Results 51 to 60 of about 3,050,618 (255)

Activation of WNT7b autocrine eases metastasis of colorectal cancer via epithelial to mesenchymal transition and predicts poor prognosis

BMC Cancer, 2021
Background Aberrant activation of the Wnt/β-catenin signaling pathway is one of the most frequent abnormalities in human cancer, including colorectal cancer (CRC). Previous studies revealed pivotal functions of WNT family members in colorectal cancer, as
Shuai Jiang, Qiwen Li, Yimin Liu, Huimin Zhang, Qianyu Wang, Yu Chen, Xiaoyang Shi, Jun Li, Hailing Zhang, Yi Zhang, Dongqing Xia, Man Wu, Jiajia Lin, Chenglin Zhang, Suhua Pang, Jiamin Jiang, Yan Wen, Peipei Zhang   +17 more
doaj   +1 more source

Completeness of case ascertainment and survival time error in English cancer registries: impact on 1-year survival estimates. [PDF]

, 2011
BACKGROUND: It has been suggested that cancer registries in England are too dependent on processing of information from death certificates, and consequently that cancer survival statistics reported for England are systematically biased and too low ...
Riaz, SP, Holmberg, L, Moller, H.; id_orcid, Hanchett, N., N Hanchett, Richards, S., Robinson, D, L Holmberg, H Møller, S Richards, Riaz, S. P., Richards, S, Holmberg, Lars,, M Lüchtenborg, Riaz, S P, Møller, H, Hanchett, N, Lüchtenborg, M, Lüchtenborg, Margreet, Holmberg, L., S P Riaz, D Robinson, Robinson, D.   +22 more
core   +1 more source

Promotion of colorectal cancer by transcription factor BHLHE40 involves upregulation of ADAM19 and KLF7

Frontiers in Oncology, 2023
BHLHE40 is a transcription factor, whose role in colorectal cancer has remained elusive. We demonstrate that the BHLHE40 gene is upregulated in colorectal tumors.
Yuan Sui, Hanlin Jiang, Collyn M. Kellogg, Sangphil Oh, Sangphil Oh, Ralf Janknecht, Ralf Janknecht, Ralf Janknecht   +7 more
doaj   +1 more source

Association between TAS2R38 gene polymorphisms and colorectal cancer risk [PDF]

, 2011
Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the ...
Stemmler, Susanne, Novotny, Jan, Steinke, Verena, Vodicka, Pavel, Morak, Monika, Hemminki, Kari, Pardini, Barbara, Engel, Christoph, Canzian, Federico, Schackert, Hans K., Naccarati, Alessio, Vodickova, Ludmila, Görgens, Heike, Propping, Peter, Barale, Roberto, Büttner, Reinhard, Försti, Asta, Carrai, Maura, Betz, Beate, Holinski-Feder, Elke, Stein, Angelika, Kloor, Matthias, Rahner, Nils, Campa, Daniele   +23 more
core   +1 more source

Long Non-Coding RNA CKMT2-AS1 Reduces the Viability of Colorectal Cancer Cells by Targeting AKT/mTOR Signaling Pathway

Iranian Journal of Public Health, 2022
Background: Colorectal cancer (CRC) has not only seriously affected people’s lives, but also burdened the government healthcare system. Long non-coding RNAs (lncRNA) have attracted more and more attention in the cancer study field.
Biao Zhuang, Xiong Ni, Zhijun Min, Dejun Wu, Tingfeng Wang, Peng Cui   +5 more
doaj  

Induction of apoptosis in human colorectal cancer cells by nanovesicles from fingerroot (Boesenbergia rotunda (L.) Mansf.).

PLoS ONE, 2022
Colorectal cancer is the leading cause of cancer-related deaths worldwide, warranting the urgent need for a new treatment option. Plant-derived nanovesicles containing bioactive compounds represent new therapeutic avenues due to their unique ...
Saharut Wongkaewkhiaw, Amaraporn Wongrakpanich, Sucheewin Krobthong, Witchuda Saengsawang, Arthit Chairoungdua, Nittaya Boonmuen   +5 more
doaj   +1 more source

N-Heterocyclic Carbene Iron Complexes as Anticancer Agents: In Vitro and In Vivo Biological Studies

Molecules, 2021
Cisplatin and its derivatives are commonly used in chemotherapeutic treatments of cancer, even though they suffer from many toxic side effects. The problems that emerge from the use of these metal compounds led to the search for new complexes capable to ...
Oscar A. Lenis-Rojas, Sandra Cordeiro, Marta Horta-Meireles, Jhonathan Angel Araujo Fernández, Sabela Fernández Vila, Juan Andrés Rubiolo, Pablo Cabezas-Sainz, Laura Sanchez, Alexandra R. Fernandes, Beatriz Royo   +9 more
doaj   +1 more source

Effect of RSK4 on biological characteristics of colorectal cancer

World Journal of Surgical Oncology, 2018
Background This study aimed to investigate the expression of P90 Ribosomal Protein S6 kinase 4 (RSK4) in colorectal cancer cells and its biological function.
Qingqing Ye, Xuan Wang, Min Jin, Meng Wang, Yan Hu, Shihu Yu, Yonghua Yang, Jiyuan Yang, Jun Cai   +8 more
doaj   +1 more source

Coptidis Rhizoma Extract Reverses 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells via Modulation of Thymidylate Synthase

Molecules, 2021
Colorectal cancer (CRC) is a malignancy of the colon or rectum. It is ranked as the third most common cancer in both men and women worldwide. Early resection permitted by early detection is the best treatment, and chemotherapy is another main treatment ...
Yong-Hwi Kang, Jin-Seok Lee, Nam-Hun Lee, Seung-Hyung Kim, Chang-Seob Seo, Chang-Gue Son   +5 more
doaj   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source