Results 61 to 70 of about 3,050,618 (255)

Evaluation of the accuracy of serum MMP-9 as a test for colorectal cancer in a primary care population [PDF]

, 2006
Background Bowel cancer is common and is a major cause of death. Meta-analysis of randomised controlled trials estimates that screening for colorectal cancer using faecal occult blood (FOB) test reduces mortality from colorectal cancer by 16%.
Redman, VD, Michael JO Wakelam, Colbourne, L, Janet A Dunn, Val D Redman, Lynne Colbourne, Dunn, Janet, Martin, A, Martin Ashley, Wilson, S, Wakelam, Michael, Ismail, T, Hobbs Richard FD, Wakelam, Michael J.O., Sue Wilson, Hobbs, RFD, Martin, Ashley, Wilson, Sue, Dr, Redman, Valerie, Colbourne Lynne, Wakelam, MJ, Redman, Val. D., Colbourne, Lynne, Ryan, Angela V., Wilson Sue, Angela V Ryan, Ryan, AV, Tariq Ismail, Fiona Patrick, Ashley Martin, Richard FD Hobbs, Ryan Angela V, Patrick, Fiona, Patrick, F, Ismail, Tariq, Ismail Tariq, Dunn, Janet A., Wilson, Sue, Redman Val D, Ryan, Angela, Dunn Janet A, Wakelam, MJO, Hobbs, RF, Dunn, JA, Hobbs, Richard F. D., Patrick Fiona, Wakelam Michael JO   +46 more
core   +2 more sources

Discovery of highly potent and selective 7-ethyl-10-hydroxycamptothecin-glucose conjugates as potential anti-colorectal cancer agents

Frontiers in Pharmacology, 2022
7-Ethyl-10-hydroxycamptothecin (SN38), a highly potent metabolite of irinotecan, has an anticancer efficacy 100–1000 folds more than irinotecan in vitro. However, the clinical application of SN38 has been limited due to the very narrow therapeutic window
Chao Yang, Chao Yang, Chao Yang, An-Jie Xia, Cheng-Hao Du, Ming-Xing Hu, You-Ling Gong, Rong Tian, Xin Jiang, Yong-Mei Xie   +9 more
doaj   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer [PDF]

, 2009
<b>Background</b>: A pronounced tumour inflammatory infiltrate is known to confer a good outcome in colorectal cancer. Klintrup and colleagues reported a structured assessment of the inflammatory reaction at the invasive margin scoring low ...
Roxburgh, C.S., McMillan, D.C., Horgan, P.G., Salmond, J.M., Oien, K.A.   +4 more
core   +1 more source

Chemical Synthesis of the PAX Protein Inhibitor EG1 and Its Ability to Slow the Growth of Human Colorectal Carcinoma Cells

Frontiers in Oncology, 2021
Colorectal cancer is primarily a disease of the developed world. The incidence rate has continued to increase over time, reflecting both demographic and lifestyle changes, which have resulted in genomic and epigenomic modifications.
Lorissa McDougall, Jui Thiang Brian Kueh, Jake Ward, Joel D. A. Tyndall, Joel D. A. Tyndall, Adele G. Woolley, Adele G. Woolley, Adele G. Woolley, Sunali Mehta, Sunali Mehta, Sunali Mehta, Cherie Stayner, David S. Larsen, Michael R. Eccles, Michael R. Eccles, Michael R. Eccles   +15 more
doaj   +1 more source

The Pro-Apoptotic Effects of Curcumin on HCT116 Colorectal Cancer Cells

Midwestern Journal of Undergraduate Sciences
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide, often originating from benign polyps in the colon and rectum that may become malignant if left untreated. While current treatments such as surgery, chemotherapy, and radiation are effective, they often come with severe side effects that impact patient quality of ...
Kuljeet Kaur, Sonia Thomas, Melissa Daggett, J.F. Treml   +3 more
openaire   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Artemether as a modulator of EMT in colorectal cancer: enhancing radiosensitivity and reversing chemo-radiation resistance

BMC Gastroenterology
Background The efficacy of conventional chemoradiotherapy for colorectal cancer is often limited by resistance, with epithelial-mesenchymal transition being a key mechanism.
Lv Ge, Shan Liu, Shenglan Yu, Ming Li, Wanni Zhang, Chunmao Xie, Zhuo Gao, Sijia Tang, Minqi Xiao, Tao Zou, Yongxin Jiang, Hu Lu   +11 more
doaj   +1 more source

γ-Tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells [PDF]

Journal of Cell Science, 2009
Cancer cells frequently induce aberrant centrosomes, which have been implicated in cancer initiation and progression. Human colorectal cancer cells, HCT116, contain aberrant centrioles composed of disorganized cylindrical microtubules and displaced appendages.
Kuriyama, R., Bettencourt-Dias, M., Hoffmann, I., Arnold, M., Sandvig, L.   +4 more
openaire   +3 more sources

Dihydrotanshinone I Inhibits the Proliferation and Growth of Oxaliplatin-Resistant Human HCT116 Colorectal Cancer Cells

Molecules, 2022
Oxaliplatin (OXA) is a first-line chemotherapeutic drug for the treatment of colorectal cancer (CRC), but acquired drug resistance becomes the main cause of treatment failure. Increasing evidence has shown that some natural components may serve as chemoresistant sensitizers.
Wang, Mengge, Xiang, Yusen, Wang, Ruyu, Zhang, Lijun, Zhang, Hong, Chen, Hongzhuan, Luan, Xin, Chen, Lili   +7 more
openaire   +3 more sources