Results 111 to 120 of about 33,936 (220)

NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT

Oncology Letters, 2019
Neural precursor cell-expressed, developmentally-downregulated 9 (NEDD9) is a multi-domain skeleton protein that serves an important role in the cell signaling process via modulating invasion, metastasis, proliferation and apoptosis of tumor cells.
Meng, Haining, Wu, Junyu, Huang, Qiao, Yang, Xi, Yang, Kunao, Qiu, Yuexin, Ren, Jiwen, Shen, Ruowu, Qi, Hong   +8 more
openaire   +3 more sources

Aspartate Transporter SLC1A3 Promotes Colorectal Cancer via MDM2‐p53 Pathway and M2 Macrophage Polarization

Cancer Science, EarlyView.
SLC1A3 promotes colorectal cancer progression by transporting extracellular aspartate into tumor cells, thereby activating the PKC/MDM2/p53 pathway to enhance proliferation. Reduced extracellular aspartate, combined with p53‐dependent suppression of CSF2 and IL17C, drives M2 macrophage polarization via immune modulation, macrophage recruitment, and M2 ...
Chao Deng, You Zhou, Sijie Song, Hongtao Liu, Siqi Liao, Li Zhou, Siyuan Chen, Zhihang Zhou, Song He, Bingrong Liu   +9 more
wiley   +1 more source

JNK signaling pathway is involved in piperlongumine-mediated apoptosis in human colorectal cancer HCT116 cells

Oncology Letters, 2015
Piperlongumine (PPLGM), an alkaloid isolated from the long pepper (Piper longum L.), can selectively trigger cancer cell death in colorectal cancer cells. The present study investigated whether the c-Jun NH2-terminal kinase (JNK) signaling pathway is involved in PPLGM-induced apoptosis in the human colorectal cancer HCT116 cell line.
Wen, Li, Chuangyu, Wen, Haiyan, Bai, Xiaoyan, Wang, Xiaoli, Zhang, Lanlan, Huang, Xiangling, Yang, Aikichi, Iwamoto, Huanliang, Liu   +8 more
openaire   +3 more sources

Identification of proteins containing SDMA and ADMA in whole cell extracts of the human colorectal cancer HCT116 cell line, human cervical cancer HeLa cell line, and human non-small cell lung cancer H460 cell line.

, 2023
Identification of proteins containing SDMA and ADMA in whole cell extracts of the human colorectal cancer HCT116 cell line, human cervical cancer HeLa cell line, and human non-small cell lung cancer H460 cell line.
Steven G. Clarke (128898), Yusuke Aoki (15167726), Yutaro Kubota (610244), Robert M. Hoffman (302618), Ashley G. Holtz (17697007), Troy L. Lowe (15810637)   +5 more
core   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Effects of gelam (Melaleuca sp.) honey on apoptosis pathway of colorectal cancer cell lines (HCT116) / Nurul Farah Hana Mohd Adnan [PDF]

, 2012
Honey is reported to contain various compounds such as phenols, vitamins and antioxidants. The present study investigates the anticancer potential of Gelam honey in colorectal cancer cell lines (HCT116).
Mohd Adnan, Nurul Farah Hana
core  

Globo‐H diagnostic stratification and identification of DUSP14 as a candidate target in colorectal cancer

International Journal of Cancer, Volume 159, Issue 4, Page 936-950, 15 August 2026.
What's new? Colorectal cancer (CRC) is increasingly complicated by drug‐resistant tumors that limit the effectiveness of anticancer therapies. Because resistance mechanisms vary among patients and can evolve over time, personalized treatment strategies are needed.
Keren Zohar, Marco Strecker, Thomas Wartmann, Wenjie Shi, Frederike Stelter, Maximilian Doelling, Mihailo Andric, Or Kakhlon, Christian Täger, Denny Schanze, Michael Linnebacher, Michael Naumann, Daniel E. Stange, Dörthe Jechorek, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Dietary Polyphenols as Natural Modulators of NF‐κB Signaling in Inflammation‐Driven Non‐Communicable Diseases: Focus on Cancer

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Dietary polyphenols and phytochemicals suppress NF‐κB signaling. Mechanistically, by inhibiting IκBα degradation and preventing nuclear translocation of p65/p50 complexes, the polyphenols reduce the expression of pro‐inflammatory and pro‐survival genes, thereby decreasing overall cancer cell survival.
Khuzin Dinislam, Anas Shamsi, Syed Tasqeruddin, Moyad Shahwan   +3 more
wiley   +1 more source

Erratum: [Corrigendum] Effects of histone deacetylase inhibitors on ATP‑binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells. [PDF]

Oncol Lett, 2023
Wang H, Chi CH, Zhang Y, Shi B, Jia R, Wang BJ.   +5 more
europepmc   +1 more source

In Vitro Antineoplastic Effects of Zataria multiflora: A Systematic Review of Mechanisms, Selectivity, and Synergy

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Zataria multiflora (ZM) is an aromatic plant containing various bioactive components, including phenolic compounds, flavonoids, and terpenoids. Here, we systematically review 27 articles to explore the effect of ZM on different cancer/normal cell lines.
Alireza Khanahmad, Fatemeh Peymaninezhad, Fariba Sharififar, Ali Sadatmoosavi, Ali Bazi, Roohollah Mirzaee Khalilabadi, Hajar Mardani Valandani   +6 more
wiley   +1 more source