Results 31 to 40 of about 3,050,618 (255)

Immune mediated and direct killing of colorectal cancer by reovirus [PDF]

, 2012
Colorectal cancer remains the second most prevalent cancer in the world. Novel treatment strategies are necessary, especially for the treatment of metastatic disease.
Adair, Robert Allan
core   +6 more sources

Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Mutations in the Ras/Raf/MEK/ERK pathway are detected in 50% of colorectal cancer cases and play a crucial role in cancer development and progression.
Shu Gong, Dongsheng Xu, Jialin Zhu, Fangdong Zou, Rui Peng   +4 more
doaj   +1 more source

Recent advances in minimally invasive colorectal cancer surgery [PDF]

, 2002
Laparoscopy has improved surgical treatment of various diseases due to its limited surgical trauma and has developed as an interesting therapeutic alternative for the resection of colorectal cancer.
Wichmann, Mathias W., Rau, H. G., Schildberg, Friedrich Wilhelm, Angele, M. K., Meyer, G., H.G. Rau, F.-W. Schildberg, G. Meyer, M.W. Wichmann, M.K. Angele   +9 more
core   +1 more source

Hybrid liposomes showing enhanced accumulation in tumors as theranostic agents in the orthotopic graft model mouse of colorectal cancer

Drug Delivery, 2018
Hybrid liposomes (HLs) can be prepared by simply sonicating a mixture of vesicular and micellar molecules in a buffer solution. This study aimed to elucidate the therapeutic effects and ability of HLs to detect (diagnosis) cancer in an orthotopic graft ...
Masaki Okumura, Hideaki Ichihara, Yoko Matsumoto   +2 more
doaj   +1 more source

Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase

Journal of Ginseng Research, 2016
Background: Ginsenoside Rh2 (GRh2) is the main bioactive component in American ginseng, a commonly used herb, and its antitumor activity had been studied in previous studies.
Jianjun Yang, Donghong Yuan, Tongchao Xing, Hongli Su, Shengjun Zhang, Jiansheng Wen, Qiqiang Bai, Dongmei Dang   +7 more
doaj   +1 more source

Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved [PDF]

, 2011
Red meat and processed meat intake is associated with a risk of colorectal cancer, a major cause of death in affluent countries. Epidemiological and experimental evidence supports the hypothesis that heme iron present in meat promotes colorectal cancer ...
Bastide, Nadia, Nadia M. Bastide, Denis E. Corpet, Pierre, Fabrice, Pierre, Fabrice H.F., Corpet, Denis E., Fabrice H.F. Pierre   +6 more
core   +1 more source

Discovery of second generation heat shock protein 110 (HSP110) inhibitors for potential treatment of colorectal cancer

European Journal of Medicinal Chemistry Reports, 2023
Heat shock protein 110 (HSP110) is an emerging biological target for development of drug to treat colorectal cancer. In the present study, we designed and synthesized a series of novel small-molecule inhibitors of HSP110 based on previously reported ...
Li Xu, Yuan Wang, Xingrui He, Yuan Gao, Frédéric Lirussi, Yi Zhou, Carmen Garrido, Hang Zhang, Tian Xie, Xiang-Yang Ye   +9 more
doaj   +1 more source

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. [PDF]

, 2011
Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to ...
Tomlinson, IP, A M Jones, Beggs, A. D., Jones, A. M., M Walker, Jones, A.M., Dunlop, MG, Beggs, A.D., Tenesa, A., A D Beggs, Kerr, D, A Zauber, A Tenesa, Hodgson, S. V., Walker, M., M Bertagnolli, R Midgley, Carvajal-Carmona, L, Dunlop, Malcolm, Tenesa, Albert, Tenesa, A, Kerr, D., Jones, AM, Beggs, AD, M G Dunlop, Kerr, David, Jones, A M, Tomlinson, IPM, Carvajal-Carmona, L., Campbell, H.; id_orcid, Tomlinson, I P M, S Ballereau, Tomlinson, I. P. M., Zauber, A., S V Hodgson, Campbell, H, H Campbell, Farrington, S., Hodgson, SV, Ballereau, S., Campbell, H., Midgley, Rachel, Walker, M, S Farrington, I P M Tomlinson, Dunlop, M G, K Howarth, Farrington, S.; id_orcid, Howarth, K., Ballereau, S, Hodgson, S.V., Bertagnolli, M., Tomlinson, I.P., Beggs, A D; id_orcid, Midgley, R., D Kerr, Bertagnolli, M, L Carvajal-Carmona, Hodgson, S V, Dunlop, M. G., Midgley, R, Zauber, A, Howarth, K, Farrington, S   +63 more
core   +1 more source

Intra-tumoral heterogeneity in metastatic potential and survival signaling between iso-clonal HCT116 and HCT116b human colon carcinoma cell lines. [PDF]

PLoS ONE, 2013
Colorectal cancer (CRC) metastasis is a leading cause of cancer-related deaths in the United States. The molecular mechanisms underlying this complex, multi-step pathway are yet to be completely elucidated.
Sanjib Chowdhury, Melanie Ongchin, Elizabeth Sharratt, Ivan Dominguez, Jing Wang, Michael G Brattain, Ashwani Rajput   +6 more
doaj   +1 more source

8-Cl-Adenosine-Induced Inhibition of Colorectal Cancer Growth In Vitro and In Vivo

Neoplasia: An International Journal for Oncology Research, 2000
The cAMP analogue 8-Cl-cAMP induces apoptosis and inhibits proliferation of a wide variety of malignancies in vitro and in vivo with relatively little toxicity.
Chris C. Carlson, Rebecca Chinery, Laura L. Burnham, Daniel T. Dransfield   +3 more
doaj   +1 more source