Results 11 to 20 of about 30,746 (144)

Regulation of lnc-TLCD2-1 on Radiation Sensitivity of Colorectal Cancer and Comprehensive Analysis of Its Mechanism

Frontiers in Oncology, 2021
As is well known that colorectal cancer is the third most common cancer in the world, and radiation treatment plays a vital role in colorectal cancer therapy, but radiation resistance is a significant problem in the treatment of colorectal cancer.
Qifeng Yu, Wei Zhang, Xin Zhou, Wenqi Shen, Chungen Xing, Xiaodong Yang   +5 more
doaj   +1 more source

Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Mutations in the Ras/Raf/MEK/ERK pathway are detected in 50% of colorectal cancer cases and play a crucial role in cancer development and progression.
Shu Gong, Dongsheng Xu, Jialin Zhu, Fangdong Zou, Rui Peng   +4 more
doaj   +1 more source

Hybrid liposomes showing enhanced accumulation in tumors as theranostic agents in the orthotopic graft model mouse of colorectal cancer

Drug Delivery, 2018
Hybrid liposomes (HLs) can be prepared by simply sonicating a mixture of vesicular and micellar molecules in a buffer solution. This study aimed to elucidate the therapeutic effects and ability of HLs to detect (diagnosis) cancer in an orthotopic graft ...
Masaki Okumura, Hideaki Ichihara, Yoko Matsumoto   +2 more
doaj   +1 more source

Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase

Journal of Ginseng Research, 2016
Background: Ginsenoside Rh2 (GRh2) is the main bioactive component in American ginseng, a commonly used herb, and its antitumor activity had been studied in previous studies.
Jianjun Yang, Donghong Yuan, Tongchao Xing, Hongli Su, Shengjun Zhang, Jiansheng Wen, Qiqiang Bai, Dongmei Dang   +7 more
doaj   +1 more source

Discovery of second generation heat shock protein 110 (HSP110) inhibitors for potential treatment of colorectal cancer

European Journal of Medicinal Chemistry Reports, 2023
Heat shock protein 110 (HSP110) is an emerging biological target for development of drug to treat colorectal cancer. In the present study, we designed and synthesized a series of novel small-molecule inhibitors of HSP110 based on previously reported ...
Li Xu, Yuan Wang, Xingrui He, Yuan Gao, Frédéric Lirussi, Yi Zhou, Carmen Garrido, Hang Zhang, Tian Xie, Xiang-Yang Ye   +9 more
doaj   +1 more source

Intra-tumoral heterogeneity in metastatic potential and survival signaling between iso-clonal HCT116 and HCT116b human colon carcinoma cell lines. [PDF]

PLoS ONE, 2013
Colorectal cancer (CRC) metastasis is a leading cause of cancer-related deaths in the United States. The molecular mechanisms underlying this complex, multi-step pathway are yet to be completely elucidated.
Sanjib Chowdhury, Melanie Ongchin, Elizabeth Sharratt, Ivan Dominguez, Jing Wang, Michael G Brattain, Ashwani Rajput   +6 more
doaj   +1 more source

8-Cl-Adenosine-Induced Inhibition of Colorectal Cancer Growth In Vitro and In Vivo

Neoplasia: An International Journal for Oncology Research, 2000
The cAMP analogue 8-Cl-cAMP induces apoptosis and inhibits proliferation of a wide variety of malignancies in vitro and in vivo with relatively little toxicity.
Chris C. Carlson, Rebecca Chinery, Laura L. Burnham, Daniel T. Dransfield   +3 more
doaj   +1 more source

Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer

Marine Drugs, 2017
Background: There is increasing evidence that marine omega-3 oils are involved in the reduction of cancer risk and progression. However, the anticancer effect of omega-3 monoglyceride on colorectal cancer has yet to be assessed.
Caroline Morin, Enrique Rodríguez, Pierre U. Blier, Samuel Fortin   +3 more
doaj   +1 more source

Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin

Open Biology, 2023
Expression and activity of the AMP-activated protein kinase (AMPK) α1 catalytic subunit of the heterotrimeric kinase significantly correlates with poor outcome for colorectal cancer patients.
Kaitlin R. Morrison, Tingting Wang, Kuan Yoow Chan, Eleanor W. Trotter, Ari Gillespie, Michael Z. Michael, Jonathan S. Oakhill, Iain M. Hagan, Janni Petersen   +8 more
doaj   +1 more source

Mechanistic study on Tricellulin regulation of colorectal cancer cell invasion, metastasis and epithelial-mesenchymal transition

结直肠肛门外科
[Objectives] To investigate the related molecular mechanisms by which Tricellulin regulates the invasion, migration and metastasis and epithelial-mesenchymal transition (EMT) progression in colorectal cancer. [Methods] Tissue specimens from 40 colorectal
Yang Wenfang, Liao Cun, Zhang Jinxiu, Cheng Ruoxi, Pan Xiaoping, Chen Qiuling, Tan Yanlin, Feng Kaoyan, Qin Mengbin, Huang Jie’an   +9 more
doaj   +1 more source