Results 91 to 100 of about 33,936 (220)

Taxifolin, a natural flavonoid interacts with cell cycle regulators causes cell cycle arrest and causes tumor regression by activating Wnt/ β -catenin signaling pathway

BMC Cancer, 2018
Background New approaches for the prevention of colon cancer perseveres an essential necessity. Though, resistance to existing chemo-preventive drugs is moderately predominant in colon carcinogenesis.
Suhail Razak, Tayyaba Afsar, Asad Ullah, Ali Almajwal, Musaed Alkholief, Aws Alshamsan, Sarwat Jahan   +6 more
doaj   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

γ-Tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells [PDF]

Journal of Cell Science, 2009
Cancer cells frequently induce aberrant centrosomes, which have been implicated in cancer initiation and progression. Human colorectal cancer cells, HCT116, contain aberrant centrioles composed of disorganized cylindrical microtubules and displaced appendages.
Kuriyama, R., Bettencourt-Dias, M., Hoffmann, I., Arnold, M., Sandvig, L.   +4 more
openaire   +3 more sources

c‐Met‐Targeted Imaging Agents: Progress and Challenges

iRADIOLOGY, EarlyView.
This review summarizes recent advances in c‐Met‐targeted imaging probes, including hepatocyte growth factor (HGF) ligands, antibodies, peptides, and small molecules across magnetic resonance imaging (MRI), positron emission tomography (PET), single‐photon emission computed tomography (SPECT), and optical imaging modalities.
Yonghao Li, Aiyan Ji, Qihang Ding, Hongyue Lou, Zhen Cheng   +4 more
wiley   +1 more source

Differential microRNA expression profiles in HCT116 colorectal cancer cell lines located in the lung and colon

Molecular Medicine Reports, 2014
Colorectal cancer (CRC) is one of the most common types of cancer worldwide. The majority of mortalities caused by colorectal cancer are due to metastatic disease. As numerous CRC patients experience metastasis to the liver or lung and fail to respond to curative therapies, intensive research efforts have sought to identify the molecular changes or ...
Xiao-Hong, Wang, Xin-Min, Yu, Hong, Jiang, Cong, Luo   +3 more
openaire   +3 more sources

Enzyme-catalyzed synthesis of selenium-doped manganese phosphate for synergistic therapy of drug-resistant colorectal cancer

Journal of Nanobiotechnology, 2023
Background The development of multidrug resistance (MDR) during postoperative chemotherapy for colorectal cancer substantially reduces therapeutic efficacy.
Manman Pei, Kaiyuan Liu, Xiao Qu, Kairuo Wang, Qian Chen, Yuanyuan Zhang, Xinyue Wang, Zheng Wang, Xinyao Li, Feng Chen, Huanlong Qin, Yang Zhang   +11 more
doaj   +1 more source

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

Inhibiting CD164 expression in colon cancer cell line HCT116 leads to reduced cancer cell proliferation, mobility, and metastasis in vitro and in vivo

, 2012
Background: CD164 (Endolyn) is a sialomucin, which has been found to play roles in regulating proliferation, adhesion, and differentiation of hematopoietic stem cells. Possible association of CD164 with solid cancer development remains unknown.
Xiang, J, Zhou, G, Zhang, L, Li, G, Yu, F, She, X, Tang, J   +6 more
core   +1 more source

Antiproliferative and Apoptotic Activity of Chamaecyparis obtusa Leaf Extract against the HCT116 Human Colorectal Cancer Cell Line and Investigation of the Bioactive Compound by Gas Chromatography-Mass Spectrometry-Based Metabolomics

Molecules, 2015
Chamaecyparis obtusa (CO) belongs to the Cupressaceae family, and it is found widely distributed in Japan and Korea. In this study, the anti-proliferative activities of the methanol and water extracts of CO leaves against a human colorectal cancer cell ...
Hye-Youn Kim, Seul-Gi Lee, Taek-Joo Oh, Sa Rang Lim, So-Hyun Kim, Hong Jin Lee, Young-Suk Kim, Hyung-Kyoon Choi   +7 more
doaj   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source