Results 81 to 90 of about 24,912 (203)

Structural Modifications of Nonsteroidal Anti‐Inflammatory Drugs (NSAIDs): New Horizons in Antimicrobial Drug Discovery

open access: yesArchiv der Pharmazie, Volume 359, Issue 8, August 2026.
This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Ebru Koçak Aslan   +2 more
wiley   +1 more source

The roles of side chains in Y6‐series non‐fullerene acceptors for high‐performance organic solar cells

open access: yesBulletin of the Korean Chemical Society, Volume 47, Issue 8, Page 900-922, August 2026.
The development of organic solar cells (OSCs) has been driven by structural modifications of Y6‐series non‐fullerene acceptors. In particular, side‐chain engineering regulates solubility, molecular packing, and energy levels, enabling efficiencies to increase from 15.7% to over 20%.
Peddaboodi Gopikrishna   +3 more
wiley   +1 more source

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

open access: yesDrug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq   +6 more
wiley   +1 more source

Synergetic Ruthenium Clusters and Ligand Motifs in Insoluble Polyoxometalates for Efficient Urea Electrosynthesis

open access: yesRare Metals, Volume 45, Issue 8, August 2026.
ABSTRACT The electrocatalytic co‐reduction of CO2 and nitrate (NO3− ${\text{NO}}_{3}^{-}$) to synthesize urea presents a sustainable alternative to traditional industrial processes, yet its efficiency is fundamentally limited by the kinetically mismatched activation and coupling of CO2 and NO3− ${\text{NO}}_{3}^{-}$.
Jiayu Liu   +9 more
wiley   +1 more source

Dimethyl‐, Diethyl‐, and Propylene Carbonates: An Emerging Class of Green Solvents for Organic Synthesis

open access: yesThe Chemical Record, Volume 26, Issue 8, August 2026.
This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros   +5 more
wiley   +1 more source

Accumulation of Histidine Reduce the Susceptibility of Vibrio splendidus Persister Cells to Tetracycline

open access: yesEnvironmental Microbiology Reports, Volume 18, Issue 4, August 2026.
Histidine accumulation promotes tetracycline‐induced persister formation in V. splendidus. It enhances membrane potential and upregulating the efflux pump gene, thereby reducing antibiotic susceptibility. ABSTRACT Vibrio splendidus is an opportunistic pathogen widely distributed in marine environments, animal tissues and seabed sediments. It can infect
Yanan Li   +4 more
wiley   +1 more source

Transcriptional Regulation of the Novel Theacrine Synthase Gene CsTcS2 by the CsTINY–CsWRKY33 Module Underpins Theacrine Biosynthesis in Camellia sinensis

open access: yesPlant Biotechnology Journal, Volume 24, Issue 8, Page 4823-4843, August 2026.
ABSTRACT Theacrine (1,3,7,9‐tetramethyluric acid) is a purine alkaloid detected in multiple wild and specialised tea germplasms (Camellia sinensis) from South China, including Kucha. However, the molecular mechanisms governing its biosynthesis remain poorly understood. Here, we identify CsTcS2 as a novel theacrine synthase in tea plant.
Ting Wu   +13 more
wiley   +1 more source

OsMYB306‐OsRAV11 Regulates Resistance of Rice to Striped Stem Borer by Modulating Serotonin Biosynthesis

open access: yesPlant Biotechnology Journal, Volume 24, Issue 8, Page 4951-4965, August 2026.
ABSTRACT Striped stem borer (SSB; Chilo suppressalis Walker) is one of the most destructive pests in rice production. Previous studies have demonstrated that SSB infestation induces transcription of OsT5H (tryptamine‐5‐hydroxylase) and biosynthesis of serotonin, a newly recognised phytohormone, and that disruption of serotonin biosynthesis ...
Jia‐Run Zhang   +9 more
wiley   +1 more source

PP2A regulates shade avoidance response by dephosphorylating phytochrome‐interacting factor 7 in Arabidopsis

open access: yesThe Plant Journal, Volume 127, Issue 3, August 2026.
Significance Statement The shade‐avoidance response allows plants to better access sunlight to compete against surrounding neighbors. In Arabidopsis, PIF7 can be dephosphorylated under shade and accumulates into the nucleus to promote auxin biosynthetic and signaling genes to promote stem elongation.
Xingbo Cai   +5 more
wiley   +1 more source

A Review On 1,2,4-Triazoles

open access: yes, 2012
ABSTRACT Triazole is a five membered heterocyclic system consisting of two carbon atoms and three nitrogen atoms shows wide range of biological activities. Triazoles can be synthesized using Einhorn-Brunner reaction or the Pellizzari reaction from acyl hydrazides and various different method.
openaire   +2 more sources

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