Results 41 to 50 of about 84,221 (197)

Synthesis and establishment of physico-chemical constants 2-(5-( chinoline -2-il, 2-hydroxyquinoline-4-іл)-4-R1-1,2,4-triazole-3-ілтіо) acetate acids and their esther

Фармацевтичний журнал, 2018
The large interest in the plan of search biologically of active agents is caused by the heterocyclic system of 1,2,4-triazole, due to high biological activity, and by the low indexes of toxicness, that inherent it to the structural analogues.
Т. М. Kaplaushenko, О. І. Panasenko, Y. G. Samelyuk   +2 more
doaj   +1 more source

The study of the optical activity of some S-derivatives 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1, 2,4-triazole-3-thiols

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
About half of the drugs currently produced are chiral compounds, and about 90 % of these compounds are sold as racemates, consisting of an equimolar mixture of two enantiomers.
Ye. O. Karpun, S. O. Borsuk, L. I. Kucherenko, V. V. Parchenko   +3 more
doaj   +1 more source

MitoSiege‐Driven Catalase Collapse: A GSH‐Responsive, Mitochondria‐Targeted COF Prodrug for Amplified Chemodynamic Therapy

Angewandte Chemie, EarlyView.
The construction of mitochondria‐targeted nanomedicine is achieved by incorporating into COFs a prodrug, which is a catalase inhibitor and a Fenton‐like reaction copper complex linked by a disulfide bond. These findings confer organelle‐specific targeting properties to COF materials for efficient delivery of therapeutic drugs and enhanced cancer ...
Qihang Ding, Bo Wang, Zixuan Zhan, Paramesh Jangili, Junyang Chen, Rakesh Mengji, Hyeonji Rha, Yang Li, Jian Tian, Jong Seung Kim   +9 more
wiley   +2 more sources

Restoring Porosity and Uncovering Flexibility in Pillared 3D‐Linker Metal‐Organic Frameworks

Angewandte Chemie, EarlyView.
This research explores new design approaches towards robust frameworks which retain structural flexibility and porosity after activation. By incorporating bulky 3D‐linkers as anionic pillars with zinc triazolate sheets, moisture‐stable metal‐organic frameworks (MOFs) are synthesized. In situ powder X‐ray diffraction and gas adsorption techniques reveal
Sophie A. Booth, Volodymyr Bon, Connor W. Edwards, G. Paul Savage, Jack D. Evans, Stefan Kaskel, Lauren K. Macreadie   +6 more
wiley   +2 more sources

Computational Study of Ignored Pericyclic Reactions: Rearrangements of 1,2‐Bis(Diazo)Alkanes to 1,2,3,4‐Tetrazines and Subsequent Fragmentations

Angewandte Chemie, EarlyView.
DFT calculations of the 8π‐electrocyclization of 1,2‐bis(diazo)alkanes and of other bis‐1,3‐dipoles reveal that this process can establish a so far ignored route to heterocycles such as 1,2,3,4‐tetrazines. Alternative reaction channels via carbenes or nitrenes leading to fragmentation products are discussed.
Hans‐Ulrich Reissig, Ernst‐Ulrich Würthwein   +1 more
wiley   +2 more sources

Antibacterial and antifungal activity of derivatives 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
The amount of antibiotics has increased over the past decade. This also resulted in increase of microorganisms’ resistance to this class of drugs. Therefore, the synthesis of new compounds that have exhibited antimicrobial and antifungal activity and low
O. A. Suhak, O. І. Panasenko, Ye. G. Knysh, O. M. Kamyshny   +3 more
doaj   +1 more source

Electrochemical ⍺‐C─H Functionalization of Nitramines for Accessing Bifunctional Energetic Heterocycles

Angewandte Chemie, EarlyView.
An electrochemical α‐C─H functionalization of nitramines enables the synthesis of molecules containing bifunctional energetic heterocycles with promising properties. A telescoped, HNO3‐free sequence involving nitration and azolation steps offers a safer, modular, and scalable platform for the synthesis of energetic compounds.
Wan‐Chen Cindy Lee, Luiz F. T. Novaes, Rojan Ali, Thomas Wirth, Song Lin   +4 more
wiley   +2 more sources

Experimental Study on Decomposition and Evaporation Characteristics of N,N,N′,N′-Tetramethylethylenediamine and 1,2,4-Triazole

Energies, 2019
N,N,N′,N′-Tetramethylethylenediamine (TMEDA) is one of the candidate substances of hydrazine for hypergolic bipropellant applications. In this study, two experimental analyses were performed to investigate the characteristics of TMEDA and ...
Jungmin Yu, Seung Wook Baek, Sung June Cho   +2 more
doaj   +1 more source

Synthesis and Characterization of the Triazole Derived from Thiosemicarbazide, 4-Amino-5-Phenyl-4H-1,2,4- Triazole-3-Thiol and Their Copper(II) and Nickel(II) Complexes [PDF]

Engineering and Technology Journal, 2013
Triazole N-(3-mercapto-5-phenyl-4H-1,2,4-triazol-4-yl)hydrazinecarbothioamide prepared in good yield via the condensation of 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol and thiosemicarbazide.
Hamdan Abood Aday
doaj   +1 more source

Impact of Lattice Heterogeneity on Broadband Optical Retardation in Stacked 2D Perovskite Single Crystals

Advanced Functional Materials, EarlyView.
It is shown that interfaces between organic and inorganic layers govern long‐range stacking disorder and in‐plane anisotropy in 2D metal‐halide perovskites. By comparing single‐cation AB‐AB and ordered mixed‐cation ABCD‐ABCD stackings, SCXRD reveals enhanced mosaicity, while optics confirm high birefringence.
Yixuan Dou, Nicholas Nici, Sunhao Liu, Xiaoming Wang, Yanfa Yan, Carla Slebodnick, Lina Quan   +6 more
wiley   +1 more source