Results 81 to 90 of about 84,221 (197)

Design, Synthesis, and Molecular Docking of Triazole‐Coumarin Hybrids as Potent Breast Cancer Inhibitors Targeting Cell Cycle and Apoptosis

Chemistry &Biodiversity, EarlyView.
Triazole‐coumarin hybrids were synthesized as breast cancer inhibitors. Derivative 5f induced S‐phase arrest and apoptosis in cancer cells, with minimal toxicity to healthy cells, showing promise for anticancer drug development. ABSTRACT Breast cancer continues to pose a significant global health burden, highlighting the urgent need for novel ...
Murat Keser, Emre Menteşe, Suleyman Ilhan, Mustafa Emirik, Harika Atmaca   +4 more
wiley   +1 more source

Heterocyclization reactions study of 3-thio and 3-thio-4-amino derivatives of 1,2,4–triazole

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Scientific publications of recent years clearly demonstrate the prospects of finding new molecules among 1,2,4-triazole derivatives. The whole series of drugs, which are 1,2,4-triazole derivatives (fluconazole, ribavirin, avesstym, tryfuzol and others ...
O. A. Bihdan, O. I. Panasenko, Ye. G. Knysh, V. V. Parchenko   +3 more
doaj   +1 more source

The Chemistry of Subphthalocyanines: Synthetic Strategies for their Axial, Peripheral, and Remote Postfunctionalization

ChemistryEurope, EarlyView.
From axial and peripheral reactivity to remote derivatization, the chemical versatility of subphthalocyanines (SubPcs) renders them ideal scaffolds for the design of advanced functional materials. This review assembles the synthetic toolbox, key reaction conditions, and future challenges in SubPc functionalization, guiding the development of next ...
Marta Gómez‐Gómez, Juan Laforga‐Martín, Jorge Labrador‐Santiago, Jorge Labella, Tomás Torres   +4 more
wiley   +1 more source

Synthesis, physic and chemical properties of 2-(4-R-5-(thiophene-2-ylmethyl)-4h-1,2,4-triazole-3-ylthio)acetate acids and their salts

Фармацевтичний журнал, 2018
Derivatives of 1,2,4-triazole are inherent in various types of biological activity. They can be used as pesticide and medicinal drugs (anticonvulsants, analgetics, antitumor and antibacterial).
O. A. Suhak, О. I. Panasenko, Ye. G. Knysh   +2 more
doaj   +1 more source

Thiocarbamoylimidates as Precursors of New 5‐Amino‐1,2,4‐Triazole and Oxadiazole Derivatives In Silico Prediction of Absorption, Distribution, Metabolism, and Excretion Parameters

ChemPlusChem, EarlyView.
1,2,4‐triazole and oxadiazole motifs are synthesized from thiocarbamoylimidates precursors, under mild conditions (40 °C) in the environmentally friendly water/ethanol reaction medium. The reaction is highly versatile and allows for the introduction of a wide variety of functional groups.
Oumaima Gatri, Thierry Roisnel, Marie Cordier, Vincent Dorcet, Mohamed Lotfi Efrit, Cédric Fischmeister   +5 more
wiley   +1 more source

Acute toxicity of 3-(2-, 3-fluorophenyl)-6-(aryl-, hetaryl)-[1,2,4]triazole[3,4-b][1,3,4]thiadiazoles

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Nowadays an attempt to create a number of new biologically active compounds by many scientific groups is being one of the topical issues in the domestic pharmaceutical industry.
O. A. Bihdan, V. V. Parchenko
doaj   +1 more source

Can Gas Absorption be Tuned in a Multifunctional Ionic Liquid?

ChemSusChem, EarlyView.
A multifunctional phosphonium triazolate ionic liquid is capable of reversibly absorbing CO2 at high capacity while decreasing viscosity. The addition of ZIF‐8 leads to a porous ionic liquid with enhanced physical absorption, however, an unexpected loss of porosity occurs in the presence of CO2.
Frederik Philippi, Margarida Costa Gomes
wiley   +1 more source

Anticonvulsant activity 2-((5-(3-(4-fluorophenyl)-4-R2-1,2,4-triazole-3-yl)-thio)-1-arylethanone

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
The aim of work is to study of the anticonvulsant activity of 2-((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazole-3-yl)thio)-1-aryletanones, the establishment of some laws between the structure of compounds and their activity. Materials and methods.
O. A. Bihdan
doaj   +1 more source

Surveying the Homogeneity of a Molecular Electrocatalyst Embedded in a Metal‐Organic Framework Using Operando Characterization

ChemSusChem, EarlyView.
A detailed study of the homogeneity changes exhibited by a molecular Cu catalyst embedded in a MOF during the oxygen reduction reaction. Operando X‐ray absorption spectroscopy reveals a transformation from a molecular Cu2+ catalyst to Cu0 clusters <2 nm, emphasizing the risk of attributing high catalytic performance to molecular catalysts that have ...
Marlene E. Hoefnagel, Jan S. D. Rodriguez, Sergi Campos‐Jara, Oleg Usoltsev, Dennis G. H. Hetterscheid, Sheena Louisia   +5 more
wiley   +1 more source

Theoretical Study of Tautomeric Conformations for 1,2,4-Triazole Derivatives

Orbital: The Electronic Journal of Chemistry, 2021
We have performing theoretical calculations of the 1,2,4-triazole derivatives using DFT B3LYP method to study the tautomeric conformations of 1,2,4-triazole-3-thiol (TL 2A and TL 2C) and 1,2,4-triazole-3-thione (TL 2B) derivatives.
Radia Mahboub
doaj