MicroRNA Profiling of Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells [PDF]
Oncomedicine, 2017 Bustamin Kosmo +9 more
openaire +1 more source
Phenotypic profiling of small molecules using cell painting assay in HCT116 colorectal cancer cells
PLOS OneUnderstanding how small molecules affect cellular morphology is essential for exploring their mechanisms of action (MoA) and identifying new therapeutic candidates. In this study, the Cell Painting Assay (CPA) was used to profile 196 small molecules in HCT116 colorectal cancer cells.
Velemir Lavrinenko +5 more
openaire +2 more sources
Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security
Journal of the Science of Food and Agriculture, EarlyView.Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori +9 more
wiley +1 more source
Sex differences in hospital readmission among colorectal cancer patients. [PDF]
, 2005 Background: While several studies have analysed sex and socioeconomic differences in cancer incidence and mortality, sex differences in oncological health care have been seldom considered.
Peris, Mercè +7 more
core +1 more source
Morusin inhibits the growth of human colorectal cancer HCT116‑derived sphere‑forming cells via the inactivation of Akt pathway. [PDF]
Int J Mol Med, 2021 Zhou Y, Li X, Ye M.
europepmc +1 more source
The Journal of Pathology, EarlyView.Abstract The progression of colorectal cancer (CRC) is critically regulated by cancer‐associated fibroblasts (CAFs) within the tumor microenvironment (TME), yet the specific molecular mechanisms by which CAFs influence CRC remain unclear. This study reveals the mechanism by which CAFs promote CRC malignant progression and immune suppression through ...
Huachi Li +6 more
wiley +1 more source
Id4 Suppresses the Growth and Invasion of Colorectal Cancer HCT116 Cells through CK18-Related Inhibition of AKT and EMT Signaling. [PDF]
J Oncol, 2021 Chen HJ +7 more
europepmc +1 more source
Phytotherapy Research, EarlyView.Schisandrin C: A Dual Anti‐Colorectal Cancer Strategy Targeting PPARγ. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer mortality, necessitating novel therapeutic strategies. Schisandrin C (SinC), a bioactive lignan from Schisandra chinensis, exhibits diverse pharmacological activities, but its anti‐CRC mechanisms are poorly ...
Xiao Wei +4 more
wiley +1 more source
Harnessing the Folding of Antitumor Peptides for Controlled Carrier‐Free Drug Delivery
Small, EarlyView.A disulfide‐bridged stapled p53 α‐helix co‐assembled with doxorubicin into protease‐resistant nanocomplexes. Reductive intracellular conditions induced helix refolding and nanostructure disassembly, which enabled the coordinated release of the chemotherapeutic agent and anticancer peptide.
Jae Yun Lee +9 more
wiley +1 more source
Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments
Smart Molecules, EarlyView.Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu +7 more
wiley +1 more source