Results 21 to 30 of about 202 (136)

A promising PET tracer candidate targeting α‐synuclein inclusions

, 2023
Clinical and Translational Medicine, Volume 13, Issue 9, September 2023.
Jie Xiang, Zhentao Zhang, Keqiang Ye
wiley   +1 more source

Anti-Inflammatory Properties of Novel 1,2-Benzothiazine Derivatives and Their Interaction with Phospholipid Model Membranes. [PDF]

Membranes (Basel)
The design of novel anti-inflammatory drugs remains a critical area of research in the development of effective treatments for inflammatory diseases. In this study, a series of 1,2-benzothiazine was evaluated through a multifaceted approach. In particular, we investigated the potential interactions of the potential drugs with lipid bilayers, an ...
Szczęśniak-Sięga BM, Maniewska J, Wiatrak B, Janek T, Nowotarska P, Czyżnikowska Ż.   +5 more
europepmc   +5 more sources

Synthesis of Sulfur Heterocycles by Palladium‐Catalyzed Cyclization

European Journal of Organic Chemistry, Volume 29, Issue 14, 15 April 2026.
In spite of the well‐known palladium thiophilicity, sulfur‐containing acyclic substrates may efficiently undergo several different kinds of palladium‐catalyzed cyclization processes leading to highly important sulfur heterocycles in one synthetic step. Advances in this challenging and stimulating field of research are presented in this review.
Bartolo Gabriele
wiley   +1 more source

2‐Phenyl‐1,2,6,7‐Tetrahydrocyclopenta[D][1,3]Thiazine‐4(5H)‐Thione: Synthesis, Crystal Structure, Hirshfeld Surface Analysis, DFT Calculations, ADMET Prediction, and Molecular Docking†

Journal of Chemistry, Volume 2026, Issue 1, 2026.
The compound 2‐phenyl‐1,2,6,7‐tetrahydrocyclopenta[d][1,3]thiazine‐4(5H)‐thione (I) was synthesized from benzylideneaniline and 2‐amino‐1‐cyclopentene‐dithiocarboxylic acid. Its molecular structure was confirmed by FT‐IR and NMR spectroscopy, and the crystalline phase was verified by powder X‐ray diffraction.
Gerzon E. Delgado, Jonathan Cisterna, Carla Coy, Asiloé J. Mora, Marilia Guillen, Edward Ávila, Ricardo R. Contreras, Cecilia Chacón, Gustavo Marroquin, Gerson Márquez, Munmun Bardhan   +10 more
wiley   +1 more source

Organic Electrochemical Transistors Monolithically Integrated with Precise Micro‐Dispensing Enable High‐Performance Biosignals Amplification

Advanced Science, Volume 12, Issue 40, October 27, 2025.
This research showcases a micro‐dispensing strategy for integrating high‐performance organic electrochemical transistors (OECTs) and amplifiers onto flexible substrates. The method achieves precise material deposition, enabling fully micro‐dispensed OECT amplifiers with a record 1 MHz gain‐bandwidth product.
Roberto Granelli, Virginia M. Demartis, Giulia Frusconi, Zsolt M. Kovács‐Vajna, Fabrizio Torricelli   +4 more
wiley   +1 more source

Solid‐Phase Synthesis of 1,3,5,6‐Tetra‐Substituted 3,5‐Dihydroimidazo[4,5‐c][1,2]Thiazin‐4(1 H)‐One 2,2‐Dioxide Derivatives

Journal of Heterocyclic Chemistry, Volume 62, Issue 9, Page 938-943, September 2025.
Through an efficient solid‐phase synthesis method, 32 different 1,3,5,6‐tetra‐substituted 3,5‐dihydroimidazo[4,5‐c][1,2]thiazin‐4(1H)‐one 2,2‐dioxide derivatives were synthesized. The derivative library, with a total of four diversities, showed an overall yield of 7%–32% over 8 steps.
Jimin Moon, Hyojin Lee, Sohee Kim, Taeho Lee   +3 more
wiley   +1 more source

NorA Efflux Pump Inhibitors: Expanding SAR Knowledge of Pyrazolo[4,3‐c][1,2]benzothiazine 5,5‐Dioxide Derivatives

Archiv der Pharmazie, Volume 358, Issue 5, May 2025.
The pyrazolo[4,3‐c][1,2]benzothiazine 5,5‐dioxide class was investigated with the aim of enlarging the array of Staphylococcus aureus NorA efflux pump inhibitors. The ethidium bromide efflux assay was used as a first indication of NorA inhibition; then, the ability of compounds to synergize with ciprofloxacin (CPX) against both wild‐type and resistant ...
Giada Cernicchi, Alessandra Di Gregorio, Tommaso Felicetti, Elisa Rampacci, Giulia Casari, Tatiana Armeni, Brenda Romaldi, Ermelinda Zefaj, Fabrizio Passamonti, Serena Massari, Giuseppe Manfroni, Maria Letizia Barreca, Oriana Tabarrini, Carla Vignaroli, Stefano Sabatini   +14 more
wiley   +1 more source

Development and optimization of a methimazole microemulsion for topical application: Formulation characteristics and transdermal permeation

Journal of Cosmetic Dermatology, Volume 23, Issue 12, Page 4315-4324, December 2024.
Abstract Background Methimazole, an oral antithyroid drug, has recently gained attention for its skin‐brightening effects when applied topically to treat melasma. This study aims to develop, optimize, and characterize a methimazole microemulsion as a novel, safe approach for local melasma treatment.
Anayatollah Salimi, Hadis Hoseinzadeh, Saeed Mohammad Soleymani   +2 more
wiley   +1 more source

2‐Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity

Pigment Cell &Melanoma Research, Volume 37, Issue 4, Page 462-479, July 2024.
Schematic representation of 2‐MNG mode of action on melanin synthesis. Abstract Research on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side ...
Peggy Sextius, Emilie Warrick, Amélie Prévot‐Guéguiniat, Guillaume Lereaux, Florence Boirre, Ludwig Baux, Safa Ben Hassine, Jie Qiu, Xiaoming Huang, Jinzhu Xu, Sébastien Grégoire, Shosuke Ito, Kazumasa Wakamatsu, Xavier Marat   +13 more
wiley   +1 more source

Design of Phytic Acid Crosslinked Xerogels as Organic Photocatalysts for Visible Light‐Assisted Degradation of Dyes

Advanced Materials Interfaces, Volume 11, Issue 18, June 26, 2024.
Degradation of dyes using phytic acid crosslinked conducting polymer xerogels. The xerogels can be effectively applied for water remediation. Abstract Extensive research is being carried out on the degradation of water pollutants using various strategies to overcome the global water crisis.
Aleena Mir, Elham S. Aazam, Ufana Riaz
wiley   +1 more source