
wiley +1 more source
结直肠肛门外科[Objectives] To investigate the related molecular mechanisms by which Tricellulin regulates the invasion, migration and metastasis and epithelial-mesenchymal transition (EMT) progression in colorectal cancer. [Methods] Tissue specimens from 40 colorectal
Yang Wenfang +9 more
doaj +1 more source
The ganglioside GM3 is associated with cisplatin-induced apoptosis in human colon cancer cells. [PDF]
PLoS ONE, 2014 Cisplatin (cis-diamminedichloroplatinum, CDDP) is a well-known chemotherapeutic agent for the treatment of several cancers. However, the precise mechanism underlying apoptosis of cancer cells induced by CDDP remains unclear.
Tae-Wook Chung +10 more
doaj +1 more source
Apoptosis, 2007 Labd-14-ene-8, 13-diol (sclareol) is a labdane-type diterpene, which has demonstrated significant cytotoxic activity against human leukemic cell lines, but its effect on solid tumor-derived cells is uknown. Here, we demonstrate that addition of sclareol to cultures of human colon cancer HCT116 cells results in inhibition of DNA synthesis, arrest of ...
Dimas, K. +8 more
openaire +3 more sources
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Icariin reduces human colon carcinoma cell growth and metastasis by enhancing p53 activities
Brazilian Journal of Medical and Biological Research, 2018 Icariin has been reported to possess high anticancer activity. Colon carcinoma is one of the leading causes of cancer-related mortality worldwide. Here, the anticancer activity of icariin against HCT116 colon carcinoma cells and the possible underlying ...
Meili Tian, Shuang Yang, Xinpeng Yan
doaj +1 more source
Frontiers in Pharmacology, 2021 Background: Reactive oxygen species (ROS) act as signal mediators to induce tumorigenesis.Objective: This study aims to explore whether chemokine CXCL14 is involved in the proliferation and migration of ROS-induced colorectal cancer (CRC) cells.Methods ...
Jun Zeng +8 more
doaj +1 more source
hTERT-targeted RNA interference inhibits tumorigenicity and motility of HCT116 cells [PDF]
Cancer Biology & Therapy, 2008 Telomerase is proposed as an anticancer target. Increasing evidence suggests that telomerase is involved in functions independent of telomere-extension activity. In this study, we designed a small interfering RNA (siRNA) targeting human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase.
Ying, Shen +4 more
openaire +2 more sources