Methyl 2-methyl-4-(oxiran-2-ylmethoxy)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
Acta Crystallographica Section E, 2010 In the title compound, C14H15NO6S, the thiazine ring adopts a distorted half-chair conformation. The structure displays several cooperative weak intermolecular C—H...O hydrogen-bonding interactions, giving rise to a two-dimensional sheet ...
Matloob Ahmad +4 more
doaj +1 more source
4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) and its Cu(II) Complex as New Oxicam Selective Cyclooxygenase-2 Inhibitors [PDF]
, 2012 4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) as nonsteroidal antiinflammatory drug (NSAIDs) of oxicam family has been synthesized bearing high se-lectivity for cyclooxygenase-2 (COX-2) inhibition and high ...
Ahmed Abdel-Hamid El-Asmy +2 more
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Thiazole Moiety: An Interesting Scaffold for Developing New Antitumoral Compounds [PDF]
, 2019 Currently, cancer is one of the major health problems of the human population and prominent cause of death. Thiazole ring has demonstrated many pharmacological activities including anticancer.
Aydillo, Carlos +3 more
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Synthesis of Sulfur Heterocycles by Palladium‐Catalyzed Cyclization
European Journal of Organic Chemistry, Volume 29, Issue 14, 15 April 2026.In spite of the well‐known palladium thiophilicity, sulfur‐containing acyclic substrates may efficiently undergo several different kinds of palladium‐catalyzed cyclization processes leading to highly important sulfur heterocycles in one synthetic step. Advances in this challenging and stimulating field of research are presented in this review.
Bartolo Gabriele
wiley +1 more source
N-(2,3-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
Acta Crystallographica Section E, 2009 In the crystal structure of the title compound, C18H18N2O4S, the thiazine ring adopts a distorted half-chair conformation. 1,2-Benzothiazines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of ...
doaj +1 more source
Hydrophobic interaction of 2-trifluoromethyl-N 10-substituted phenoxazines with bovine serum albumin and reversal of drug resistance in bacterial cells [PDF]
, 2015 Objective: The objective of this study was to report the hydrophobic interaction of 2-trifluoromethyl-N10 Methods: Binding of six compounds, 10-3-substituted phenoxazines with bovine serum albumin and reversal of drug resistance in bacterial cells.
Eregowda, G.B. +5 more
core
Modulation of Bacterial Multidrug Resistance Efflux Pumps of the Major Facilitator Superfamily [PDF]
, 2013 Bacterial infections pose a serious public health concern, especially when an infectious disease has a multidrug resistant causative agent. Such multidrug resistant bacteria can compromise the clinical utility of major chemotherapeutic antimicrobial ...
Manuel F. Varela +2 more
core +2 more sources
Advanced Science, Volume 12, Issue 40, October 27, 2025.This research showcases a micro‐dispensing strategy for integrating high‐performance organic electrochemical transistors (OECTs) and amplifiers onto flexible substrates. The method achieves precise material deposition, enabling fully micro‐dispensed OECT amplifiers with a record 1 MHz gain‐bandwidth product.
Roberto Granelli +4 more
wiley +1 more source
Cp*M-Catalyzed Direct Annulation with Terminal Alkynes and Their Surrogates for the Construction of Multi-Ring Systems [PDF]
Transition-metal-catalyzed C–H activation followed by oxidative cyclization with unsaturated coupling partners has been a valuable synthetic tool for the multi-ring molecular scaffolds.
Miura, Masahiro, Nishii, Yuji
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Journal of Heterocyclic Chemistry, Volume 62, Issue 9, Page 938-943, September 2025.Through an efficient solid‐phase synthesis method, 32 different 1,3,5,6‐tetra‐substituted 3,5‐dihydroimidazo[4,5‐c][1,2]thiazin‐4(1H)‐one 2,2‐dioxide derivatives were synthesized. The derivative library, with a total of four diversities, showed an overall yield of 7%–32% over 8 steps.
Jimin Moon +3 more
wiley +1 more source