Results 41 to 50 of about 3,050,618 (255)

Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer

Marine Drugs, 2017
Background: There is increasing evidence that marine omega-3 oils are involved in the reduction of cancer risk and progression. However, the anticancer effect of omega-3 monoglyceride on colorectal cancer has yet to be assessed.
Caroline Morin, Enrique Rodríguez, Pierre U. Blier, Samuel Fortin   +3 more
doaj   +1 more source

Knockdown of Slug by RNAi inhibits the proliferation and invasion of HCT116 colorectal cancer cells

Molecular Medicine Reports, 2013
Colorectal cancer is one of the most common alimentary malignancies. Slug has been shown to be an ideal target for cancer gene therapy by numerous studies due to its strong anti‑apoptotic effect. The elevated expression of Slug is a frequent genetic abnormality observed in colorectal cancer.
Jiang, Qian, Hong, Liu, Wangsheng, Chen, Kunming, Wen, Weidong, Lu, Chun, Huang, Zhongxue, Fu   +6 more
openaire   +3 more sources

Thirty-day postoperative mortality after colorectal cancer surgery in England. [PDF]

, 2011
OBJECTIVES: To assess the variation in risk-adjusted 30-day postoperative mortality for patients with colorectal cancer between hospital trusts within the English NHS.
Quirke, Philip, Finan, Paul J, B. Rachet, E. F. Taylor, D. Forman, E. J. A. Morris, P. J. Finan, Thomas, James D, M. P. Coleman, Taylor, Elizabeth F, Forman, David, J. D. Thomas, Coleman, Michel P, P. Quirke, Rachet, Bernard, Morris, Eva JA   +15 more
core   +1 more source

Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin

Open Biology, 2023
Expression and activity of the AMP-activated protein kinase (AMPK) α1 catalytic subunit of the heterotrimeric kinase significantly correlates with poor outcome for colorectal cancer patients.
Kaitlin R. Morrison, Tingting Wang, Kuan Yoow Chan, Eleanor W. Trotter, Ari Gillespie, Michael Z. Michael, Jonathan S. Oakhill, Iain M. Hagan, Janni Petersen   +8 more
doaj   +1 more source

EPHX2 Loss Promotes CRC Migration via EET-Dependent Chemokine Elevation and Mitochondrial Defect. [PDF]

Cancer Sci
Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Zhu J, Chang J, Li Z, Wu J, Yu P, Zheng J, Li L, Tao J, Wu H, Li Y, Liu M.   +10 more
europepmc   +2 more sources

Bevacizumab plus Irinotecan-Based Regimens in the Treatment of Metastatic Colorectal Cancer [PDF]

, 2010
Objectives: Bevacizumab is a monoclonal antibody that directly inhibits vascular endothelial growth factor, a key regulator of angiogenesis. Bevacizumab significantly improves progression-free and/or overall survival in metastatic colorectal cancer in ...
Volker Heinemann, Paulo M. Hoff, Heinemann, Volker, Hoff, Paulo M.   +3 more
core   +1 more source

A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells [PDF]

Food Chemistry, 2011
Phytate, myo-inositol hexaphosphate (IP6), has been shown to possess anti-carcinogenic qualities. IP6 appears to be partially digested in the digestive tract and degraded into inositol di, tri-, and tetra-phosphate (IP2, IP3, and IP4). The present study investigated whether IP3-rich phytate hydrolysate (IP3-RPH), a partially degraded product from ...
Ishizuka, Satoshi, Saitoh, Ken-ichi, Suzuki, Takuya, Lee, Jae-Sung, Hara, Hiroshi   +4 more
openaire   +3 more sources

Anticipated regret to increase uptake of colorectal cancer screening (ARTICS):a randomised controlled trial [PDF]

, 2015
Screening is important for early detection of colorectal cancer. Our aim was to determine whether a simple anticipated regret (AR) intervention could increase uptake of colorectal cancer screening. A randomised controlled trial of a simple, questionnaire-
Brownlee, Linda A., Steele, Robert J. C., O'Carroll, Ronan E., Steele, Robert, Chambers, Julie A., Chambers, Julie, Brownlee, Linda, Libby, Gillian, Steele, Robert J.C., O'Carroll, Ronan   +9 more
core   +1 more source

The global, regional, and national burden of colorectal cancer in 204 countries and territories from 1990 to 2019

, 2022
Background. Colorectal cancer is the third leading cause of cancer deaths worldwide. Given the recent increasing trends in colorectal cancer incidence globally, up-to-date information on the colorectal cancer burden could guide screening, early detection,

core   +1 more source

Mechanistic study on Tricellulin regulation of colorectal cancer cell invasion, metastasis and epithelial-mesenchymal transition

结直肠肛门外科
[Objectives] To investigate the related molecular mechanisms by which Tricellulin regulates the invasion, migration and metastasis and epithelial-mesenchymal transition (EMT) progression in colorectal cancer. [Methods] Tissue specimens from 40 colorectal
Yang Wenfang, Liao Cun, Zhang Jinxiu, Cheng Ruoxi, Pan Xiaoping, Chen Qiuling, Tan Yanlin, Feng Kaoyan, Qin Mengbin, Huang Jie’an   +9 more
doaj   +1 more source