Results 21 to 30 of about 33,936 (220)

p53 contributes to the chemotherapeutic drug doxorubicininduced cell death in colorectal cancer cell line HCT116 [PDF]

BIO Web of Conferences
Doxorubicin is a commonly used chemotherapy drug for cancer treatment, but its effectiveness varies across different cancer types. p53 is a key factor involved in cell death induced by therapeutic agents.
Deng Rui
doaj   +2 more sources

Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells. [PDF]

Oncol Lett, 2020
Histone deacetylase (HDAC) inhibitors and DNA alkylators are effective components of combination chemotherapy. The aim of the present study was to investigate the possible mechanism of their synergism by detecting the effect of HDAC inhibitors on the expression levels of drug transporters that export DNA alkylators.
Shi B, Xu FF, Xiang CP, Jia R, Yan CH, Ma SQ, Wang N, Wang AJ, Fan P.   +8 more
europepmc   +4 more sources

Dihydrotanshinone I Inhibits the Proliferation and Growth of Oxaliplatin-Resistant Human HCT116 Colorectal Cancer Cells

Molecules, 2022
Oxaliplatin (OXA) is a first-line chemotherapeutic drug for the treatment of colorectal cancer (CRC), but acquired drug resistance becomes the main cause of treatment failure. Increasing evidence has shown that some natural components may serve as chemoresistant sensitizers.
Mengge Wang, Yusen Xiang, Ruyu Wang, Lijun Zhang, Hong Zhang, Hongzhuan Chen, Xin Luan, Lili Chen   +7 more
openaire   +4 more sources

Solubilized antigen of Blastocystis hominis facilitates the growth of human colorectal cancer cells, HCT116

Parasitology Research, 2010
Blastocystis hominis is one of the most common intestinal protozoan parasites in humans, and reports have shown that blastocystosis is coupled with intestinal disorders. In the past, researchers have developed an in vitro model using B. hominis culture filtrates to investigate its ability in triggering inflammatory cytokine responses and transcription ...
Chandramathi, S., Suresh, K., Kuppusamy, U.R.   +2 more
openaire   +4 more sources

Deactivation of CK1α enhances the anti-cancer effects of salinomycin in colorectal cancer HCT116 cells. [PDF]

Biochem Biophys Rep
Salinomycin (Sal), an ion-carrier antibiotic, effectively suppresses cancer growth and metastasis through autophagy or ferroptosis induction, thereby overcoming drug resistance. D4476, a selective inhibitor of casein kinase 1 alpha (CK1α), also inhibits the growth of tumors.
Khakshournia S, Siri M, Zamani M, Bozorg-Ghalati F, Mojtahedi Z, Igder S, Azarpira N, Mokarram P.   +7 more
europepmc   +3 more sources

Benincaside A Induces p53-Dependent Transactivation and Fas/CD95-Mediated Apoptosis in HCT 116 Human Colorectal Cancer Cells [PDF]

Current Issues in Molecular Biology
An undescribed seco-kaurane diterpenoid, benincaside A (BA), was isolated from the seeds of Benincasa hispida. The seeds of B. hispida have been traditionally used in folk medicine and previous studies have reported anti-tumor potential in B.
Jai-Sing Yang, Kun-Ching Cheng, Yu-Hsiu Chuang, Ping-Chung Kuo, Tian-Shung Wu   +4 more
doaj   +2 more sources

The response of chemoresistant human colorectal cancer cells HCT116 to cytotoxic treatment

, 2019
Nepaisant pažangos kolorektalinio vėžio (KRV) diagnostikoje bei gydyme, beveik pusė susirgusiųjų neišgyvena. Viena iš to priežasčių – įgimtas arba gydymo metu įgytas vėžio ląstelių atsparumas chemoterapiniams vaistams. Šiame darbe vertinome autofagijos, Wnt/β-katenino ir Notch1 signalinių kelių reikšmę žmogaus kolorektalinės karcinomos ląstelių HCT116 ...
Kukcinavičiūtė, Eglė,
openaire   +2 more sources

Licochalcone C Inhibits the Growth of Human Colorectal Cancer HCT116 Cells Resistant to Oxaliplatin. [PDF]

Biomol Ther (Seoul)
Licochalcone C (LCC; PubChem CID:9840805), a chalcone compound originating from the root of Glycyrrhiza inflata, has shown anticancer activity against skin cancer, esophageal squamous cell carcinoma, and oral squamous cell carcinoma. However, the therapeutic potential of LCC in treating colorectal cancer (CRC) and its underlying molecular mechanisms ...
Lee SO, Joo SH, Lee JY, Kwak AW, Kim KT, Cho SS, Yoon G, Choi YH, Park JW, Shim JH.   +9 more
europepmc   +3 more sources

A zebrafish HCT116 xenograft model to predict anandamide outcomes on colorectal cancer

Cell Death & Disease, 2022
AbstractColon cancer is one of the leading causes of death worldwide. In recent years, cannabinoids have been extensively studied for their potential anticancer effects and symptom management. Several in vitro studies reported anandamide’s (AEA) ability to block cancer cell proliferation and migration, but evidence from in vivo studies is still lacking.
Francesca Maradonna, Camilla M. Fontana, Fiorenza Sella, Christian Giommi, Nicola Facchinello, Chiara Rampazzo, Micol Caichiolo, Seyed Hossein Hoseinifar, Luisa Dalla Valle, Hien Van Doan, Oliana Carnevali   +10 more
openaire   +6 more sources

Comparative Analyses of Fucoidans from South African Brown Seaweeds That Inhibit Adhesion, Migration, and Long-Term Survival of Colorectal Cancer Cells

Marine Drugs, 2023
Human colorectal cancer (CRC) is a recurrent, deadly malignant tumour with a high incidence. The incidence of CRC is of increasing alarm in highly developed countries, as well as in middle to low-income countries, posing a significant global health ...
Blessing Mabate, Chantal Désirée Daub, Brett Ivan Pletschke, Adrienne Lesley Edkins   +3 more
doaj   +1 more source