Results 21 to 30 of about 24,912 (203)

Iridium‐Catalyzed Ionic Hydrogenation of Multi‐Aza Heterocycles

open access: yesAngewandte Chemie, EarlyView.
Saturated nitrogen‐containing heterocycles are ubiquitous in bioactive molecules and are thus attractive synthetic targets. A readily accessible cyclometalated iridium(III) complex reduces 14 different aromatic aza heterocycles to (partially)saturated multi aza‐heterocycles enlarging accessible chemical space while displaying high tolerance toward ...
Arthur Despois, Nicolai Cramer
wiley   +2 more sources

Pharmacological aspects of application of 1,2,4-triazole-3-thiol furan derivatives

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
Introduction. Nowadays 1,2,4-triazole-3-thiol furan derivatives have established themselves as a separate class of promising bioactive compounds. Presented substance is practically non-toxic and exhibits various kinds of pharmacological activity.
O. A. Bihdan   +3 more
doaj   +1 more source

Sur la formation «prébiotique» de peptides. Influence d’azoles non condensés et particulièrement du triazole-1,2,4 sur la condensation d’acides α-aminés en milieu aqueux par les polyphosphates

open access: yesCHIMIA, 1981
With the addition of 1,2,4-triazole or imidazole to aqueous solutions 0.1 M in glycine and 0.1 M in trimetaphosphate at room temperature, pH range 6.7-8.9, the yield of triglycine is improved by a factor of 10 to 20; the best yields are obtained with 1 ...
J. Rabinowitz, A. Hampai
doaj   +1 more source

Molecularly Templated Buried Interfaces for Inverted Perovskite Solar Cells

open access: yesAngewandte Chemie, EarlyView.
We demonstrate a molecularly matched buried interface between SAM and perovskite, enhancing adhesion and passivating defects. This optimized interface achieves 26.58% power conversion efficiency and 86.72% fill factor with exceptional operational stability in both large‐area and wide‐bandgap devices, thereby increasing efficiency and prolonging ...
Songyang Yuan   +19 more
wiley   +2 more sources

Synthesis methods of 1,2,4-triazole-3-thiones: review

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
1,2,4-Triazole-containing compounds are unique heterocyclic compounds present in an array of pharmaceuticals and biologically important compounds used in drug-discovery studies against cancer cells, microbes, and various types of diseases in the human ...
Yu. S. Frolova   +3 more
doaj   +1 more source

Study acute toxicity of 4-(R-amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol in vivo

open access: yesФармацевтичний журнал, 2018
Typically, the system is already known are used as the core for a new substance, which have already proved themselves as potential drugs. So one of these is 1,2,4-triazole ring.
A. A. Safonov
doaj   +1 more source

1,2,4-Triazoles. IV. Tautomerism of 3,5-disubstituted 1,2,4-triazoles.

open access: yesChemical and Pharmaceutical Bulletin, 1975
Tautomerism of ten 3, 5-disubstituted 1, 2, 4-triazoles, which can exist in three tautomeric forms, has been studied. The nuclear magnetic resonance (NMR) and ultraviolet (UV) spectra of these 1, 2, 4-triazoles were compared with those of the N-methyl derivatives, which are the model compounds of the three kinds of tautomeric forms.
KUBOTA, SEIJU, UDA, MASAYUKI
openaire   +2 more sources

Synthesis and establishment of physico-chemical constants 2-(5-( chinoline -2-il, 2-hydroxyquinoline-4-іл)-4-R1-1,2,4-triazole-3-ілтіо) acetate acids and their esther

open access: yesФармацевтичний журнал, 2018
The large interest in the plan of search biologically of active agents is caused by the heterocyclic system of 1,2,4-triazole, due to high biological activity, and by the low indexes of toxicness, that inherent it to the structural analogues.
Т. М. Kaplaushenko   +2 more
doaj   +1 more source

Antibacterial and antifungal activity of derivatives 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
The amount of antibiotics has increased over the past decade. This also resulted in increase of microorganisms’ resistance to this class of drugs. Therefore, the synthesis of new compounds that have exhibited antimicrobial and antifungal activity and low
O. A. Suhak   +3 more
doaj   +1 more source

Experimental Study on Decomposition and Evaporation Characteristics of N,N,N′,N′-Tetramethylethylenediamine and 1,2,4-Triazole

open access: yesEnergies, 2019
N,N,N′,N′-Tetramethylethylenediamine (TMEDA) is one of the candidate substances of hydrazine for hypergolic bipropellant applications. In this study, two experimental analyses were performed to investigate the characteristics of TMEDA and ...
Jungmin Yu   +2 more
doaj   +1 more source

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