Results 71 to 80 of about 3,050,618 (255)

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Family history of colorectal cancer: a determinant of advanced adenoma stage or adenoma multiplicity?

, 2009
A family history of colorectal cancer may increase colorectal cancer risk by influencing adenoma growth or enhancing the formation of new lesions. Data of men from the prospective Health Professionals Follow-Up Study who underwent an endoscopy between ...
Wu, Kana, Kana Wu, Pieter van 't Veer, Wark, P.A., Charles F. Fuchs, Veer, P., van 't, Fuchs, C.F., Fuchs, Charles F, van 't Veer, P., Fuchs, Charles F., Wu, K., Giovannucci, Edward L., Wark, Petra A, Petra A. Wark, Giovannucci, Edward L, Wark, Petra A.; id_orcid, Edward L. Giovannucci, Giovannucci, E.L., van 't Veer, Pieter   +18 more
core   +1 more source

A cohort study of the recovery of health and wellbeing following colorectal cancer (CREW study): protocol paper [PDF]

, 2012
Background: the number of people surviving colorectal cancer has doubled in recent years. While much of the literature suggests that most people return to near pre-diagnosis status following surgery for colorectal cancer, this literature has largely ...
Foster, Claire L., Fenlon Deborah, Corner Jessica, Jessica Corner, Winter Jane, Smith, Peter, Corner, Jessica L, Richardson Alison, Smith Peter, Deborah Fenlon, Alison Richardson, Jane Winter, Winter, Jane, Foster Claire, Claire Foster, Fenlon, Deborah R., Addington-Hall, Julia M., Addington-Hall Julia, Richardson, Alison, Julia Addington-Hall, Peter Smith   +20 more
core   +2 more sources

Growth inhibition and apoptosis in colorectal cancer cells induced by Vitamin D-Nanoemulsion (NVD): involvement of Wnt/β-catenin and other signal transduction pathways

Cell & Bioscience, 2019
Background More than the two decades, the question of whether vitamin D has a role in cancer frequency, development, and death has been premeditated in detail.
Suhail Razak, Tayyaba Afsar, Ali Almajwal, Iftikhar Alam, Sarwat Jahan   +4 more
doaj   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH

, 2002
Background & Aims: MUTYH-associated polyposis (MAP) is an autosomal recessive disorder caused by mutations in the MUTYH gene. Patients with MAP are at extremely high risk of colorectal cancer, but the risks of colorectal and other cancers in ...
Jones, Natalie, Maher, Eamonn, Sampson, Julian Roy, Edwards, Emma, Christian, Daria, Evans, D Gareth, Vasen, Hans F., Wark, Petra A., Sampson, Julian R, Eccles, Diana, Aretz, Stefan, Nielsen, Maartje, Maher, Eamonn R., Wark, Petra A, Vogt, Stefanie, Wark, Petra A.; id_orcid, Hes, Frederik J, Hes, Frederik J., Evans, D. Gareth, Sampson, Julian R., Vasen, Hans F, Maher, Eamonn R   +21 more
core   +1 more source

Population screening for colorectal cancer means getting FIT:the past, present, and future of colorectal cancer screening using the fecal immunochemical test for hemoglobin (FIT) [PDF]

, 2014
Fecal immunochemical tests for hemoglobin (FIT) are changing the manner in which colorectal cancer (CRC) is screened. Although these tests are being performed worldwide, why is this test different from its predecessors?
Halloran, SP, Fraser, Callum G., Fraser, CG, Young, Graeme P., Halloran, Stephen P., Allison, JE, Allison, James E., Young, GP   +7 more
core   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells [PDF]

, 2013
Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP).
Yong J. Lee, Yong J. Lee (297943), Song, X, Lee, YJ, Seog-Young Kim, Song Xinxin, Xinxin Song, Kim Seog-Young, Yong J Lee, Xinxin Song (297942), Song, Xinxin, Lee Yong J., Kim, Seog-Young, Seog-Young Kim (297940), Kim, SY, Calogero, Raffaele A, Lee, Yong J.   +16 more
core   +2 more sources

Genetic variants in the calcium signaling pathway participate in the pathogenesis of colorectal cancer through the tumor microenvironment

Frontiers in Oncology, 2023
BackgroundCancer risk is influenced by calcium signaling in intracellular and intercellular signaling pathways. However, the relationship between the calcium signaling pathway and colorectal cancer risk remains unknown.
Jing-Yu Wu, Yu Shao, Chang-Zhi Huang, Zhen-Ling Wang, Hong-Qiang Zhang, Zan Fu   +5 more
doaj   +1 more source