Results 21 to 30 of about 3,050,618 (255)

The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): The study aimed to investigate the effects of resveratrol on colorectal cancer HCT116 cells, including cell viability, apoptosis, and migration, and the partial mechanisms focused on hedgehog/gli-1 signaling pathways. Materials and Methods:
Zhou Du, Feng Zhou, Zengrong Jia, Beishi Zheng, Shaoliang Han, Jun Cheng, Guanbao Zhu, Ping Huang   +7 more
doaj   +1 more source

Regulation of lnc-TLCD2-1 on Radiation Sensitivity of Colorectal Cancer and Comprehensive Analysis of Its Mechanism

Frontiers in Oncology, 2021
As is well known that colorectal cancer is the third most common cancer in the world, and radiation treatment plays a vital role in colorectal cancer therapy, but radiation resistance is a significant problem in the treatment of colorectal cancer.
Qifeng Yu, Wei Zhang, Xin Zhou, Wenqi Shen, Chungen Xing, Xiaodong Yang   +5 more
doaj   +1 more source

Transcriptome Analysis of the Anti-Proliferative Effects of Ginsenoside Rh3 on HCT116 Colorectal Cancer Cells

Molecules, 2022
The mechanism of ginsenoside Rh3 activity against cancer remains unclear. This study aimed to investigate the underlying mechanism. The effects of Rh3 on the cell proliferation, migration and invasion, and cycle and apoptosis were analyzed using CCK-8 assay, transwell migration assay and flow cytometry, respectively. The RNA transcriptome was sequenced
Siying Teng, Xi Lei, Xinmin Zhang, Dongming Shen, Qiuyi Liu, Yingjie Sun, Yi Wang, Zhongyi Cong   +7 more
openaire   +3 more sources

Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures [PDF]

, 2014
Objective Treatment of colorectal cancer (CRC) remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU)-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50–60%.
Patricia Kraehe, Kraehe Patricia, Shayan, Parviz, Lueders, Cora, Shayan Parviz, Lueders Cora, Shakibaei Mehdi, Mehdi Shakibaei, Parviz Shayan, Goel Ajay, Buhrmann Constanze, Ajay Goel, Cora Lueders, Shakibaei, Mehdi, Constanze Buhrmann, Buhrmann, Constanze, Goel, Ajay, Kraehe, Patricia   +17 more
core   +1 more source

HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia

Disease Models & Mechanisms, 2020
ABSTRACT Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured. Animal models for the study of CRC-induced cachexia, in particular models containing LM, are sparse;
Joshua R. Huot, Leah J. Novinger, Fabrizio Pin, Andrea Bonetto   +3 more
openaire   +3 more sources

Generation of a cancer testis antigen mCherry reporter HCT116 colorectal carcinoma cell line [PDF]

Heliyon, 2018
In the context of cancer immunotherapy, agents that target the immune system to cancer cells need to fulfil two criteria: 1) that they are only expressed on the desired target cell and 2) that they can elicit a potent immunological response. Cancer Testis Antigens are a large disparate family of factors ordinarily expressed in the germ-line but ...
Jyoti B. Chhetri, Elena Drousioti, José Afonso Guerra-Assunção, Javier Herrero, Steen K.T. Ooi   +4 more
openaire   +4 more sources

Genotoxicity and oxidative stress induction by polystyrene nanoparticles in the colorectal cancer cell line HCT116

PLOS ONE, 2021
The potential risks of environmental nanoparticles (NPs), in particular Polystyrene Nanoparticles (PNPs), is an emerging problem; specifically, the interaction of PNPs with intestinal cells has not been characterized so far. The mechanism by which polystyrene particles are transferred to humans has not yet been clarified, whether directly through ...
Giulia Vecchiotti, Sabrina Colafarina, Massimo Aloisi, Osvaldo Zarivi, Piero Di Carlo, Anna Poma   +5 more
openaire   +6 more sources

Increased prevalence of colorectal adenomas in women with breast cancer [PDF]

, 2005
Background: The frequency of colorectal adenomas and carcinomas was investigated in a large cohort of women with breast cancer in comparison with matched controls, since data on the occurrence of second tumors in women with breast cancer is controversial.
Späth, Lydia, Eiermann, Wolfgang, Sackmann, Michael, Göke, Burkhard, Ochsenkühn, Thomas, Wiebecke, Baldur, Bayerdörffer, Ekkehard, Meining, Alexander, Mannes, Gerd Alexander, Ochsenkühn, T;Bayerdörffer, E;Meining, A;Späth, L;Mannes, GA;Wiebecke, B;Eiermann, W;Sackmann, M;Göke, B   +9 more
core   +1 more source

The Genomics of colorectal cancer: State of the art [PDF]

, 2008
The concept of the adenoma-carcinoma sequence, as first espoused by Morson et al. whereby the development of colorectal cancer is dependent on a stepwise progression from adenomatous polyp to carcinoma is well documented.
Hodgson, SV, Hodgson, Shirley V, Beggs, AD, Beggs, Andrew D; id_orcid   +3 more
core   +1 more source

The impact of supplementary narrative-based information on colorectal cancer screening beliefs and intention [PDF]

, 2015
Background: The potential benefits of colorectal cancer screening are limited by low uptake. This study tested whether providing narrative accounts of the colorectal cancer (CRC) screening experience positively affected beliefs about CRC screening and ...
McGregor, Lesley M, von Wagner, Christian, Raine, Rosalind, Wing Chee Yuen, von Wagner, C, Raine, R, Christian von Wagner, Robb, Kathryn A, Vart, Gemma, McGregor, LM, Kathryn A Robb, Robb, KA, Robb, Kathryn A., Jane Wardle, Wardle, Jane, Lesley M McGregor, McGregor, Lesley M., Rosalind Raine, Yuen, WC, Yuen, Wing Chee, Gemma Vart, Wardle, J, Vart, G   +22 more
core   +2 more sources