Results 171 to 180 of about 3,050,618 (255)
Picropodophyllin, an IGF‑1 receptor inhibitor, enhances oxaliplatin efficacy in chemoresistant colorectal cancer HCT116 cells by reducing metastatic potential. [PDF]
Oncol LettKayacik N +4 more
europepmc +1 more source
MedComm, Volume 7, Issue 9, September 2026.This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng +9 more
wiley +1 more source
UBE2D4 Upregulation Promotes Cuproptosis Sensitivity in Colorectal Cancer
Molecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.UBE2D4 is genetically upregulated in colorectal cancer and its expression status modulates copper‐induced cuproptosis sensitivity. Copper overload induces UBE2D4 and DLAT expression; UBE2D4 knockdown attenuates DLAT induction and rescues cell viability, suggesting UBE2D4 as a genetic determinant of cuproptosis sensitivity and a potential stratification
Biaoyu Wang +3 more
wiley +1 more source
New Zealand Journal of Botany, Volume 64, Issue 3, September 2026.Introduction: Cardiotoxicity is an undesirable side effect of chemotherapy that limits the effectiveness of cancer treatment. Almost all cardiotoxic agents cause cardiovascular complications, leading to oxidative stress and other pathological conditions.
Susanna Badalyan +2 more
wiley +1 more source
Cranberry Pomace Valorization: Composition, Extraction, Bioactivity, and Food Applications
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.ABSTRACT Cranberry pomace, the principal solid residue generated during cranberry processing, is increasingly recognized as a compositionally valuable coproduct rather than a waste material. This is particularly relevant in North America, where cranberry production is concentrated in the United States and Canada, the two leading producing countries ...
Ali Ali Redha, Tuba Esatbeyoglu
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 18, Page 5516-5540, September 2026.Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn +11 more
wiley +1 more source
SFRP2 Potentiates Metastasis of Colon Cancer by Enhancing Snai1 Protein Stability via USP11
Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.ABSTRACT Metastatic colon cancer remains a significant clinical challenge, often associated with poor patient prognosis. Recent studies have identified the secreted frizzled‐related protein 2 (SFRP2) as a key player in this malignancy, showing its overexpression in metastatic cases.
Yanshen Kuang +6 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Four series of 20 (het)aryl substituted 7‐deazapurine nucleobases were synthesized. Several potent antagonists of all four subtypes of adenosine receptors were identified by functional assay. High‐throughput screening of the IMTM compound library for modulatory activity on adenosine receptors (ARs) identified two deazapurine hits based on 2,6‐diaryl‐7 ...
Ugnė Šinkevičiūtė +9 more
wiley +1 more source
National cohort study on postoperative risks after surgery for submucosal invasive colorectal cancer
, 2019 Background: The decision to perform surgery for patients with T1 colorectal cancer hinges on the estimated risk of lymph node metastasis, residual tumour and risks of surgery.
Dutch T1 Colorectal Cancer Working Group
core
Effect of serum starvation on secretion of exosomes in colorectal cancer HCT116 cells
World Chinese Journal of Digestology, 2016 openaire +1 more source