Results 41 to 50 of about 185 (123)

Anti-Inflammatory Activity of 1,2-Benzothiazine 1,1-Dioxide Derivatives

Pharmaceuticals
There is an urgent need to develop new anti-inflammatory compounds due to the versatility of their applications and the side effects associated with currently used nonsteroidal anti-inflammatory drugs (NSAIDs). Compounds containing the 1,2-benzothiazine 1,1-dioxide moiety in their structure have demonstrated a broad range of pharmacological activities,
Berenika M. Szczęśniak-Sięga, Izabela Topolska   +1 more
openaire   +1 more source

Medicinal Chemistry Updates on Bacterial Efflux Pump Modulators [PDF]

, 2018
Antibiotic resistance is one of the most pressing health issues of our days. It can arise due to a multiplicity of factors, such as target modification, decrease in the drug uptake, changes in the metabolic pathways and activation of efflux pumps.
Durães F., Pinto M., Sousa E.
core   +1 more source

Development and optimization of a methimazole microemulsion for topical application: Formulation characteristics and transdermal permeation

Journal of Cosmetic Dermatology, Volume 23, Issue 12, Page 4315-4324, December 2024.
Abstract Background Methimazole, an oral antithyroid drug, has recently gained attention for its skin‐brightening effects when applied topically to treat melasma. This study aims to develop, optimize, and characterize a methimazole microemulsion as a novel, safe approach for local melasma treatment.
Anayatollah Salimi, Hadis Hoseinzadeh, Saeed Mohammad Soleymani   +2 more
wiley   +1 more source

2‐Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity

Pigment Cell &Melanoma Research, Volume 37, Issue 4, Page 462-479, July 2024.
Schematic representation of 2‐MNG mode of action on melanin synthesis. Abstract Research on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side ...
Peggy Sextius, Emilie Warrick, Amélie Prévot‐Guéguiniat, Guillaume Lereaux, Florence Boirre, Ludwig Baux, Safa Ben Hassine, Jie Qiu, Xiaoming Huang, Jinzhu Xu, Sébastien Grégoire, Shosuke Ito, Kazumasa Wakamatsu, Xavier Marat   +13 more
wiley   +1 more source

Réactivité cupro-catalysée des systèmes mono, di et triiodés porteurs d'une fonction acide carboxylique ou dérivée (applications à la synthèse de nouveaux hétérocycles.) [PDF]

, 2011
Les hétérocycles oxygénés, azotés et soufrés sont des motifs présents dans de nombreux produits naturels possédant des activités biologiques intéressantes. Plusieurs publications décrivant la synthèse de ces hétérocycles en particulier oxygénés et azotés
ABARBRI, Mohamed, BAHLAOUAN, Zineb
core  

Synthesis, Characterization, Insilico Studies, and Biological Evaluation of Novel Hybrid Chalcone Derivatives as Antibacterial Agents [PDF]

, 2021
All the designed compounds were subjected to molecular docking studies for structural and interaction information. Ciprofloxacin and all designed compound 3a-t were docked in the active site of DNA gyrase subunit B and Binding affinities was calculated ...
Subhashini, A
core  

Rhodium-catalyzed C–H activation/cyclization of aryl sulfoximines with iodonium ylides towards polycyclic 1,2-benzothiazines

, 2021
The synthesis of polycyclic 1,2-benzothiazines through rhodium-catalyzed C–H activation/cyclization of S-aryl sulfoximines with iodonium ylides has been developed for the first time.
Changduo Pan, Gao Huang, Jin-Tao Yu, Yujia Shan   +3 more
core   +1 more source

Design of Phytic Acid Crosslinked Xerogels as Organic Photocatalysts for Visible Light‐Assisted Degradation of Dyes

Advanced Materials Interfaces, Volume 11, Issue 18, June 26, 2024.
Degradation of dyes using phytic acid crosslinked conducting polymer xerogels. The xerogels can be effectively applied for water remediation. Abstract Extensive research is being carried out on the degradation of water pollutants using various strategies to overcome the global water crisis.
Aleena Mir, Elham S. Aazam, Ufana Riaz
wiley   +1 more source

Synthesis, Reactivity and Application of Vinyl Sulfoximines and Vinyl Aminosulfoxonium Salts

European Journal of Organic Chemistry, Volume 27, Issue 8, February 26, 2024.
In this review, the multifaceted chemistry of vinyl sulfoximines and vinyl aminosulfoxonium salts is discussed. Emphasis is placed on the application in asymmetric synthesis. The discussion focuses on functionalized vinyl sulfoximines and vinyl aminosulfoxonium salts, as well as transformations that exploit the nucleofugacity of the sulfonimidoyl and ...
Hans‐Joachim Gais
wiley   +1 more source

Rhodium-Catalyzed Annulative Coupling Using Vinylene Carbonate as an Oxidizing Acetylene Surrogate [PDF]

Transition-metal-catalyzed C–H activation and subsequent oxidative cyclization with alkynes has been a pow-erful tool for the synthesis of polycyclic aromatic compounds.
Ghosh, Koushik, Miura, Masahiro, Nishii, Yuji   +2 more
core   +1 more source