Results 11 to 20 of about 24,912 (203)

Acute toxicity of 5-(2-, 3-, 4-methoxyphenyl, (3,4,5-trimethoxyphenyl)-)-1,2,4-triazole-3-thiones and its thioderivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
Aim. We have continued the study of 1,2,4-triazole derivatives, which contain 2-, 3- , 4-methoxyphenyl or 3,4,5- methoxyphenyl substituents in 5th position of the triazole nucleus.
Yu. G. Samelyuk , A. G. Kaplaushenko
doaj   +1 more source

The search for new 4-amino-5-methyl-4H-1,2,4-triasole-3-thion derivatives with diuretic activity

Zaporožskij Medicinskij Žurnal, 2018
1,2,4-Triazole derivatives have been widely used in medical practice due to their wide spectrum of biological activities and low toxicity, as they have 1,2,4-triazole cycle in their structure.
T. V. Kravchenko
doaj   +1 more source

Dataset on theoretical bio-evaluation of 1,2,4-thiadiazole-1,2,4-triazole analogues against epidermal growth factor receptor kinase down regulating human lung cancer

Data in Brief, 2021
Data from eight 1,2,4-thiadiazole-1,2,4-triazole derivatives were used to observe the anti-epidermal growth factor receptor kinase activities of 1,2,4-thiadiazole-1,2,4-triazole analogues thereby reducing human lung cancer.
Abel Kolawole Oyebamiji, Sunday Adewale Akintelu, Oreoluwa P. Amao, Mary Oluwatosin Kaka, Adetoun E. Morakinyo, Folake Ayobami Amao, Banjo Semire   +6 more
doaj   +1 more source

Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Introduction. Currently an attempt to combine 1,2,4-triazole heterocycle with various pharmacologically active fragments of other organic molecules is popular among the scientists.
O. A. Bihdan, V. V. Parchenko
doaj   +1 more source

Synthesis and alkylation of 5-aryl-1,2-dihydro-3H-1,2,4-triazole-3-thiones

Журнал органічної та фармацевтичної хімії, 2021
5-R-1,2,4-triazole-3-thiones and their derivatives are easy to obtain; they have low toxicity and a broad spectrum of the biological activity. It makes this class of heterocyclic compounds promising for creating potential drugs. Aim.
Dmytro V. Dovbnya, Andrii G. Kaplaushenko, Alla S. Korzhova   +2 more
doaj   +1 more source

The synthesis of 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and its interaction with aldehydes

Журнал органічної та фармацевтичної хімії, 2021
Aim. To synthesize 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and study its reactivity in the reaction with aldehydes. Results and discussion.
D. М. Zozulynets, A. G. Kaplaushenko, A. S. Korzhova   +2 more
doaj   +1 more source

Selective Adsorption of o‐Xylene From all C8 Aromatics via Secondary Connectivity Manipulation in B←N Frameworks

Angewandte Chemie, EarlyView.
A programmed assembly strategy based on secondary connectivity integration allows modulating the B←N framework (BNF) microenvironment. Beyond possessing improved stability, the resulting BNFs achieve highly selective adsorption of o‐xylene from all C8 aromatics.
Xiang‐Shuai Li, Yizhou Wang, Wing‐Laam Luk, Jieying Hu, Rong Fu, Zhao Zhang, Zenan Chen, Jian Zhao, Wan Chan, Yangjian Quan   +9 more
wiley   +2 more sources

Generalizable Strategies for the Synthesis of Cereblon‐Recruiting PROTAC Prodrugs

Angewandte Chemie, EarlyView.
Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Aiden X. Wang, Bin Liu, Elise M. Ackerman, Yichen Xiang, Hung V.‐T. Nguyen, Yivan Jiang, Angela N. Koehler, Jeremiah A. Johnson   +7 more
wiley   +2 more sources

Effect of 4-benzylidenamino-5-phenyl-4Н-1,2,4-triazole-3-thiones and salts of 2-(4-amino-5-phenyl-4Н-1,2,4-triazole-3-ylthio)acetic acid on central component of nociceptive system

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
Aim. To study the effect of 4-benzylideneamino-5-phenyl-4H-1,2,4-triazole-3-thiones and salts of 2-(4-amino-5-phenyl-4H-1,2,4-triazole-3-yltio)acetic acid on central component of nociceptive system on condition of thermal stimulation of limbs of rats ...
Ye. S. Pruhlo
doaj   +1 more source

Synthesis of some New 1,2,4-Triazole derivatives [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2013
In the present work, compound 3-arylidene amino-5-methyl-1,2,4-triazole (IIIa-c), required as starting material obtained in one-pot reaction by condensing 5-methyl-3-amino-1,2,4-triazole with different aromatic aldehydes.
Ibtehal Kahtan Abdullah
doaj   +1 more source