Sulfoximine Assisted C–H Activation and Annulation via Vinylene Transfer: Access to Unsubstituted Benzothiazines [PDF]
Molecules, 2023 In this study, we report the synthesis of unsubstituted 1,2-benzothiazines through a redox-neutral Rh(III)-catalyzed C–H activation and [4+2]-annulation of S–aryl sulfoximines with vinylene carbonate.
Koneti Kondalarao +2 more
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Sulfoximines-Assisted Rh(III)-Catalyzed C–H Activation and Intramolecular Annulation for the Synthesis of Fused Isochromeno-1,2-Benzothiazines Scaffolds under Room Temperature [PDF]
Molecules, 2020 A mild and facile Cp*Rh(III)-catalyzed C–H activation and intramolecular cascade annulation protocol has been proposed for the furnishing of highly fused isochromeno-1,2-benzothiazines scaffolds using S-phenylsulfoximides and 4-diazoisochroman-3-imine as
Bao Wang +4 more
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Synthesis and α-Glucosidase Inhibition Activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl]-N-arylacetamides: An In Silico and Biochemical Approach [PDF]
Molecules, 2021 Diabetes mellitus (DM) is a chronic disorder and has affected a large number of people worldwide. Insufficient insulin production causes an increase in blood glucose level that results in DM.
Furqan Ahmad Saddique +9 more
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Evaluation of 1,2-Benzothiazine 1,1-Dioxide Derivatives In Vitro Activity towards Clinical-Relevant Microorganisms and Fibroblasts [PDF]
Molecules, 2020 The global concern related with growing number of bacterial pathogens, resistant to numerous antibiotics, prone scientific environment to search for new antimicrobials.
Ruth K. Dudek-Wicher +5 more
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Synthesis and Antimicrobial Activity of 1,2-Benzothiazine Derivatives [PDF]
Molecules, 2016 A number of 1,2-benzothiazines have been synthesized in a three-step process. Nine chalcones 1–9 bearing methyl, fluoro, chloro and bromo substituents were chlorosulfonated with chlorosulfonic acid to generate the chalcone sulfonyl chlorides 10–18. These
Chandani Patel +6 more
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N-(3,4-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
Acta Crystallographica Section E, 2009 1,2-Benzothiazines similar to the title compound, C18H18N2O4S, are well known in the literature for their biological activities and are used as medicines in the treatment of inflammation and rheumatoid arthritis. The thiazine ring adopts a distorted half-
Waseeq Ahmad Siddiqui +4 more
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Methyl 4-ethoxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
Acta Crystallographica Section E, 2008 In the crystal structure of the title compound, C13H15NO5S, the molecules exhibit weak S=O...H—C and C=O...H—C intermolecular interactions and arrange themselves into centrosymmetric dimers by means of π–π interactions (ring ...
Muhammad Zia-ur-Rehman +4 more
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Methyl 2-methyl-4-(oxiran-2-ylmethoxy)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
Acta Crystallographica Section E, 2010 In the title compound, C14H15NO6S, the thiazine ring adopts a distorted half-chair conformation. The structure displays several cooperative weak intermolecular C—H...O hydrogen-bonding interactions, giving rise to a two-dimensional sheet ...
Matloob Ahmad +4 more
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Green Synthesis and CatalysisTaking advantage of facilely available α-chloroketones as C(sp3)-based electrophilic partners and oxidized alkyne equivalents, we here present a novel CpxRh(III)-catalyzed enantioselective C–H [4 + 2] annulation of sulfoximines under mild and redox ...
Qingwei Song +6 more
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N-(2,3-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
Acta Crystallographica Section E, 2009 In the crystal structure of the title compound, C18H18N2O4S, the thiazine ring adopts a distorted half-chair conformation. 1,2-Benzothiazines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of ...
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