Results 81 to 90 of about 185 (123)

Novel Synthesis of a 2H-1,2-Benzothiazine -1,1-Dioxide Derivative

Synthetic Communications, 2000
Abstract We report a novel synthesis of 4-chloro-2-cyclohexyl-6,7-dimethoxy-2H-1,2-benzothiazine-1,1-dioxide 6 from 3,4-dimethoxychalcone 1. Chlorosulfonation of 1 followed by amination, then epoxidation under basic conditions with immediate elimination of the benzoyl group and electrophilic chlorination resulted in 6. A mechanism is suggested.
Jatinder P. Bassin, Martin J. Frearson, Karim Al-Nawwar   +2 more
openaire   +1 more source

Synthesis of 1,2-Benzothiazine via Nickel-Catalyzed Electrochemical Intramolecular Amination

Organic Letters
Constructing a C-N bond by merging electrochemistry and nickel catalysis is considered a powerful strategy. Herein, we investigate highly efficient intramolecular amination at room temperature with excellent functional group tolerance. Mechanistic studies suggest that the rapid ligand exchange may lead to the NiI/NiIII catalytic cycle.
Zhao-Ran Liu, Simon Herbert, Hartmut Schirok, Cong Ma, Tian-Sheng Mei   +4 more
openaire   +2 more sources

METAL CHELATES OF NEW LIGANDS: 1,2-BENZOTHIAZINE-1,1-DIOXIDE DERIVATIVES

Journal of Coordination Chemistry, 2001
Abstract The novel chelates ML2 (M = Co, Ni, Cu, Zn) were obtained by the interaction of 3-benzoyl-4-hydroxy-1,2-benzothiazine-4(3H)-on-1,1-dioxide and 2-methyl-3-benzoyl-4-hydroxy-1,2-benzo-thiazine-4(3H)-on-1,1-dioxide with elemental metals (direct electrochemical synthesis) or their acetates (chemical synthesis) in methanol.
A. V. Bicherov, B. I. Kharisov, L. M. Blanco, O. Yu. Korshunov, E. L. Koroleva, A. S. Burlov, G. S. Borodkin, V. P. Kurbatov, I. E. Uflyand, A. D. Garnovskii   +9 more
openaire   +1 more source

ChemInform Abstract: 1,2‐BENZOTHIAZINE 7. MITT. BORTRIFLUORID‐KATALYSIERTE UMLAGERUNG DES EPOXIDES AUS 3‐BENZYLIDEN‐2‐METHYL‐2H‐1,2‐BENZOTHIAZIN‐4(3H)ON‐1,1‐DIOXID

Chemischer Informationsdienst, 1973
AbstractAus den Epoxiden (I) erhält man mit Bortrifluorid die Einschiebungsprodukte (II).
H. ZINNES, J. SHAVEL
openaire   +1 more source

Construction of 1,2‐Benzothiazine‐S,S‐Dioxide Heterocyclic Derivatives

ChemistrySelect
Abstract We investigated two synthetic methods for 1,2‐benzothiazine‐S,S‐dioxide heterocyclic derivatives. The first method involves cyclization via Suzuki–Miyaura coupling, while the second achieves cyclization through intramolecular C─H activation.
Mengjiao Liu, Yunge Yuan, Jiankang Yue, Fangzhi Huang, Wei Zhang, Changqing Wei   +5 more
openaire   +1 more source

ChemInform Abstract: THE SYNTHESIS OF SOME NEW 1,2‐BENZOTHIAZINES

Chemischer Informationsdienst, 1981
AbstractDurch Alkylierung des Benzothiazinderivats (I) mit Alkyliodiden (II) entstehen die Alkylderivate des Esters (III), die mit Aminopyridin (IV) zu den Amiden (V) umgesetzt werden.
openaire   +1 more source

1,2-Benzothiazine 1,1-dioxide carboxylate derivatives as novel potent inhibitors of aldose reductase

Bioorganic & Medicinal Chemistry, 2011
Due to the importance of aldose reductase (ALR2) as a potential drug target in the treatment of diabetic complications, there are increasing interests in design and synthesis of ALR2 inhibitors. Here, we prepared 1,2-benzothiazine 1,1-dioxide acetic acid derivatives and investigated their inhibition activity.
Xin, Chen, Shuzhen, Zhang, Yanchun, Yang, Saghir, Hussain, Minlan, He, Dequan, Gui, Bing, Ma, Chaojun, Jing, Zhixin, Qiao, Changjin, Zhu, Qun, Yu   +10 more
openaire   +2 more sources

ChemInform Abstract: Novel Synthesis of 3‐Amino‐1,2‐benzothiazine 1,1‐Dioxides.

ChemInform, 1993
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. G. NEMAZANYI, YU. M. VOLOVENKO, V. V. NESHCHADIMENKO, F. S. BABICHEV   +3 more
openaire   +1 more source

ChemInform Abstract: Synthesis of 3,4‐Dihydro‐2H‐1,2‐benzothiazine 1,1‐Dioxides.

ChemInform, 1992
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
C. CAMOUTSIS, P. CATSOULACOS
openaire   +1 more source

Some new 1,2-benzothiazine derivatives with analgesic and anti-inflammatory activities.

Arzneimittel-Forschung, 1997
Twenty-three new 7-halo-4-hydroxy-2H(or alkyl)-N-(3-aralkyl-2-thio- 1-hydantoinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives were synthesized through the condensation of 7-halo-4-hydroxy-2H(or alkyl)-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxides with 1-amino-2-thio-3-aralkyl-imidazolidine-4-one.
S K, Kwon, M S, Park
openaire   +2 more sources