Results 151 to 160 of about 3,050,618 (255)
Current Issues in Molecular BiologyAn undescribed seco-kaurane diterpenoid, benincaside A (BA), was isolated from the seeds of Benincasa hispida. The seeds of B. hispida have been traditionally used in folk medicine and previous studies have reported anti-tumor potential in B.
Jai-Sing Yang +4 more
doaj +1 more source
Exploring the Anticancer Potential of Schiff Base Complexes: A Mini‐Review
ChemMedChem, Volume 21, Issue 17, 14 September 2026.Schiff base metal complexes as promising anticancer agents: highlighting DNA interactions, cytotoxicity, molecular targets, and mechanisms of cancer cell death. Schiff bases are well known for their ability to form stable coordination compounds with several transition metals, making them valuable for medicinal chemistry purposes.
Atif Ahmad +4 more
wiley +1 more source
HeliyonBackground: Colorectal cancer (CRC) is the third most frequently diagnosed malignancy worldwide. Currently, irinotecan (CPT-11) is used alone or in combination with other drugs to treat patients with advanced CRC.
Elham Farrokhnazar +3 more
doaj +1 more source
Inositol pyrophosphate kinases in health and disease
FEBS Letters, Volume 600, Issue 17, Page 2379-2396, September 2026.In mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Changchang Xing +6 more
wiley +1 more source
Lamin A/C as a prognostic biomarker in colorectal cancer [PDF]
, 2007 Lamins A and C (A-type lamins) are type V nuclear intermediate filament proteins which form a complex meshwork underlining the inner nuclear membrane termed the nuclear lamina.
Cox, Thomas Robert
core
Advanced Functional Materials, Volume 36, Issue 73, 10 September 2026.A bio‐inspired biopolymeric implantable drug delivery platform enables localized and sustained release of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38) in solid tumor treatment. The three‐dimensional (3D) structured crosslinked‐chitosan implants are fabricated via 3D‐printed molds and provide drug release over 3 months, significantly inhibiting tumor growth ...
Mercedes Lozano‐Garcia +12 more
wiley +1 more source
Results in ChemistryWe have designed and synthesized a novel series of spiro[cyclopropane-isatin] derivatives and studied cytotoxic effects of these compounds for colorectal cancer cells (HCT116), with minimal cytotoxicity towards normal cell lines (HEK).
Shashikala Mariswamy Rajesh +8 more
doaj +1 more source
Journal of Cellular BiochemistryABSTRACTSupervillin (SVIL), the biggest member of the villin/gelsolin superfamily, has recently been reported to promote the metastasis of hepatocellular carcinoma by stimulating epithelial‐mesenchymal transition (EMT). However, little is known about the roles of SVIL in the migration of colorectal cancer cells.
Yali Hong +6 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 51, 14 September 2026.Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye +9 more
wiley +1 more source
Versatile Detection of Cellular Protein via Fluorescence Anisotropy
Advanced Science, Volume 13, Issue 51, 14 September 2026.Cell Lysate Fluorescence Anisotropy (CFAST) utilizes long lifetime dye‐labeled nanobodies for rapid protein quantification in minimally purified, complex cell lysate. When coupled with cellular thermal shift, CFAST allows high‐throughput detection of endogenous protein‐small molecule engagement, facilitating the discovery of novel binders for ...
Qing Tang +12 more
wiley +1 more source