Results 11 to 20 of about 24,543 (214)
1,2,4-Triazoles as Important Antibacterial Agents [PDF]
Pharmaceuticals, 2021 The global spread of drug resistance in bacteria requires new potent and safe antimicrobial agents. Compounds containing the 1,2,4-triazole ring in their structure are characterised by multidirectional biological activity. A large volume of research on triazole and their derivatives has been carried out, proving significant antibacterial activity of ...
Małgorzata Strzelecka, Piotr Świątek
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1,2,4-Triazoles. VII. Methylation of 1,2,4-triazoles.
Chemical and Pharmaceutical Bulletin, 1976 The methylations of twenty-five 1, 2, 4-triazoles with methyl iodide and diazomethane were studied and substituent effects on the product ratios are discussed. Methylation of 1, 2, 4-triazole and its symmetrically 3, 5-disubstituted derivatives occurred almost exclusively at the 1-position.
UDA, MASAYUKI +3 more
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Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017 Introduction. Currently an attempt to combine 1,2,4-triazole heterocycle with various pharmacologically active fragments of other organic molecules is popular among the scientists.
O. A. Bihdan, V. V. Parchenko
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Synthesis and alkylation of 5-aryl-1,2-dihydro-3H-1,2,4-triazole-3-thiones
Журнал органічної та фармацевтичної хімії, 2021 5-R-1,2,4-triazole-3-thiones and their derivatives are easy to obtain; they have low toxicity and a broad spectrum of the biological activity. It makes this class of heterocyclic compounds promising for creating potential drugs. Aim.
Dmytro V. Dovbnya +2 more
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Журнал органічної та фармацевтичної хімії, 2021 Aim. To synthesize 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and study its reactivity in the reaction with aldehydes. Results and discussion.
D. М. Zozulynets +2 more
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Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016 Aim. To study the effect of 4-benzylideneamino-5-phenyl-4H-1,2,4-triazole-3-thiones and salts of 2-(4-amino-5-phenyl-4H-1,2,4-triazole-3-yltio)acetic acid on central component of nociceptive system on condition of thermal stimulation of limbs of rats ...
Ye. S. Pruhlo
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Pharmacological aspects of application of 1,2,4-triazole-3-thiol furan derivatives
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016 Introduction. Nowadays 1,2,4-triazole-3-thiol furan derivatives have established themselves as a separate class of promising bioactive compounds. Presented substance is practically non-toxic and exhibits various kinds of pharmacological activity.
O. A. Bihdan +3 more
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Synthesis of some New 1,2,4-Triazole derivatives [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2013 In the present work, compound 3-arylidene amino-5-methyl-1,2,4-triazole (IIIa-c), required as starting material obtained in one-pot reaction by condensing 5-methyl-3-amino-1,2,4-triazole with different aromatic aldehydes.
Ibtehal Kahtan Abdullah
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1,2,4-Triazoles. IV. Tautomerism of 3,5-disubstituted 1,2,4-triazoles.
Chemical and Pharmaceutical Bulletin, 1975 Tautomerism of ten 3, 5-disubstituted 1, 2, 4-triazoles, which can exist in three tautomeric forms, has been studied. The nuclear magnetic resonance (NMR) and ultraviolet (UV) spectra of these 1, 2, 4-triazoles were compared with those of the N-methyl derivatives, which are the model compounds of the three kinds of tautomeric forms.
KUBOTA, SEIJU, UDA, MASAYUKI
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Pyridine C─N Transposition via Cycloaddition–Cycloreversion
Angewandte Chemie, EarlyView.Transposition of pyridine nitrogen from the 4‐ to the 3‐position is described using two open and shut sequences: a nucleophile addition ring‐open ring‐closure, followed by a nitrile Diels–Alder cycloaddition cycloreversion. The nitrogen swap is particularly effective for tertiary alkyl substituents, transforming easily accessible para‐alkylated ...
Aífe Conboy, Michael F. Greaney
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