IGLC3<sup>-</sup> tumor cells drive chemoresistance in colorectal cancer by polarizing SPP1<sup>+</sup> macrophages via the CD44-Wnt-BTF3 axis. [PDF]
Yan F +8 more
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Inhibition of RBM23 induces ferroptosis in colon cancer cells via c-Myc regulation. [PDF]
Oh JJ +8 more
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Acalypha australis L. induces autophagic cell death in colorectal cancer cells by increasing ROS through suppression of the AKT/mTOR/HIF-1 pathway. [PDF]
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Marine Bioactive Peptides for Colorectal Cancer Therapy: Mechanisms, Therapeutic Potential, and Translational Challenges. [PDF]
Lu Y, Wang G, Zhou M, Chen T, Fan Z.
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A novel ZNF263-SMOX-ROS-TRIB3 signaling axis drives Wnt/β-catenin activation and metastatic progression in colorectal cancer. [PDF]
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The pathogenesis of Blastocystis hominis in human hosts has always been a matter of debate as it is present in both symptomatic and asymptomatic individuals. A recent report showed that B. hominis isolated from an asymptomatic individual could facilitate the proliferation and growth of existing cancer cells while having the potential to downregulate ...
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The investigation concerning the B7-H1 expression in colorectal cancer cells is at an early stage. It is unclear whether B7-H1 expression may have diagnostic or prognostic value in colorectal carcinoma. Additionally, how B7-H1 is associated with the clinical features of colorectal carcinoma is not known. In order to investigate the relationship between
Yan-Ling Meng +2 more
exaly +6 more sources
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Effect of TNIK upregulation on JQ1-resistant human colorectal cancer HCT116 cells
Biochemical and Biophysical Research Communications, 2020JQ1 disrupts the binding of bromodomain and extra-terminal (BET) family of proteins to acetylated histones, modulates the expression of various genes, and inhibits the proliferation of cancer cells. We established two JQ1-resistant sublines from human colorectal cancer HCT116 cells. These resistant cells showed an 8- to 9-fold higher resistance to JQ1,
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Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells HCT116
Journal of Cellular Biochemistry, 2018Abstract5‐fluorouracil (5‐FU) and oxaliplatin (OxaPt) are the main chemotherapeutics for colorectal cancer (CRC). Chemotherapy response rates for advanced CRC remain low, primarily due to intrinsic or acquired chemoresistance. The importance of Notch and Wnt signaling for carcinogenesis of CRC as well as crosstalk of Notch and Wnt signaling with many ...
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