Results 71 to 80 of about 24,912 (203)

Synthesis, physic and chemical properties of 2-(4-R-5-(thiophene-2-ylmethyl)-4h-1,2,4-triazole-3-ylthio)acetate acids and their salts

Фармацевтичний журнал, 2018
Derivatives of 1,2,4-triazole are inherent in various types of biological activity. They can be used as pesticide and medicinal drugs (anticonvulsants, analgetics, antitumor and antibacterial).
O. A. Suhak, О. I. Panasenko, Ye. G. Knysh   +2 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Benzimidazol‐2‐One Hybrids as Potential Anti‐Alzheimer's Disease Agents

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder for which single‐target therapies often provide insufficient benefit, motivating the development of multi‐target‐directed ligands (MTDLs). In this study, a novel series of benzimidazolone‐based hybrids incorporating piperazine, coumarin, and triazole moieties was designed,
Fatih Yılmaz, Emre Menteşe, Ozan Emre Eyüpoğlu, Bahittin Kahveci, Mustafa Emirik   +4 more
wiley   +1 more source

Acute toxicity of 5-(furan-2-yl, 2-metylfuran-3-yl)-4-amino-1,2,4-triazole-3-thiol alkyl derivatives

Zaporožskij Medicinskij Žurnal, 2017
The purpose of our work was the further exploration of the new 5-(furan-2-yl, 2-metylfuran-3-yl)-4-amino-1,2,4-triazole-3-thiol alkyl derivatives’ acute toxicity, setting some patterns of alkyl substituents influence by the Sulfur atom on the acute ...
D. M. Danilchenko, V. V. Parchenko
doaj   +1 more source

Boosting Zinc‐Ion Hybrid Capacitors with Mesoporous Carbon Derived from Highly Graphitized Carbon Quantum Dots

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 5, September 2026.
The work presents an innovative method for the preparation of mesoporous carbon materials (MCs) from highly graphitized carbon quantum dots. The zinc‐ion hybrid capacitors assembled with MCs deliver high rate performance and stability, providing promising advancements for future energy storage solutions.
Guoli Zhang, Huihui Li, Kaiyue Wang, Gang Li, Kaixi Li, Taotao Guan, Kaiying Wang   +6 more
wiley   +1 more source

Comparing Chemoenzymatic and Conventional Synthetic Strategies to Wall Teichoic Acid Peptidoglycan Fragments

Israel Journal of Chemistry, Volume 66, Issue 5, September 2026.
The Gram‐positive bacteria, Staphylococcus aureus, contain wall teichoic acid (WTA, a glycopolymer (green and yellow)) is a virulence factor in their cell wall. Synthesis of the peptidoglycan‐(PG)‐WTA conjugate (blue squares) was developed via the phospho‐donor and PG acceptor (structures at the bottom right).
Min Liu, Kathleen C. Stathoulopoulos, Catherine Leimkuhler Grimes   +2 more
wiley   +1 more source

Evaluation of antioxidant activity of 1,2,4-triazole derivatives in the initiation of free radical processes

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
The activation of lipid free radical oxidation is a key stage in the development of many diseases and can lead to the emergence of related complications.
I. M. Bilai, V. I. Dariy, A. V. Khilkovets, A. I. Bilai, I. F. Duiun   +4 more
doaj   +1 more source

MtGRF8 interacts with MtSymCRK and prevents early bacteroid death during Medicago – Sinorhizobium symbiosis

New Phytologist, Volume 251, Issue 5, Page 2867-2887, September 2026.
MtSymCRK–MtGRF8‐14‐3‐3a, e, h and i functional model in R‐108 nodules. Summary In Medicago littoralis R‐108, Symbiotic CYSTEINE‐RICH RECEPTOR‐LIKE KINASE (MtSymCRK) is required to prevent defense reactions in symbiotic nodules during chronic infection.
Chaoyan Yin, Kévin Magne, Fathi Berrabah, Dario Monachello, Gautier Bernal, Kirankumar S. Mysore, Jiangqi Wen, Catherine Etchebest, Pascal Ratet, Véronique Gruber   +9 more
wiley   +1 more source

The Stabilization of High‐Nitrogen Systems: 10 Catenated Nitrogen Chain

Chemistry – A European Journal, Volume 32, Issue 31, 18 August 2026.
Improving the understanding of high‐nitrogen materials. ABSTRACT High‐nitrogen materials have attracted intense interest in recent decades due to their unique chemical, physical, and biological properties. Stabilizing high‐nitrogen materials is often challenging as they become more unstable with increasing nitrogen catenation and nitrogen mass ...
Nicholas F. Scherschel, Thomas R. Talbot IV, Matthias Zeller, Davin G. Piercey   +3 more
wiley   +1 more source

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, Volume 32, Issue 31, 18 August 2026.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Synthesis, physical-chemical properties of 2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Aim. Analysis of the scientific literature over the past decade has shown that large synthetic possibilities towards creating new and effective drug substances have heterocyclic compounds, in particular the derivatives of 1,2,4-triazole.
O. A. Suhak, O. I. Panasenko, Ye. G. Knysh   +2 more
doaj   +1 more source