Results 11 to 20 of about 3,050,618 (255)

A zebrafish HCT116 xenograft model to predict anandamide outcomes on colorectal cancer

Cell Death & Disease, 2022
AbstractColon cancer is one of the leading causes of death worldwide. In recent years, cannabinoids have been extensively studied for their potential anticancer effects and symptom management. Several in vitro studies reported anandamide’s (AEA) ability to block cancer cell proliferation and migration, but evidence from in vivo studies is still lacking.
Francesca Maradonna, Camilla M. Fontana, Fiorenza Sella, Christian Giommi, Nicola Facchinello, Chiara Rampazzo, Micol Caichiolo, Seyed Hossein Hoseinifar, Luisa Dalla Valle, Hien Van Doan, Oliana Carnevali   +10 more
openaire   +6 more sources

YM155, specific survivin inhibitor, can enhance artesunate-induced cytotoxicity in HCT116 colon cancer cells [PDF]

Korean Journal of Clinical Oncology, 2020
Purpose A water-soluble variant of the artemisinin called artesunate, approved as an antimalarial agent, can induce cell death on various cancer cell types. We studied the mechanism of cell death of artesunate on HCT116 colorectal cancer cells.
Eui Tae Kim, Dong-Guk Park
doaj   +1 more source

MicroRNA-941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer. [PDF]

Ann Gastroenterol Surg
Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Li H, Liu Y, Chen H, Li J, Li X, Chen Y.
europepmc   +2 more sources

Comparative Analyses of Fucoidans from South African Brown Seaweeds That Inhibit Adhesion, Migration, and Long-Term Survival of Colorectal Cancer Cells

Marine Drugs, 2023
Human colorectal cancer (CRC) is a recurrent, deadly malignant tumour with a high incidence. The incidence of CRC is of increasing alarm in highly developed countries, as well as in middle to low-income countries, posing a significant global health ...
Blessing Mabate, Chantal Désirée Daub, Brett Ivan Pletschke, Adrienne Lesley Edkins   +3 more
doaj   +1 more source

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation. [PDF]

Adv Sci (Weinh)
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Chen F, Wang M, Yong H, Ding J, Xu S, Ge Q, Wang Y, Zhang L, Xiao Q, Li B, Lin L, Chu S, Wang Q, Bai J, Hou P.   +14 more
europepmc   +2 more sources

LPS Induces microRNAs -9, -192, and -205 Overexpression in Colorectal Cell Lines SW480, HCT116

Middle East Journal of Cancer, 2020
Background: Today, cancer is one of the serious health issues worldwide. In USA, colorectal cancer is the third cause of death. Reportedly, some risk factors, including family history of colorectal cancer, age, and infectious diseases can deteriorate the
Shaian Tavakolian, Hossein Goudarzi, Ebrahim Faghihloo   +2 more
doaj   +1 more source

Hedyotis diffusa–Sculellaria barbata (HD–SB) suppresses the progression of colorectal cancer cells via the hsa_circ_0039933/hsa-miR-204-5p/wnt11 axis

Scientific Reports, 2023
Our previous study confirmed that the combination of Hedyotis diffusa (HD) and Scutellaria barbata (SB) significantly inhibited colorectal cancer cell proliferation and the WNT signaling pathway.
Danye Zhu, Shanmin Yuan, Cong Chen
doaj   +1 more source

Downregulation of miR-423-5p Contributes to the Radioresistance in Colorectal Cancer Cells

Frontiers in Oncology, 2021
Resistance to radiotherapy is the main reason causing treatment failure in locally advanced rectal cancer. MicroRNAs (miRNAs) have been well demonstrated to regulate cancer development and progression. However, how miRNAs regulate radiotherapy resistance
Yuanyuan Shang, Lingfei Wang, Zhe Zhu, Wei Gao, Dan Li, Zhuqing Zhou, Lin Chen, Chuan-gang Fu   +7 more
doaj   +1 more source

Expression of γ-synuclein in colorectal cancer tissues and its role on colorectal cancer cell line HCT116

World Journal of Gastroenterology, 2009
To investigate the expression pattern of gamma-synuclein in colorectal cancer (CRC) tissues, and to study the effects of gamma-synuclein on CRC cell line HCT116 biological features in vitro.The expression pattern of gamma-synuclein was determined in 54 CRC tissues and 30 tumor-matched nonneoplastic adjacent tissues (NNAT) 5 cm away from the tumor via ...
Qing, Ye, Bo, Feng, Yuan-Fei, Peng, Xue-Hua, Chen, Qu, Cai, Bei-Qin, Yu, Liang-Hui, Li, Ming-Yuan, Qiu, Bing-Ya, Liu, Min-Hua, Zheng   +9 more
openaire   +2 more sources

Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade [PDF]

, 2012
Gelsolin is a cytoskeletal protein which participates in actin filament dynamics and promotes cell motility and plasticity. Although initially regarded as a tumor suppressor, gelsolin expression in certain tumors correlates with poor prognosis and ...
Prem Kumar, Sutherland K Maciver, Manuel Salto-tellez, Celestial T. Yap (142210), Tochhawng, L., Zhuo, J., Celestial T Yap, Maciver, S.K., Koh, Shiuan, K. Maciver, Salto-Tellez Manuel, Manikandan Jayapal (64624), Tan, Ee Hong, Hooi, S., Jayapal, Manikandan, Maciver, Sutherland K., Yaw Chyn Lim (142208), Zhuo Jingli, Lalchhandami Tochhawng (142188), Jingli Zhuo, Ee Hong Tan (142182), Ee Hong Tan, Alan Prem Kumar (142201), Tay Hwee Kee, Lim, Yaw Chyn, Tay, H., Kumar, A.P., Tochhawng, Lalchhandami, Alan Prem Kumar, Maciver, Sutherland K, Ami Tochhawng, Koh, S., Salto-Tellez, M., Hwee Kee Tay (64625), Tay, H.K., Maciver, S., Benedict Yan (142185), Yap Celestial T., Kumar, Alan Prem, Shiuan Koh (142191), Lalchhandami Tochhawng, Lim, Y., Shing Chuan Hooi (50996), Jayapal Manikandan, Goh, Yaw Chong, Shiuan Koh, Tan, E.H., Yap, C., Yap, Celestial T, Yap, Celestial T., Tochhawng Lalchhandami, Tan, E., Lim, Y.C., Hooi, Shing Chuan, An Jayapal, Yan, B., Hwee Kee Tay, Hooi, S.C., Kumar Alan Prem, Sutherland K. Maciver (142194), Tan Ee Hong, Celestial T. Yap, Goh, Y., Manikandan Jayapal, Maciver Sutherland K., Goh Yaw Chong, Jingli Zhuo (142178), Zhuo, Jingli, Yap, C.T., Benedict Yan, Lim Yaw Chyn, Yan, Benedict, Jayapal, M., Yaw Chyn Lim, Goh, Y.C., Salto-Tellez, Manuel, Yaw Chong Goh, Yaw Chong Goh (142205), Koh Shiuan, Yan Benedict, Hooi Shing Chuan, Manuel Salto-Tellez (142198), Tay, Hwee Kee, Shing Chuan Hooi   +83 more
core   +2 more sources