Results 71 to 80 of about 185 (123)

New 1,2-benzothiazine derivatives as inhibitors of cyclooxygenase with membrane perturbing potency

Current Topics in Biophysics
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Regioselective Syntheses of 1,2‐Benzothiazines by Rhodium‐Catalyzed Annulation Reactions

Angewandte Chemie - International Edition, 2015
AbstractRhodium‐catalyzed directed carbene insertions into aromatic CH bonds of S‐aryl sulfoximines lead to intermediates, which upon dehydration provide 1,2‐benzothiazines in excellent yields. The domino‐type process is regioselective and shows a high functional‐group tolerance. It is scalable, and the only by‐products are dinitrogen and water. Three
Carsten Bolm
exaly   +3 more sources

1,2‐Benzothiazines VIII. A novel semmler‐wolff type transformation of 2‐methyl‐2H‐1,2‐benzothiazin‐4‐one 1,1‐dioxide oxime

Journal of Heterocyclic Chemistry, 1977
AbstractRefluxing the oxime (1) of 2‐methyl‐2H‐1,2‐benzothiazin‐4(3H)one 1,1‐dioxide with tri‐fluoroacetic acid or with boron trifluoride in acetic acid gives the corresponding N‐acyl derivative (2 or 3) of 4‐amino‐2‐methyl‐2H‐1,2‐benzothiazin‐3(4H)one 1,1‐dioxide.
Harold Zinnes, Roger A. Comes, John Shavel   +2 more
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ChemInform Abstract: 1,2‐BENZOTHIAZINE 6. MITT. 3‐CARBAMOYL‐4‐HYDROXY‐2H‐1,2‐BENZOTHIAZIN‐1,1‐DIOXIDE ALS VERBINDUNGEN MIT ENTZUENDUNGSHEMMENDER WIRKUNG

Chemischer Informationsdienst, 1973
AbstractAus den 1,2‐Benzothiazinonen (I) erhält man durch Behandlung mit NaH und den Isocyanaten (II) die Carbamoylderivate (III), die auch aus den Estern (V) mit den Aminen (IV) erhalten werden können.
H. ZINNES, N. A. LINDO, J. C. SIRCAR, M. L. SCHWARTZ, J. SHAVEL, G. DIPASQUALE   +5 more
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Recent Advances in Synthesis and Medicinal Evaluation of 1,2‐Benzothiazine Analogues

Asian Journal of Organic Chemistry, 2022
AbstractBenzothiazines are one of the significant nitrogen containing heterocyclic scaffolds which are found to be multipurpose in the fields of drug discovery and medicinal chemistry. They are realized to be effective in curing enzymatic diseases caused by COX‐2, ALR‐2 (Aldose reductase enzyme), ALP (Alkaline phosphatase), 11β‐HSD 1 (11β ...
Reetu Reetu, Raghuram Gujjarappa, Chandi C. Malakar   +2 more
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Multilevel topological description of molecular packings in 1,2-benzothiazines

CrystEngComm, 2014
A new method for description of molecular networks and packings is proposed and implemented into the program package TOPOS.
Farhana Aman, Abdullah M. Asiri, Waseeq A. Siddiqui, Muhammad Nadeem Arshad, Adnan Ashraf, Nikita S. Zakharov, Vladislav A. Blatov   +6 more
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The synthesis of substituted 2H-1,2-benzothiazines 1,1-dioxides

Collection of Czechoslovak Chemical Communications, 1986
The base-catalyzed rearrangement of the esters of 2H-1,2-benzothiazolin-3-one-2-acetate 1,1-dioxide (IIa - IIc) afforded substituted 2H-1,2-benzothiazine-3-carboxylate 1,1-dioxides IIIa -IIIc. After N-alkylation and aminolysis the antiinflammatory drugs piroxicam and isoxicam were obtained.
Jiří Svoboda, Jaroslav Paleček, Václav Dědek   +2 more
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Synthesis and analgesic and anti-inflammatory activities of 1,2-benzothiazine derivatives

Archives of Pharmacal Research, 1999
Three 1,2-benzothiazine derivatives were synthesized, and their analgesic/anti-inflammatory efficacy and their effects on gastric irritation were evaluated. Among the three compounds, 39 exhibited the most potent analgesic action, but the effect was weaker than that of piroxicam.
E B, Lee, S K, Kwon, S G, Kim
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1,2‐Benzothiazine 1,1‐Dioxide α‐Ketoamide Analogues as Potent Calpain I Inhibitors.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ron, Bihovsky, Ming, Tao, John P, Mallamo, Gregory J, Wells   +3 more
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New β-aminovinylketonates with annealated 1,2-benzothiazine-1,1-dioxide fragment

Polyhedron, 2004
Abstract New β-aminovinylketones with heterocyclic 1,2-benzothiazine-1,1-dioxide and antipyrine moieties (LH) and their 3d-metal (Co II , Ni II , Cu II , Zn II ) chelates have been synthesized. Two types of chelates can be obtained based on the coordination of the LH ligand, depending when an available carbonyl (CO) group of the antipyrine fragment ...
A.D Garnovskii, Boris I Kharisov, E.L Anpilova, A.V Bicherov, O.Yu Korshunov, A.S Burlov, Miguel A Méndez-Rojas, L.M Blanco, G.S Borodkin, I.E Uflyand, U Ortiz Méndez   +10 more
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