Results 101 to 110 of about 3,050,618 (255)

Differential microRNA expression profiles in HCT116 colorectal cancer cell lines located in the lung and colon

Molecular Medicine Reports, 2014
Colorectal cancer (CRC) is one of the most common types of cancer worldwide. The majority of mortalities caused by colorectal cancer are due to metastatic disease. As numerous CRC patients experience metastasis to the liver or lung and fail to respond to curative therapies, intensive research efforts have sought to identify the molecular changes or ...
Xiao-Hong, Wang, Xin-Min, Yu, Hong, Jiang, Cong, Luo   +3 more
openaire   +3 more sources

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Colorectal cancer: a comparative study of models of health care delivery in two adjacent trusts in South Wales [PDF]

, 2012
Introduction Survival in colorectal cancer patients is dependant on the stage of the cancer at diagnosis. Referral via an appropriate pathway to a specialist service is vital to the early detection of colorectal cancer but there is neither a standard ...
Shah, Parin Rajendra
core  

Taxifolin, a natural flavonoid interacts with cell cycle regulators causes cell cycle arrest and causes tumor regression by activating Wnt/ β -catenin signaling pathway

BMC Cancer, 2018
Background New approaches for the prevention of colon cancer perseveres an essential necessity. Though, resistance to existing chemo-preventive drugs is moderately predominant in colon carcinogenesis.
Suhail Razak, Tayyaba Afsar, Asad Ullah, Ali Almajwal, Musaed Alkholief, Aws Alshamsan, Sarwat Jahan   +6 more
doaj   +1 more source

B7-H1 Expression Is Associated with Poor Prognosis in Colorectal Carcinoma and Regulates the Proliferation and Invasion of HCT116 Colorectal Cancer Cells

PLoS ONE, 2013
The investigation concerning the B7-H1 expression in colorectal cancer cells is at an early stage. It is unclear whether B7-H1 expression may have diagnostic or prognostic value in colorectal carcinoma. Additionally, how B7-H1 is associated with the clinical features of colorectal carcinoma is not known. In order to investigate the relationship between
Sheng-Jia Shi, Li-Juan Wang, Guo-Dong Wang, Zhang-Yan Guo, Ming Wei, Yan-Ling Meng, An-Gang Yang, Wei-Hong Wen   +7 more
openaire   +4 more sources

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas. [PDF]

, 2003
Alcohol is a probable risk factor with regard to colorectal neoplasm and is metabolized to the carcinogen acetaldehyde by the genetically polymorphic alcohol dehydrogenase 3 (ADH3) enzyme.
Ocké, Marga C, Tiemersma, Edine W, Wark, Petra A, Kampman, Ellen, Bunschoten, Annelies, Otten, Marten H, Kok, Frans J   +6 more
core   +3 more sources

Enzyme-catalyzed synthesis of selenium-doped manganese phosphate for synergistic therapy of drug-resistant colorectal cancer

Journal of Nanobiotechnology, 2023
Background The development of multidrug resistance (MDR) during postoperative chemotherapy for colorectal cancer substantially reduces therapeutic efficacy.
Manman Pei, Kaiyuan Liu, Xiao Qu, Kairuo Wang, Qian Chen, Yuanyuan Zhang, Xinyue Wang, Zheng Wang, Xinyao Li, Feng Chen, Huanlong Qin, Yang Zhang   +11 more
doaj   +1 more source

JNK signaling pathway is involved in piperlongumine-mediated apoptosis in human colorectal cancer HCT116 cells

Oncology Letters, 2015
Piperlongumine (PPLGM), an alkaloid isolated from the long pepper (Piper longum L.), can selectively trigger cancer cell death in colorectal cancer cells. The present study investigated whether the c-Jun NH2-terminal kinase (JNK) signaling pathway is involved in PPLGM-induced apoptosis in the human colorectal cancer HCT116 cell line.
Wen, Li, Chuangyu, Wen, Haiyan, Bai, Xiaoyan, Wang, Xiaoli, Zhang, Lanlan, Huang, Xiangling, Yang, Aikichi, Iwamoto, Huanliang, Liu   +8 more
openaire   +3 more sources

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source