Results 91 to 100 of about 202 (136)

Construction of 1,2‐Benzothiazine‐S,S‐Dioxide Heterocyclic Derivatives

ChemistrySelect
Abstract We investigated two synthetic methods for 1,2‐benzothiazine‐S,S‐dioxide heterocyclic derivatives. The first method involves cyclization via Suzuki–Miyaura coupling, while the second achieves cyclization through intramolecular C─H activation.
Mengjiao Liu, Yunge Yuan, Jiankang Yue, Fangzhi Huang, Wei Zhang, Changqing Wei   +5 more
openaire   +1 more source

1,2‐Benzothiazine 1,1‐Dioxide α‐Ketoamide Analogues as Potent Calpain I Inhibitors.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ron, Bihovsky, Ming, Tao, John P, Mallamo, Gregory J, Wells   +3 more
openaire   +2 more sources

New approach to the synthesis of 3-amino-1,2-benzothiazine 1,1-dioxides

Chemistry of Heterocyclic Compounds, 1992
The possibility of obtaining 3-amino-1,2-benzothiazine 1,1-dioxides by nucleophilic substitution of the chlorine atom in 5-nitro-2-chlorobenzenesulfonamides by carbanions generated from substituted acetonitriles was studied.
A. G. Nemazanyi, Yu. M. Volovenko, V. V. Neshchadimenko, F. S. Babichev   +3 more
openaire   +1 more source

Some new 1,2-benzothiazine derivatives with analgesic and anti-inflammatory activities.

Arzneimittel-Forschung, 1997
Twenty-three new 7-halo-4-hydroxy-2H(or alkyl)-N-(3-aralkyl-2-thio- 1-hydantoinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives were synthesized through the condensation of 7-halo-4-hydroxy-2H(or alkyl)-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxides with 1-amino-2-thio-3-aralkyl-imidazolidine-4-one.
S K, Kwon, M S, Park
openaire   +2 more sources

METAL CHELATES OF NEW LIGANDS: 1,2-BENZOTHIAZINE-1,1-DIOXIDE DERIVATIVES

Journal of Coordination Chemistry, 2001
Abstract The novel chelates ML2 (M = Co, Ni, Cu, Zn) were obtained by the interaction of 3-benzoyl-4-hydroxy-1,2-benzothiazine-4(3H)-on-1,1-dioxide and 2-methyl-3-benzoyl-4-hydroxy-1,2-benzo-thiazine-4(3H)-on-1,1-dioxide with elemental metals (direct electrochemical synthesis) or their acetates (chemical synthesis) in methanol.
A. V. Bicherov, B. I. Kharisov, L. M. Blanco, O. Yu. Korshunov, E. L. Koroleva, A. S. Burlov, G. S. Borodkin, V. P. Kurbatov, I. E. Uflyand, A. D. Garnovskii   +9 more
openaire   +1 more source

1,2-Benzothiazine derivatives: antibacterial and antifungal activity with structure–activity relationship insights

Bioorganic Chemistry
The rise of multidrug-resistant bacteria presents a major global health challenge, driving the search for novel antibacterial agents. 1,2-Benzothiazine derivatives have emerged as versatile scaffolds with potential to overcome bacterial resistance.
Berenika M, Szczęśniak-Sięga, Izabela, Topolska   +1 more
openaire   +2 more sources

1,2-Benzothiazine 1,1-dioxide carboxylate derivatives as novel potent inhibitors of aldose reductase

Bioorganic & Medicinal Chemistry, 2011
Due to the importance of aldose reductase (ALR2) as a potential drug target in the treatment of diabetic complications, there are increasing interests in design and synthesis of ALR2 inhibitors. Here, we prepared 1,2-benzothiazine 1,1-dioxide acetic acid derivatives and investigated their inhibition activity.
Xin, Chen, Shuzhen, Zhang, Yanchun, Yang, Saghir, Hussain, Minlan, He, Dequan, Gui, Bing, Ma, Chaojun, Jing, Zhixin, Qiao, Changjin, Zhu, Qun, Yu   +10 more
openaire   +2 more sources

ChemInform Abstract: 1,2‐BENZOTHIAZINE 7. MITT. BORTRIFLUORID‐KATALYSIERTE UMLAGERUNG DES EPOXIDES AUS 3‐BENZYLIDEN‐2‐METHYL‐2H‐1,2‐BENZOTHIAZIN‐4(3H)ON‐1,1‐DIOXID

Chemischer Informationsdienst, 1973
AbstractAus den Epoxiden (I) erhält man mit Bortrifluorid die Einschiebungsprodukte (II).
H. ZINNES, J. SHAVEL
openaire   +1 more source

Synthesis and antiinflammatory/analgesic activities of N-heterocyclic carboxamides of thiopyrano-1,2-benzothiazine.

Farmaco (Societa chimica italiana : 1989), 1989
We report the synthesis of N-heterocyclic carboxamides of 5-methyl-4-oxo-2,3,4,5-tetrahydrothiopyrano [3,2-c][1,2]benzothiazine 6,6-dioxide, their antiinflammatory and analgesic activities and the attempts to obtain a corresponding sulfoxidate series.
SCHIAFFELLA, Fausto, FRINGUELLI, Renata, CECCHETTI, Violetta, FRAVOLINI, Arnaldo, G. Bruni, F. M. Runci   +5 more
openaire   +2 more sources

1,2-Benzothiazines. 6. 3-Carbamoyl-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxides as antiinflammatory agents

Journal of Medicinal Chemistry, 1973
H, Zinnes, N A, Lindo, J C, Sircar, M L, Schwartz, J, Shavel, G, DiPasquale   +5 more
openaire   +2 more sources