Results 131 to 140 of about 33,936 (220)

Overexpression of OATP1B3 confers apoptotic resistance in colon cancer

, 2008
Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is normally expressed in hepatocytes. In this study, we demonstrated frequent overexpression of OATP1B3 in colorectal adenocarcinomas. Quantitative RT-PCR analysis of 17 colon tumors indicated
Zaika, Alex, Harris, Elizabeth I, Lee, Wooin, Washington, M. Kay, El-Rifai, Wael, Kim, Richard B., Belkhiri, Abbes, Harris, Elizabeth I., Brunt, Elizabeth M, Kim, Richard B, Lockhart, A. Craig, Glaeser, Hartmut, Brunt, Elizabeth M., Merchant, Nipun   +13 more
core   +1 more source

MiR-3664-3p through suppressing ABCG2, CYP3A4, MCL1, and MLH1 increases the sensitivity of colorectal cancer cells to irinotecan

Heliyon
Background: Colorectal cancer (CRC) is the third most frequently diagnosed malignancy worldwide. Currently, irinotecan (CPT-11) is used alone or in combination with other drugs to treat patients with advanced CRC.
Elham Farrokhnazar, Sahar Moghbelinejad, Reza Najafipour, Ladan Teimoori-Toolabi   +3 more
doaj   +1 more source

Synthesis of spiro[cyclopropane-isatin] derivatives and their therapeutic potential as anticancer agents against colorectal carcinoma

Results in Chemistry
We have designed and synthesized a novel series of spiro[cyclopropane-isatin] derivatives and studied cytotoxic effects of these compounds for colorectal cancer cells (HCT116), with minimal cytotoxicity towards normal cell lines (HEK).
Shashikala Mariswamy Rajesh, Byresh Gowda, Sudhanva M. Srinivasa, Toreshettahally R. Swaroop, Rajaghatta N. Suresh, Veeresha Gowda Shalini, Habbanakuppe D. Preetham, R. Shobith, Kanchugarakoppal S. Rangappa   +8 more
doaj   +1 more source

The mir-199b-5p encapsulated in adipocyte-derived exosomes mediates radioresistance of colorectal cancer cells by targeting JAG1

Heliyon
Radiotherapy is a key treatment option for colorectal cancer, but its efficacy varies among patients. Our previous studies suggested that adipose tissue may confer the radioresistance of several abdominal tumors, such as pancreatic cancer, biliary cancer,
Xiaoli Lv, Zhenyan Li, Yunpeng Dai, Yuji Xiao, Fangrong Shen, Jian Wang, Jianping Cao, Lili Wang, Qiliang Peng, Yang Jiao   +9 more
doaj   +1 more source

Supervillin‐Mediated ZO‐1 Downregulation Facilitates Migration of Cisplatin‐Resistant HCT116 Colorectal Cancer Cells

Journal of Cellular Biochemistry
ABSTRACTSupervillin (SVIL), the biggest member of the villin/gelsolin superfamily, has recently been reported to promote the metastasis of hepatocellular carcinoma by stimulating epithelial‐mesenchymal transition (EMT). However, little is known about the roles of SVIL in the migration of colorectal cancer cells.
Yali Hong, Xu Li, Rongchen Mao, Feier Zhou, Shengnan Li, Chao Zhu, Lai Jin   +6 more
openaire   +2 more sources

TP53 and let-7a micro-RNA regulate K-Ras activity in HCT116 colorectal cancer cells.

, 2013
Recent reports have indicated that KRAS and TP53 mutations predict response to therapy in colorectal cancer. However, little is known about the relationship between these two common genetic alterations.
Joseph Kim, Marjun Duldulao, Carrie Luu, Marwan Fakih, Eileen L Heinrich, Amanda K Arrington, Julio Garcia-Aguilar   +6 more
core   +1 more source

Long Noncoding RNA RP11-278A23.1, a Potential Modulator of p53 Tumor Suppression, Contributes to Colorectal Cancer Progression

Recently, many studies revealed that long noncoding RNAs (lncRNAs) play important roles in cancers. To identify lncRNAs contributing to colorectal cancers, we screened lncRNAs through expression and survival analyses in datasets from The Cancer Genome ...
Masayo Kamikokura, Hiroshi Nakase, Shoichiro Tange, Takashi Tokino, Masashi Idogawa   +4 more
core   +1 more source

Correction to “[NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB‐STAT3 signalling in a non‐m5C manner]”

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
wiley   +1 more source

6,7-Dihydroxy-2-(4′-hydroxyphenyl)naphthalene induces HCT116 cell apoptosis through activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway

, 2019
Ching-Feng Chiu,1–3 Guan-Ying Lai,4 Chung-Hwan Chen,5–7 Chien-Chao Chiu,8 Shao-Wen Hung,8,9 Chi-Fen Chang10 1Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan; 2TMU ...
Chiu CF, Chang CF, Lai GY, Chiu CC, Hung SW, Chen CH   +5 more
core  

Investigating the disease-promoting abilities of gut bacteria in colorectal tumour cells

Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer-related death. The global burden of CRC is rising, particularly in younger populations.
Robson, James
core