Results 191 to 200 of about 33,936 (220)

DIFFERENTIAL GROWTH INHIBITION AND INDUCTION OF APOPTOSIS BY GOSSYPOL BETWEEN HCT116 AND HCT116/BAX^−/– COLORECTAL CANCER CELLS

Clinical and Experimental Pharmacology and Physiology, 2007
SUMMARY Bax is a very important pro‐apoptosis molecule. HCT116/Bax−/– cells do not express the pro‐apoptosis Bcl‐2 family member, Bax. In the present study, the anticancer effects of gossypol on HCT116 and HCT116/Bax−/– cells were compared in terms of inhibition of cell growth, inhibition of colony formation and induction of apoptosis.
Manchao, Zhang, Hongpeng, Liu, Zhenkun, Tian, Jenny, Huang, Mylene, Remo, Q Quentin, Li   +5 more
openaire   +2 more sources

Peloruside A-Induced Cell Death in Hypoxia Is p53 Dependent in HCT116 Colorectal Cancer Cells

Journal of Natural Products, 2018
HCT116 colorectal cancer cell sensitivity to peloruside A (PLA) in normoxia is not altered by hypoxia preconditioning of the cells. We examined whether the PLA effects were altered in hypoxia and whether the activity was dependent on p53. The cytotoxicity of PLA in wild-type HCT116 cells was largely unaffected by hypoxia; however, cells in which p53 ...
Jiří Řehulka, Narendran Annadurai, Ivo Frydrych, Petr Džubák, John H. Miller, Marián Hajdúch, Viswanath Das   +6 more
openaire   +3 more sources

Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK

International Journal of Oncology, 2003
Sodium salicylate is known to induce apoptosis in a variety of cancer cells. However, the molecular mechanism for salicylate-induced apoptosis is yet unclear. Here we show that in HCT116 colon carcinoma cells, 10 mM sodium salicylate induces caspase-3 activation and degradation of its substrates, poly(ADP-ribose) polymerase (PARP), beta-catenin, and ...
Eun Ju, Lee, Hye Geong, Park, Ho Sung, Kang   +2 more
openaire   +2 more sources

Characterization of cancer stem cell drug resistance in the human colorectal cancer cell lines HCT116 and SW480

Biochemical and Biophysical Research Communications, 2017
Cancer stem cells (CSCs) share a number of properties with somatic stem cells including heightened protective mechanisms and the ability to self-renew. CSCs are a critical subpopulation of cancer cells implicated in tumor formation, metastases and recurrence.We used serial colonosphere culture to enrich for CSCs from two human CRC cell lines.
Stacey J. Butler, Lisa Richardson, Nathan Farias, Jodi Morrison, Brenda L. Coomber   +4 more
openaire   +2 more sources

[Effect of indomethacin on human colorectal cancer cells HCT116 and SW480].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2006
To explore the effect of indomethacin on COX non-expressing colon cancer cells (HCT116 and SW480).We used MTT assay to assess the effect of indomethacin on the growth of the cultured cells. Transplanted tumor models were established with BALB/c nude mice and were treated with indomethacin at 3 mg/(kg x d) for 4 weeks. Tumor volume and mouse weight were
Hong-Mei, Wang, Gui-Ying, Zhang
openaire   +1 more source

664 Molecular Mechanisms in Simvastatin-induced HCT116 Colorectal Cancer Cell Apoptosis

European Journal of Cancer, 2012
Material and Methods: Mouse embryonic fibroblasts (MEFs) were isolated and cultured from E11-E13 embryos of control, Sos1-, Sos2or Sos1/2-null mice. To by-pass the lethality of embryos lacking Sos1, tamoxifen-induced Sos1-null mice were generated. Using our available Sos2-mutant mice, double knockout Sos1/Sos2 animals were also produced.
M.J. Hsu, P.T. Chiu, W.H. Kuo, Y.F. Hsu
openaire   +1 more source

Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro

European Journal of Nutrition, 2012
It is relatively unknown how different dietary components, in partnership, regulate gene expression linked to colon pathology. It has been suggested that the combination of various bioactive components present in a plant-based diet is crucial for their potential anticancer activities.
Barrera, Lawrence N, Johnson, Ian T, Bao, Yongping, Cassidy, Aedin, Belshaw, Nigel J   +4 more
openaire   +3 more sources

Butyrate-Induced Apoptosis in HCT116 Colorectal Cancer Cells Includes Induction of a Cell Stress Response

Journal of Proteome Research, 2011
Short chain fatty acids (SCFA), principally butyrate, propionate, and acetate, are produced in the gut through the fermentation of dietary fiber by the colonic microbiotica. Butyrate in particular is the preferred energy source for the cells in the colonic mucosa and has been demonstrated to induce apoptosis in colorectal cancer cell lines.
Fung, K., Brierley, G., Henderson, S., Hoffmann, P., McColl, S., Lockett, T., Head, R., Cosgrove, L.   +7 more
openaire   +3 more sources

[Adiponectin inhibits proliferation and induces apoptosis in colorectal cancer HCT116 cells].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2018
Objective To investigate the relationship between serum adiponectin level and risk of colorectal cancer, and to explore the effect of recombinant adiponectin on the proliferation and apoptosis of colorectal cancer HCT116 cells. Methods Serum adiponectin levels in patients with colorectal cancer and healthy controls were dectected by ELISA.
Manling, Huang, Zhitao, Chen, Dan, Xu, Heng, Zhang, Shengbin, Sun, Jie, Wu   +5 more
openaire   +1 more source

Blastocystis sp. subtype 3 triggers higher proliferation of human colorectal cancer cells, HCT116

Parasitology Research, 2013
Blastocystis sp. is a commonly found intestinal microorganism and was reported to cause many nonspecific gastrointestinal symptoms. Various subtypes have been previously reported, and the pathogenicity of different subtypes of Blastocystis is unclear and remains as a controversial issue.
Kumarasamy, V., Kuppusamy, U.R., Samudi, C., Kumar, S.   +3 more
openaire   +3 more sources