Results 71 to 80 of about 14,595,151 (227)

The Mechanism of 1,25-Dihydroxyvitamin D3Autoregulation in Keratinocytes [PDF]

Journal of Biological Chemistry, 2002
The synthesis of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) from its precursor, 25-dihydroxyvitamin D(3) (25(OH)D(3)), is catalyzed by the mitochondrial cytochrome P450 enzyme 25-hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase). It has been generally assumed that 1,25(OH)(2)D(3) inhibits the activity of this enzyme by regulating its ...
Zhongjian, Xie, Scott J, Munson, Ningwu, Huang, Anthony A, Portale, Walter L, Miller, Daniel D, Bikle   +5 more
openaire   +2 more sources

25-hydroxyvitamin D and 1,25-dihydroxyvitamin D at baseline, day 8, day 36, day 50 and change from baseline.

, 2016
25-hydroxyvitamin D and 1,25-dihydroxyvitamin D at baseline, day 8, day 36, day 50 and change from baseline.
Gerd-Rüdiger Burmester (11520), Jacqueline Detert (3150189), Pascal Klaus (3150177), Frank Buttgereit (305278), Vera Höhne-Zimmer (3150174), Leonora Franke (3150183), Ralf Uebelhack (3150171), Tanja Braun (91009), Malgorzata Hajdukiewicz (3150186), Helmut Piazena (3150180), Maria Gudrun Biersack (3150168)   +10 more
core   +1 more source

Early 1,25-dihydroxyvitamin D3-glycosides supplementation: an efficient feeding strategy against bacterial chondronecrosis with osteomyelitis lameness in broilers assessed by using an aerosol transmission model

Journal of Applied Poultry Research
SUMMARY: Bacterial chondronecrosis with osteomyelitis (BCO) lameness is a leg disorder in broilers leading to huge economic losses, food safety concerns, and animal welfare issues in the poultry industry.
Andi Asnayanti, Khawla Alharbi, Anh D.T. Do, Layla Al-Mitib, Kathrin Bühler, Jan Dirk Van der Klis, Javier Gonzalez, Michael T. Kidd, Adnan A.K. Alrubaye   +8 more
doaj   +1 more source

Idiopathic immune‐mediated polyarthritis in a dog associated with ionised hypercalcaemia and probable ischaemic dermatopathy

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 5‐year‐old, spayed, female Shiba Inu was presented with a 6‐week history of reduced appetite, lethargy and generalised stiffness, which showed only limited improvement despite anti‐inflammatory treatment. The most significant clinical abnormalities were pyrexia, stiffness, pain on joint manipulation and cutaneous lesions. Laboratory findings
Jeanne Bergeat, Eddy Nassif, Sarah Berger, Isabelle Lagrange, Noëlle Cochet‐Faivre, Pierre Deshuillers, Maxime Kurtz   +6 more
wiley   +1 more source

Serum 1,25-Dihydroxyvitamin D: An Outcome Prognosticator in Human Sepsis - Figure 4

, 2013
1,25-dihydroxyvitamin D (1,25(OH)2D) as a function of parathyroid hormone (PTH). The plot shows that in both groups, there is a parallel decrease in ln(1,25(OH)2D) for increases in ln(PTH).
H. Bryant Nguyen (586196), K. H. William Lau (586198), Blen Eshete (586197), David Baylink (586201), Mark Villarin (586200), Adarsh Sai (586199)   +5 more
core   +1 more source

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1‐Dependent Suppression of ROMK

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous knockout (KLhet) mice, characterized by reduced Klotho levels, were used ...
Wakako Kawarazaki, Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Takeshi Marumo, Toshiro Fujita   +6 more
wiley   +1 more source

Vitamin D: Physiology, Pharmacology and Clinical Evidence for Supplementation—A Narrative Review

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Vitamin D is a nutrient and prohormone obtained from diet and supplements and synthesized in the skin. It is essential for calcium and phosphate homeostasis and skeletal health and influences multiple extra‐skeletal processes, yet deficiency remains common worldwide.
Jyrki K. Virtanen
wiley   +1 more source

Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man. [PDF]

, 1984
Previous in vitro studies in rachitic rat liver suggested that 1,25-dihydroxyvitamin D inhibits the hepatic production of 25-hydroxyvitamin D (25-OHD). An investigation therefore was carried out in eight normal subjects to determine whether concomitant
S Shaw, Bell, Norman H., Turner, Russell T., N H Bell, R T Turner, Shaw, Sheryl   +5 more
core   +1 more source

A Case of Cosecretion of Parathyroid Hormone-Related Protein and 1,25-Dihydroxyvitamin D in Small Cell Lung Carcinoma Presenting as Symptomatic Hypercalcemia

Annals of Internal Medicine: Clinical Cases
A 75-year-old man presented with altered mental status in the setting of hypercalcemia. Computed tomography imaging showed a new right upper lobe lung lesion and extensive metastatic disease of the spine.
John Pueringer, Danich Qadir, James Love, Ryan Knodle, Michael Gianarakis, Gabriela Mendez, Frank Weinberg   +6 more
doaj   +1 more source

Exploratory Analysis of Type 2 Diabetes Mellitus Metabolic Phenotypes and Their Association With Vitamin D Status in Primary Care Patients

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10603-10614, November 2026.
ABSTRACT Aims This study aimed to perform an exploratory characterisation of metabolic phenotypes in primary care patients with type 2 diabetes mellitus (T2DM), using a predefined approach and examine their association with vitamin D status. Materials and Methods This cross‐sectional study included 178 participants randomly selected in Sergipe, Brazil.
Liliane Viana Pires, Matheus Menezes‐Santos, Andréa Costa Goes, Heitor Siqueira Ribeiro, Luana Ferreira Alves, Beatriz Cruz dos Santos, Jéssyca Teles Barreto, Roberta Cristina Vieira Meneses, Ana Mara de Oliveira e Silva, Ana Hermínia Andrade e Silva, Sadraque Eneas de Figueiredo Lucena   +10 more
wiley   +1 more source