Results 41 to 50 of about 24,543 (214)
Proton-Conducting Polymeric Membranes Based on 1,2,4-Triazole
Membranes, 2023 In this review, a comparative analysis of the literature and our own results obtained in the study of the physicochemical, dielectric, and proton-conducting properties of composite polymer materials based on 1H-1,2,4-triazole has been carried out. It has
Galina F. Prozorova +1 more
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Thermal Rearrangement of Allyl Substituted Unsymmetric 4H-1,2,4-Triazoles to the Corresponding 1H-1,2,4-triazoles [PDF]
Molecules, 2001 A series of neat 4-(2-alkenyl) substituted 5-methyl-3-phenyl-4H-1,2,4-triazoles were thermolyzed at 320 oC producing a rearrangement products, of which the regioisomeric 1- and 2-substituted triazoles were the main products. The group migrations were rationalized in terms of consecutive SN2-type reactions. This mechanism was supported by a study of the
Kåre B. Jørgensen +2 more
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Angewandte Chemie, EarlyView.Die Kontrolle biologischer Systeme mit organischen Chromophoren hat sich zu einer vielversprechenden Strategie entwickelt und findet Anwendung von der chemischen Biologie bis hin zur Medizin. Die Komplexität von In‐vivo‐Systemen lässt sich jedoch nicht mit nur einer einzigen Lichtwellenlänge adäquat abbilden.
Nadja A. Simeth
wiley +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019 A large number of native and foreign scientists are involved in the synthesis of 3-thio-1,2,4-triazole. Today, a huge number of drugs based on 3-thio-1,2,4-triazole has been created, including itraconazole, fluconazole, voriconazole, letrozole ...
T. V. Ihnatova +2 more
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5-Amino-3-(4H-1,2,4-triazol-4-yl)-1H-1,2,4-triazole [PDF]
Acta Crystallographica Section E Structure Reports Online, 2012 The asymmetric unit of the title compound, C(4)H(5)N(7), comprises two independent but virtually superimposable mol-ecules. Each mol-ecule is planar with the dihedral angles between the five-membered rings being 2.8 (3) and 2.1 (3)°. The crystal structure is formed by an extensive network of relatively strong N-H⋯N hydrogen-bond inter-actions ...
Bing Liu +3 more
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Synthesis of New Bis-1,2,4-Triazole Derivatives [PDF]
Molecules, 2006 A series of new 1,2/1,3-bis[o-(N-methylidenamino-3-aryl-5-phenyl-4H-1,2,4-triazole-4-yl)phenoxy]ethane/propane derivatives 4 were prepared in good yields bytreatment of 4-amino-3-aryl-5-phenyl-4H-1,2,4-triazoles 2 with certain bis-aldehydes 1.Compounds 4 were reduced with NaBH4 to afford the corresponding 1,2/1,3-bis[o-(N-methylamino-3-aryl-5-phenyl-4H-
Bekircan, Olcay, Bektas, Hakan
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Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges
Angewandte Chemie International Edition, EarlyView.Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley +1 more source
3-Phenyl-1H-1,2,4-triazol-5-amine–5-phenyl-1H-1,2,4-triazol-3-amine (1/1)
Acta Crystallographica Section E, 2009 In the title compound, C8H8N4·C8H8N4, two tautomers, viz. 3-phenyl-1,2,4-triazol-5-amine and 5-phenyl-1,2,4-triazol-3-amine, are crystallized together in equal amounts.
Anton V. Dolzhenko +4 more
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3-Nitro-1H-1,2,4-triazole [PDF]
Acta Crystallographica Section E Structure Reports Online, 2010 تحتوي الوحدة غير المتماثلة لمركب العنوان، C(2)H(2)N(4)O(2)، على جزيئتين مستقلتين بلوريًا تكون فيهما حلقات التريازول مستوية بشكل أساسي، مع انحرافات قصوى قدرها 0.003 (1) Å في كلا الجزيئين. الزاوية الثنائية السطوح بين حلقتي 1H -1،2،4 - triazole هي 56.58 (5)درجة.
Madhukar Hemamalini, Hoong‐Kun Fun
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Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor
Bulletin of the Korean Chemical Society, EarlyView.This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim +8 more
wiley +1 more source