Anti-Thymocyte Globulin Treatment Augments 1,25-Dihydroxyvitamin D3 Serum Levels in Patients Undergoing Hematopoietic Stem Cell Transplantation [PDF]
Frontiers in Immunology, 2022 Application of anti-thymocyte globulin (ATG) is a widely used strategy for the prevention of graft-versus-host disease (GvHD). As vitamin D3 serum levels are also discussed to affect hematopoietic stem cell transplantation (HSCT) outcome and GvHD ...
Carina Matos +19 more
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1,25-dihydroxyvitamin D3 ameliorates lupus nephritis through inhibiting the NF-κB and MAPK signalling pathways in MRL/lpr mice [PDF]
BMC Nephrology, 2022 Background Lupus nephritis (LN) is a common and serious complication of systemic lupus erythematosus (SLE). However, the aetiology and pathogenesis of LN remain unknown.
Xuewei Li +6 more
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1,25-Dihydroxyvitamin D3 modulates adipogenesis of human adipose-derived mesenchymal stem cells dose-dependently [PDF]
Nutrition & Metabolism, 2021 Purpose 1,25-dihydroxyvitamin D3 may regulate adipogenesis in adipocytes in-vitro, but little is known about possible molecular mechanisms related to the inhibitory effect of 1,25-dihydroxyvitamin D3 on adipogenesis in humans҆ adipose tissue. Methodology
Amin Salehpour +5 more
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1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage [PDF]
JCI Insight, 2023 Intact fibroblast growth factor 23 (iFGF23) is a phosphaturic hormone that is cleaved by furin into N-terminal and C-terminal fragments. Several studies have implicated vitamin D in regulating furin in infections. Thus, we investigated the effect of 1,25-
Han Xie +11 more
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Single-cell RNA sequencing identifies Fgf23-expressing osteocytes in response to 1,25-dihydroxyvitamin D3 treatment [PDF]
Frontiers in Physiology, 2023 Fibroblast growth factor 23 (FGF23), a hormone, mainly produced by osteocytes, regulates phosphate and vitamin D metabolism. By contrast, 1,25-dihydroxyvitamin D3, the active form of vitamin D, has been shown to enhance FGF23 production.
Ayako Hanai +8 more
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1,25-Dihydroxyvitamin D3 ameliorates neutrophilic asthma through modulation of ERS-NLRP3 inflammasome axis in a mouse model [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Asthma is a heterogeneous disease. Neutrophilic asthma is associated with severe asthma and poor response to inhaled corticosteroids. We investigated whether 1,25-dihydroxyvitamin D3 can ameliorate neutrophilic airway inflammation, inhibit ...
Jing-hong Zhang +3 more
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FGF23, alpha-Klotho and vitamin D mediated calcium-phosphate metabolism in haemodialysis patients [PDF]
Journal of Medical Biochemistry, 2021 Background: Klotho is a protein that acts as a co-receptor for FGF23. FGF23-Klotho axis has great importance regarding the regulation of mineral metabolism by kidneys.
Pasaoglu Ozge Tugce +4 more
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TRPV6 determines the effect of vitamin D3 on prostate cancer cell growth. [PDF]
PLoS ONE, 2011 Despite remarkable advances in the therapy and prevention of prostate cancer it is still the second cause of death from cancer in industrialized countries.
V'yacheslav Lehen'kyi +10 more
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JTO Clinical and Research Reports, 2021 Hypercalcemia is a common electrolyte abnormality in malignancy and is largely caused by activation of parathyroid hormone (PTH) pathways. We report the case of a 76-year-old man with hypercalcemia primarily owing to 1,25-dihydroxyvitamin D3 ...
Tomohito Saito, MD, PhD +12 more
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Vitamin D: A complementary nutritional therapy for treatment of glioblastoma?
Advances in Clinical Neuroscience & Rehabilitation, 2022 The active vitamin D hormone, 1,25-dihydroxyvitamin D3, is well established to inhibit cellular proliferation and induce differentiation in several cell types of the central nervous system.
Síle Griffin, Fiona Griffin
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