Results 81 to 90 of about 33,936 (220)

miR-224 Controls Human Colorectal Cancer Cell Line HCT116 Proliferation by Targeting Smad4 [PDF]

International Journal of Medical Sciences, 2017
Background: Better understanding the molecular mechanisms responsible for the genesis and progression of colorectal cancer would help advance the novel therapeutics. miR-224 has been identified to be elevated in colorectal cancer and promote human colorectal cancer cell line SW480 proliferation and invasion. However, the effect of miRNAs on cancer cell
Zhou, Jinzhe, Hu, Muren, Wang, Fei, Song, Meiyi, Huang, Qi, Ge, Bujun   +5 more
openaire   +2 more sources

Therapeutic Suppression of miR-4261 Attenuates Colorectal Cancer by Targeting MCC

Molecular Therapy: Nucleic Acids, 2017
The mutated in colorectal cancer (MCC) gene is an important colorectal tumor suppressor gene, although few studies have reported the microRNA(s) that could directly target MCC in colorectal cancer.
Guanming Jiao, Qi Huang, Muren Hu, Xuchun Liang, Fuchen Li, Chunling Lan, Wencheng Fu, Yu An, Bin Xu, Jinzhe Zhou, Junjie Xiao   +10 more
doaj   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells

, 2009
Purpose: MLH1 is a key DNA mismatch repair (MMR) protein involved in maintaining genomic stability by participating in the repair of endogenous and exogenous mispairs in the daughter strands during S phase.
Seo, Yuji, Kinsella, Timothy J., Yang, Tao (R15422)   +2 more
core   +1 more source

The Role and Mechanism of Innate Immune Regulation in Overcoming Oxaliplatin Resistance and Enhancing Anti-Tumor Efficacy in Colorectal Cancer

Pharmaceuticals
Background/Objectives: The reversal effect of cGAMP, as a STING pathway regulator, on oxaliplatin resistance in colorectal cancer was investigated, and its mechanism was proposed.
Xiaoqing Wang, Meili Xi, Xing Lu, Xiangshi Tan   +3 more
doaj   +1 more source

Suppression subtractive hybridization identified differentially expressed genes in colorectal cancer: microRNA-451a as a novel colorectal cancer–related gene

Tumor Biology, 2017
To investigate differentially expressed genes regulated by microRNA-451a in colorectal cancer. We detected expression of microRNA-451a in colorectal cancer samples and normal pericarcinous tissues from 68 colorectal cancer patients and the correlation ...
Ke Xu, Yuan-Yuan Zhang, Bin Han, Yang Bai, Yao Xiong, Yi Song, Li-Ming Zhou   +6 more
doaj   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer

, 2020
The chemokine receptor CXCR4 is overexpressed and functional in colorectal cancer. To investigate the role of CXCR4 antagonism in potentiating colon cancer standard therapy, the new peptide CXCR4 antagonist Peptide R (Pep R) was employed.
Antonella Zannetti, Giuseppina Rea, Adelaide Greco, Gerardo Botti, Salvatore Tafuto, Giosuè Scognamiglio, Stefania Scala, Sandra Albanese, Caterina Ieranò, Luigi Portella, Crescenzo D’Alterio, Anna Maria Trotta, Piera Maiolino, Sara Santagata, Guglielmo Nasti, Fabiana Tatangelo, Paolo Delrio, Alessandro Ottaiano, Maria Napolitano, Roberto Pacelli   +19 more
core   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

The expression of long non-coding RNA LINC00941 in colorectal cancer and effect on cell proliferation

四川大学学报. 自然科学版, 2017
To explore the function of a cell differentiation-associated long non-coding RNA (lncRNA) LINC00941 in cancer progression, we detected the expression of LINC00941 in 6 types of human cancer cell lines and HEK-293 cell line by real-time quantitative PCR ...
WANG Cheng-En, LUO Yu, HE Zheng-Chi, XIAO Xue-Wei, LI Zong-Xin, LAN Yang, WU Chuan-Fang   +6 more
doaj